(Q37667917)

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SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells

scientific article published on 27 February 2017

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Europe PubMed Central

PMC publication ID

21 August 2017

SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (English)

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Europe PubMed Central

PMC publication ID

21 August 2017

mesenchymal stem cell

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Gerjo J. V. M. van Osch

6

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Gerjo J V M van Osch

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Europe PubMed Central

PMC publication ID

21 August 2017

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Laurie M G de Kroon

1

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Europe PubMed Central

PMC publication ID

21 August 2017

Roberto Narcisi

2

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Europe PubMed Central

PMC publication ID

21 August 2017

Guus G H van den Akker

3

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Europe PubMed Central

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21 August 2017

Elly L Vitters

4

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Europe PubMed Central

PMC publication ID

21 August 2017

Esmeralda N Blaney Davidson

5

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21 August 2017

Peter M van der Kraan

7

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21 August 2017

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27 February 2017

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21 August 2017

Scientific Reports

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21 August 2017

7

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Europe PubMed Central

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21 August 2017

43164

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Europe PubMed Central

PMC publication ID

21 August 2017

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Creative Commons Attribution 4.0 International

27 February 2017

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5327413/fullTextXML

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1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5327413/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Activin Receptor-Like Kinase Receptors ALK5 and ALK1 Are Both Required for TGFβ-Induced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Cartilage Repair With Autologous Bone Marrow Mesenchymal Stem Cell Transplantation: Review of Preclinical and Clinical Studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

An educational review of cartilage repair: precepts & practice--myths & misconceptions--progress & prospects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

SMAD4 mutations causing Myhre syndrome result in disorganization of extracellular matrix improved by losartan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

A restricted spectrum of mutations in the SMAD4 tumor-suppressor gene underlies Myhre syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Phospho-control of TGF-beta superfamily signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Smad3 activates the Sox9-dependent transcription on chromatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Smad transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

New insights into TGF-beta-Smad signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Hierarchical model of gene regulation by transforming growth factor beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Controlling TGF-beta signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

All for one and one for all: condensations and the initiation of skeletal development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Multilineage potential of adult human mesenchymal stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

23 August 2017

Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

6 September 2017

Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

6 September 2017

TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

14 September 2017

Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming growth factor-beta responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

14 September 2017

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

28 September 2017

Smad2 role in mesoderm formation, left-right patterning and craniofacial development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

28 September 2017

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

28 September 2017

BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

25 June 2018

Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

25 June 2018

Smad3 mutant mice develop metastatic colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

25 June 2018

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

25 June 2018

Proliferation as a requirement for in vitro chondrogenesis of human mesenchymal stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

1 September 2018

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

1 September 2018

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

1 September 2018

Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

1 September 2018

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

1 September 2018

Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

1 September 2018

Mutation analysis of the Smad3 gene in human osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

1 September 2018

Smad signaling in mesenchymal and chondroprogenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

1 September 2018

Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

1 September 2018

In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5327413

1 September 2018

All for one and one for all: condensations and the initiation of skeletal development

1 reference

https://api.crossref.org/works/10.1038%2FSREP43164

21 January 2018

Phenotypic spectrum of the SMAD3-related aneurysms–osteoarthritis syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSREP43164

21 January 2018

Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28240243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3

1 reference

https://pubmed.ncbi.nlm.nih.gov/28240243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28240243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smad4 is required for the normal organization of the cartilage growth plate

1 reference

https://pubmed.ncbi.nlm.nih.gov/28240243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smad signaling determines chondrogenic differentiation of bone-marrow-derived mesenchymal stem cells: inhibition of Smad1/5/8P prevents terminal differentiation and calcification

1 reference

https://pubmed.ncbi.nlm.nih.gov/28240243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28240243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of SMAD4 account for both LAPS and Myhre syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/28240243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow

1 reference

https://pubmed.ncbi.nlm.nih.gov/28240243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SREP43164

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

release_wrelsfntpndpxcxhubiw5pyvmu

1 reference

https://api.fatcat.wiki/v0/release/wrelsfntpndpxcxhubiw5pyvmu

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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