(Q37670159)

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Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice

scientific article published on 25 October 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

21 August 2017

Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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Julie Piccand

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Gérard Gradwohl

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Gérard Gradwohl

6

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Aline Meunier

2

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Europe PubMed Central

PMC publication ID

21 August 2017

Carole Merle

3

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Europe PubMed Central

PMC publication ID

21 August 2017

Zhengping Jia

4

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Europe PubMed Central

PMC publication ID

21 August 2017

Jean-Vianney Barnier

5

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Europe PubMed Central

PMC publication ID

21 August 2017

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publication date

25 October 2013

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Europe PubMed Central

PMC publication ID

21 August 2017

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Europe PubMed Central

PMC publication ID

21 August 2017

63

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Europe PubMed Central

PMC publication ID

21 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

203-215

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Europe PubMed Central

PMC publication ID

21 August 2017

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

28 August 2021

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April 2022 Public Data File from Crossref

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3968432/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Sox9-haploinsufficiency causes glucose intolerance in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Rfx6 directs islet formation and insulin production in mice and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Gut endocrine cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

A practical guide to rodent islet isolation and assessment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

PAK signalling in neuronal physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Regulation of pancreatic beta-cell mass

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Opposing actions of Arx and Pax4 in endocrine pancreas development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

p21-activated kinases: three more join the Pak.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

PAK3 mutation in nonsyndromic X-linked mental retardation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

23 August 2017

Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

6 September 2017

Pancreas organogenesis: from bud to plexus to gland

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

6 September 2017

XPak3 promotes cell cycle withdrawal during primary neurogenesis in Xenopus laevis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

14 September 2017

Extracellularly regulated kinases 1/2 (p44/42 mitogen-activated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

14 September 2017

Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

14 September 2017

NEUROG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

25 June 2018

A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

25 June 2018

Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

25 June 2018

A multipotent progenitor domain guides pancreatic organogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

1 September 2018

Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

1 September 2018

Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

1 September 2018

Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3968432

1 September 2018

The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/24163148

12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.2337/DB13-0384

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

ResearchGate publication ID

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