(Q37660623)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

title

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

James D Brenton

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Marco Di Antonio

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Steven McKinney

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Nigel J O'Neil

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Daniel Lai

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Darren N Saunders

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Grant W Brown

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Samuel Aparicio

39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

33

David Cescon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

author name string

Hong Xu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Veena Mathew

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Brandon Ho

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Nancy Dos Santos

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Jennifer Silvester

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Vivien Wei

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Jessica Garcia

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Farhia Kabeer

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Priscilla Soriano

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Judit Banáth

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Derek S Chiu

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Daniel D Le

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Frank B Ye

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Anni Zhang

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Kelsie Thu

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

John Soong

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Shu-Chuan Lin

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Angela Hsin Chin Tsai

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Tomo Osako

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Teresa Algara

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Jason Wong

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Jian Xian

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Marcel B Bally

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Sohrab P Shah

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Tak W Mak

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Peter C Stirling

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Phil Hieter

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Shankar Balasubramanian

38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Carlos Caldas

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

language of work or name

English

0 references

publication date

17 February 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

page(s)

14432

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

3 April 2020

copyright license

start time

17 February 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5321743/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms14432

0 references

cites work

CX-5461 induces autophagy and inhibits tumor growth via mammalian target of rapamycin-related signaling pathways in osteosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Pif1 family helicases suppress genome instability at G-quadruplex motifs

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Epigeneitc silencing of ribosomal RNA genes by Mybbp1a.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Mutability and mutational spectrum of chromosome transmission fidelity genes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Simultaneous inference in general parametric models

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Replication blocking lesions present a unique substrate for homologous recombination

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Prevalence of quadruplexes in the human genome

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Highly prevalent putative quadruplex sequence motifs in human DNA

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

53BP1 is required for class switch recombination

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

The comet assay for DNA damage and repair: principles, applications, and limitations

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Fluorescence resonance energy transfer as a probe for G-quartet formation by a telomeric repeat

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Determining mutation rates in bacterial populations

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Cancer risks in BRCA2 mutation carriers

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Identification of the breast cancer susceptibility gene BRCA2

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

G-quadruplex structures mark human regulatory chromatin

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Small-molecule-induced DNA damage identifies alternative DNA structures in human genes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

High-throughput sequencing of DNA G-quadruplex structures in the human genome

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

Nucleolar size indicates the rapidity of cell proliferation in cancer tissues

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321743

The comet assay: a method to measure DNA damage in individual cells

1 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS14432

7 January 2021

The development and use of a DNA polymerase arrest assay for the evaluation of parameters affecting intrastrand tetraplex formation

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS14432

7 January 2021

An evaluation of the double thymidine block for synchronizing mammalian cells at the G1-S border*1

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS14432

7 January 2021

A power study of a rank transform for the two-way classification model when interaction may be present

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS14432

7 January 2021

Fitting Linear Mixed-Effects Models Using lme4

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS14432

7 January 2021

Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28211448

12 December 2020

inferred from PubMed ID database lookup

BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28211448

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NCOMMS14432

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28211448%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

PubMed publication ID

28211448

1 reference