(Q37658863)

English

Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status.

scientific article published on January 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021291%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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Europe PubMed Central

Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021291%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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based on heuristic

inferred from title

lymphoblastic leukemia

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Gabriele Stocco

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021291%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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Kristine R Crews

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021291%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

William E Evans

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021291%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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1 January 2010

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15 January 2020

Expert Opinion on Drug Safety

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021291%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

9

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15 January 2020

1

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15 January 2020

23-37

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021291%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Treatment of acute lymphoblastic leukemia

1 reference

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21 January 2018

Acute lymphoblastic leukaemia

1 reference

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21 January 2018

Treating childhood acute lymphoblastic leukemia without cranial irradiation

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21 January 2018

Ancestry and pharmacogenetics of antileukemic drug toxicity

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21 January 2018

Unexpectedly severe toxicity from intensive early treatment of childhood lymphoblastic leukemia

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21 January 2018

Pharmacogenetics in acute lymphoblastic leukemia

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21 January 2018

Moving towards individualized medicine with pharmacogenomics

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21 January 2018

Pharmacogenomics of acute lymphoblastic leukemia

1 reference

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21 January 2018

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

1 reference

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21 January 2018

Pharmacogenomics--drug disposition, drug targets, and side effects

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21 January 2018

Pharmacogenetics of cancer therapy: getting personal

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21 January 2018

Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

1 reference

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21 January 2018

Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism

1 reference

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21 January 2018

Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease.

1 reference

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21 January 2018

Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing

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21 January 2018

The purine path to chemotherapy

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21 January 2018

Drug methylation in cancer therapy: lessons from the TPMT polymorphism

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21 January 2018

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

1 reference

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21 January 2018

Structure and dynamics of thioguanine-modified duplex DNA

1 reference

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21 January 2018

Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics.

1 reference

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21 January 2018

Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital

1 reference

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21 January 2018

Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1517%2F14740330903426151

21 January 2018

Thiopurine methyltransferase in acute lymphoblastic leukemia

1 reference

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21 January 2018

Should TPMT genotype and activity be used to monitor 6-mercaptopurine treatment in children with acute lymphoblastic leukaemia?

1 reference

https://api.crossref.org/works/10.1517%2F14740330903426151

21 January 2018

Analysis of thiopurine S-methyltransferase polymorphism in the population of Serbia and Montenegro and mercaptopurine therapy tolerance in childhood acute lymphoblastic leukemia.

1 reference

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21 January 2018

Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia

1 reference

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21 January 2018

Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

1 reference

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21 January 2018

High incidence of secondary brain tumours after radiotherapy and antimetabolites.

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21 January 2018

Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

1 reference

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21 January 2018

Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols.

1 reference

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21 January 2018

Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia

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21 January 2018

Transporter-mediated protection against thiopurine-induced hematopoietic toxicity

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21 January 2018

Role of MRP4 and MRP5 in biology and chemotherapy

1 reference

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21 January 2018

Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia

1 reference

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21 January 2018

Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment

1 reference

https://api.crossref.org/works/10.1517%2F14740330903426151

21 January 2018

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

1 reference

https://api.crossref.org/works/10.1517%2F14740330903426151

21 January 2018

Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study

1 reference

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21 January 2018

Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression

1 reference

https://api.crossref.org/works/10.1517%2F14740330903426151

21 January 2018

Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine

1 reference

https://api.crossref.org/works/10.1517%2F14740330903426151

21 January 2018

Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1517%2F14740330903426151

21 January 2018

Meta-analysis: Inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease.

1 reference

https://api.crossref.org/works/10.1517%2F14740330903426151

21 January 2018

The increasing complexity of mercaptopurine pharmacogenomics

1 reference

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21 January 2018

Pharmacogenetic significance of inosine triphosphatase

1 reference

https://api.crossref.org/works/10.1517%2F14740330903426151

21 January 2018

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

1 reference

https://api.crossref.org/works/10.1517%2F14740330903426151

21 January 2018

Characterization of the inosine triphosphatase (ITPA) gene: haplotype structure, haplotype-phenotype correlation and promoter function

1 reference

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21 January 2018

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency in the Japanese population

1 reference

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21 January 2018

Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.

1 reference

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21 January 2018

Functional study of the P32T ITPA variant associated with drug sensitivity in humans.

1 reference

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21 January 2018

Distribution of ITPA P32T alleles in multiple world populations

1 reference

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21 January 2018

Pro32Thr polymorphism of inosine triphosphate pyrophosphatase gene predicts efficacy of low-dose azathioprine for patients with systemic lupus erythematosus

1 reference

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21 January 2018

Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment

1 reference

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21 January 2018

"Low-risk" prediction rule for pediatric oncology patients presenting with fever and neutropenia

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21 January 2018

Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients

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21 January 2018

Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: a systematic review

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Admission clinical and laboratory factors associated with death in children with cancer during a febrile neutropenic episode

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21 January 2018

TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease

1 reference

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21 January 2018

Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

1 reference

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21 January 2018

Genomewide association studies and human disease

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21 January 2018

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Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia

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21 January 2018

A second generation human haplotype map of over 3.1 million SNPs

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Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism

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Azathioprine in paediatric inflammatory bowel disease: an Italian multicentre survey

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Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease

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21 January 2018

Identifiers

10.1517/14740330903426151

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021291%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20021291%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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