(Q37676063)

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Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension.

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27 December 2019

Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension (English)

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27 December 2019

arterial hypertension

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3

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27 December 2019

author name string

Shruti Sharma

1

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27 December 2019

Neetu Sud

2

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27 December 2019

A Lee Carter

4

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27 December 2019

Sanjiv Kumar

5

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27 December 2019

Yali Hou

6

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27 December 2019

Thomas Rau

7

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27 December 2019

Jason Wilham

8

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27 December 2019

Cynthia Harmon

9

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27 December 2019

Peter Oishi

10

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27 December 2019

Jeffrey R Fineman

11

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27 December 2019

Stephen M Black

12

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27 December 2019

publication date

16 November 2007

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27 December 2019

American Journal of Physiology - Lung Cellular and Molecular Physiology

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27 December 2019

294

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27 December 2019

1

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27 December 2019

L46-56

1 reference

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PMC publication ID

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27 December 2019

Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Mitochondrial uncoupling proteins in the CNS: in support of function and survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Endothelin-1 in congenital heart disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Carnitine replacement in end-stage renal disease and hemodialysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Mitochondrial uncoupling as a therapeutic target following neuronal injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Regulation and role of the mitochondrial transcription factor in the diabetic rat heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Roles of mitochondria in health and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Neurodegenerative diseases and oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Mitochondria and ischemic reperfusion damage in the adult and in the developing brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Neonatal blood carnitine concentrations: normative data by electrospray tandem mass spectometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Mitochondria as a pharmacological target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Mitochondrial contributions to tissue damage in stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Carnitine biosynthesis in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Mitochondrial proton leak: a role for uncoupling proteins 2 and 3?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Upregulation of nitric oxide synthase correlates temporally with onset of pulmonary vascular remodeling in the hypoxic rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

23 August 2017

New genetic defects in mitochondrial fatty acid oxidation and carnitine deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

14 September 2017

The mitochondrial production of reactive oxygen species in relation to aging and pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

14 September 2017

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

14 September 2017

Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

14 September 2017

Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

28 September 2017

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

28 September 2017

Carnitine palmitoyl transferase I deficiency presenting as a Reye-like syndrome without hypoglycaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

28 September 2017

Propionate mitochondrial toxicity in liver and skeletal muscle: acyl CoA levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

28 September 2017

Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

25 June 2018

Lung mitochondrial dysfunction in pulmonary hypertension syndrome. II. Oxidative stress and inability to improve function with repeated additions of adenosine diphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

25 June 2018

Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

25 June 2018

Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

25 June 2018

Electron-spin-resonance evidence for enzymic reduction of oxygen to a free radical, the superoxide ion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

25 June 2018

Atypical features of the hepatic form of carnitine palmitoyltransferase deficiency in a Hutterite family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

25 June 2018

Acyl-CoA inhibition of adenine nucleotide translocation in ischemic myocardium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

25 June 2018

Endothelial response to stress from exogenous Zn2+ resembles that of NO-mediated nitrosative stress, and is protected by MT-1 overexpression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

1 September 2018

Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

1 September 2018

Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

1 September 2018

Mitochondrial dysfunction and oxidative stress as determinants of cell death/survival in stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

1 September 2018

Uncoupling proteins in human heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

1 September 2018

Effect of streptozotocin-induced diabetes on rat brain mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

1 September 2018

Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

1 September 2018

Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

1 September 2018

Role of oxidative phosphorylation and ATP release in mediating birth-related pulmonary vasodilation in fetal lambs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

1 September 2018

Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

1 September 2018

Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

1 September 2018

In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3970936

1 September 2018

Systolic and Diastolic Ventricular Function Assessed by Pressure-Volume Loops in the Stage 21 Venous Clipped Chick Embryo

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00247.2007

21 January 2018

Carnitine biosynthesis in mammals

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00247.2007

21 January 2018

Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute and prolonged hypoxia attenuate endothelial nitric oxide production in rat pulmonary arteries by different mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine esters in metabolic disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of carnitine, acetylcarnitine, and total carnitine in tissues by high-performance liquid chromatography: the effect of exercise on carnitine homeostasis in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine in human plasma by high-performance liquid chromatography after pre-column derivatization with 1-aminoanthracene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine and ATP cause nitric oxide-dependent pulmonary vasodilation in fetal lambs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic studies of fatty acid oxidation gene expression in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A marked upregulation of uncoupling protein 2 gene expression in adipose tissue of hyperthyroid subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shear stress regulation of endothelial NOS in fetal pulmonary arterial endothelial cells involves PKC

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid enzymatic measurement of blood lactate and pyruvate. Use and significance of metaphosphoric acid as a common precipitant

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversible inhibition of mitochondrial adenosine diphosphate phosphorylation by long chain acyl coenzyme A esters

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propionate inhibition of succinate:CoA ligase (GDP) and the citric acid cycle in mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Dynamic Response of Vascular Endothelial Cells to Fluid Shear Stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. II. Use of detergents and antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18024721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPLUNG.00247.2007

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18024721%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18024721%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18024721%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

ResearchGate publication ID

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