(Q37674602)

21 August 2017

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title

Use of intrinsic clearance for prediction of human hepatic clearance (English)

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21 August 2017

Piyun Chao

1

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21 August 2017

Annette S Uss

series ordinal

2

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21 August 2017

K C Cheng

series ordinal

3

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21 August 2017

language of work or name

English

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publication date

1 February 2010

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Expert Opinion on Drug Metabolism & Toxicology

21 August 2017

published in

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21 August 2017

volume

6

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21 August 2017

issue

2

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21 August 2017

page(s)

189-198

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Prediction of pharmacokinetic properties using experimental approaches during early drug discovery

21 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Real-time fluorescence detection of multiple microscale cell culture analog devices in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Development of a microscale cell culture analog to probe naphthalene toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

The P450 gene superfamily: recommended nomenclature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Uncommon P450-catalyzed reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Factors affecting drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Clearance concepts in pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Enhanced maintenance and functions of rat hepatocytes induced by combination of on-site oxygenation and coculture with fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Microscale culture of human liver cells for drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Perfusion and chemical monitoring of living cells on a microfluidic chip

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

A microfluidic 3D hepatocyte chip for drug toxicity testing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Study of osteoblastic cells in a microfluidic environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

A microfluidic platform for 3-dimensional cell culture and cell-based assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Microfabricated grooved substrates as platforms for bioartificial liver reactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

PDMS absorption of small molecules and consequences in microfluidic applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Development and characterization of a small-scale bioreactor based on a bioartificial hepatic culture model for predictive pharmacological in vitro screenings.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Improved Determination of Drug Metabolism by Perifusion of Recombinant V79 Cells Carrying Human CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Longterm stability of phase I and phase II enzymes of porcine liver cells in flat membrane bioreactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Determination of drug binding to plasma proteins using competitive equilibrium binding to dextran-coated charcoal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Correlation between PAMPA permeability and cellular activities of hepatitis C virus protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

Misuse of the well-stirred model of hepatic drug clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903405622

10.1517/17425250903405622

21 January 2018

Identifiers

DOI

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21 August 2017

1 reference