(Q37684793)

22 August 2017

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title

Therapeutic targeting of chemokine interactions in atherosclerosis (English)

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22 August 2017

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Rory R Koenen

1

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Christian Weber

object named as

Christian Weber

series ordinal

2

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publication date

1 February 2010

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Nature Reviews Drug Discovery

22 August 2017

published in

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22 August 2017

volume

9

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22 August 2017

issue

2

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22 August 2017

page(s)

141-153

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The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium

22 August 2017

cites work

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Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity

21 January 2018

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RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium.

21 January 2018

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Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans

21 January 2018

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Membrane-bound CC chemokine inhibitor 35K provides localized inhibition of CC chemokine activity in vitro and in vivo

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Cutting Edge: IFN-Producing Cells Respond to CXCR3 Ligands in the Presence of CXCL12 and Secrete Inflammatory Chemokines upon Activation

21 January 2018

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The immune response in atherosclerosis: a double-edged sword

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Chemokines as mediators of angiogenesis.

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Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

31 March 2020

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Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

31 March 2020

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The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

31 March 2020

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The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3

31 March 2020

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Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.

31 March 2020

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Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation

31 March 2020

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Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

31 March 2020

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Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

31 March 2020

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Differential binding of chemokines to glycosaminoglycan subpopulations

31 March 2020

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Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses

31 March 2020

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Profiling heparin-chemokine interactions using synthetic tools

31 March 2020

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Differential immobilization and hierarchical involvement of chemokines in monocyte arrest and transmigration on inflamed endothelium in shear flow

31 March 2020

2 references

31 March 2020

12 December 2020

Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

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Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and T(H)1-like/CD45RO(+) T cells.

31 March 2020

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Three-dimensional structures of alpha and beta chemokines.

31 March 2020

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Neutrophil activation by monomeric interleukin-8.

31 March 2020

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Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines

31 March 2020

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Dimer dissociation is essential for interleukin-8 (IL-8) binding to CXCR1 receptor

31 March 2020

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Probing receptor binding activity of interleukin-8 dimer using a disulfide trap

31 March 2020

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A kinetics and modeling study of RANTES(9-68) binding to heparin reveals a mechanism of cooperative oligomerization

31 March 2020

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Glycosaminoglycans Mediate Cell Surface Oligomerization of Chemokines

31 March 2020

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Structural and functional analysis of the RANTES-glycosaminoglycans interactions

31 March 2020

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The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity

31 March 2020

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Oligomerization of RANTES is required for CCR1-mediated arrest but not CCR5-mediated transmigration of leukocytes on inflamed endothelium

31 March 2020

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Examination of the function of RANTES, MIP-1alpha, and MIP-1beta following interaction with heparin-like glycosaminoglycans

31 March 2020

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Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses

31 March 2020

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Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

31 March 2020

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Chemokines at large: in-vivo mechanisms of their transport, presentation and clearance

31 March 2020

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The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity

31 March 2020

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Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection

31 March 2020

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CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

31 March 2020

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Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury

31 March 2020

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A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation

31 March 2020

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Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E.

31 March 2020

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The platelet microparticle proteome

31 March 2020

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Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium

31 March 2020

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Differential and additive effects of platelet-derived chemokines on monocyte arrest on inflamed endothelium under flow conditions

31 March 2020

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Platelet-derived CXC chemokines: old players in new games

31 March 2020

2 references

31 March 2020

12 December 2020

Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium

1 reference

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

31 March 2020

1 reference

Fine-tuning leukocyte responses: towards a chemokine 'interactome'

31 March 2020

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Chemokine: receptor structure, interactions, and antagonism

31 March 2020

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A rich chemokine environment strongly enhances leukocyte migration and activities

31 March 2020

1 reference

CCL22-induced responses are powerfully enhanced by synergy inducing chemokines via CCR4: evidence for the involvement of first beta-strand of chemokine.

31 March 2020

1 reference

CXC and CC chemokines form mixed heterodimers: association free energies from molecular dynamics simulations and experimental correlations

31 March 2020

1 reference

The inducible CXCR3 ligands control plasmacytoid dendritic cell responsiveness to the constitutive chemokine stromal cell-derived factor 1 (SDF-1)/CXCL12

31 March 2020

1 reference

Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events.

31 March 2020

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Synergy-inducing chemokines enhance CCR2 ligand activities on monocytes

31 March 2020

1 reference

Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer

31 March 2020

1 reference

Platelet factor 4 promotes adhesion of hematopoietic progenitor cells and binds IL-8: novel mechanisms for modulation of hematopoiesis

31 March 2020

1 reference

Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level

31 March 2020

1 reference

Heterodimerization of CCR2 chemokines and regulation by glycosaminoglycan binding

31 March 2020

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Chapter 2. Homo- and hetero-oligomerization of chemokines

31 March 2020

1 reference

Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis

31 March 2020

1 reference

Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice

31 March 2020

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Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines

31 March 2020

1 reference

Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression.

31 March 2020

1 reference

Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody.

31 March 2020

1 reference

The role of chemokines in atherosclerosis: recent evidence from experimental models and population genetics

31 March 2020

1 reference

CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-gamma production, and macrophage accumulation in the aortic wall

31 March 2020

1 reference

Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivo

31 March 2020

1 reference

Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells

31 March 2020

1 reference

CXCR3 antagonist NBI-74330 attenuates atherosclerotic plaque formation in LDL receptor-deficient mice

31 March 2020

1 reference

Measles virus nucleoprotein induces a regulatory immune response and reduces atherosclerosis in mice

31 March 2020

1 reference

Role of Bone Marrow–Derived CC-Chemokine Receptor 5 in the Development of Atherosclerosis of Low-Density Lipoprotein Receptor Knockout Mice

31 March 2020

1 reference

Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice

31 March 2020

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Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction

31 March 2020

1 reference

Mouse models for atherosclerosis and pharmaceutical modifiers.

31 March 2020

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Carotid atherosclerotic plaques stabilize after stroke: insights into the natural process of atherosclerotic plaque stabilization.

31 March 2020

1 reference

Stromal cell-derived factor-1alpha in unstable angina: potential antiinflammatory and matrix-stabilizing effects

31 March 2020

1 reference

CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms

31 March 2020

1 reference

Chemokines in cardiovascular risk prediction

31 March 2020

1 reference

RANTES gene polymorphisms predict all-cause and cardiac mortality in type 2 diabetes mellitus hemodialysis patients

31 March 2020

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Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosis

31 March 2020

1 reference

Opposite effects of CX3CR1 receptor polymorphisms V249I and T280M on the development of acute coronary syndrome. A possible implication of fractalkine in inflammatory activation.

31 March 2020

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Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis

31 March 2020

1 reference

The nuclear protein HMGB1, a new kind of chemokine?

31 March 2020

1 reference

MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis

31 March 2020

1 reference

Stabilization of Atherosclerotic Plaques by Blockade of Macrophage Migration Inhibitory Factor After Vascular Injury in Apolipoprotein E–Deficient Mice

31 March 2020

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Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF)

31 March 2020

1 reference

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

31 March 2020

1 reference

MIF as a glucocorticoid-induced modulator of cytokine production

31 March 2020

1 reference

SDF-1α/CXCR4 Axis Is Instrumental in Neointimal Hyperplasia and Recruitment of Smooth Muscle Progenitor Cells

31 March 2020

1 reference

New therapeutics that modulate chemokine networks

31 March 2020

1 reference

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment

31 March 2020

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Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residues

31 March 2020

1 reference

Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist.

31 March 2020

1 reference

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

31 March 2020

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Amino-terminally modified RANTES analogues demonstrate differential effects on RANTES receptors

31 March 2020

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Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: blocking monocyte arrest and recruitment

31 March 2020

1 reference

The chemokine receptor antagonist AOP-RANTES reduces monocyte infiltration in experimental glomerulonephritis

31 March 2020

1 reference

Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice

31 March 2020

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Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

31 March 2020

1 reference

Blocking CC chemokine receptor (CCR) 1 and CCR5 during herpes simplex virus type 2 infection in vivo impairs host defence and perturbs the cytokine response

31 March 2020

1 reference

An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo.

31 March 2020

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Interference with heparin binding and oligomerization creates a novel anti-inflammatory strategy targeting the chemokine system

31 March 2020

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A Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions in Mice

31 March 2020

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Developing chemokine mutants with improved proteoglycan affinity and knocked-out GPCR activity as anti-inflammatory recombinant drugs.

31 March 2020

1 reference

Surfen, a small molecule antagonist of heparan sulfate

31 March 2020

1 reference

Ticks produce highly selective chemokine binding proteins with antiinflammatory activity

31 March 2020

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The chemokine decoy receptor M3 blocks CC chemokine ligand 2 and CXC chemokine ligand 13 function in vivo

31 March 2020

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HIV entry inhibitor TAK-779 attenuates atherogenesis in low-density lipoprotein receptor-deficient mice

31 March 2020

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CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration

31 March 2020

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A small molecule CXCR4 antagonist inhibits neointima formation and smooth muscle progenitor cell mobilization after arterial injury

31 March 2020

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Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis.

31 March 2020

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Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity

31 March 2020

1 reference

Chemokine receptor antagonists: overcoming developmental hurdles

31 March 2020

1 reference

Infectious complications of tumor necrosis factor blockade

31 March 2020

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Glucocorticoids and invasive fungal infections

31 March 2020

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Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients

31 March 2020

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Effect of torcetrapib on the progression of coronary atherosclerosis

31 March 2020

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Where now for new drugs for atherosclerosis?

31 March 2020

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Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial

31 March 2020

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Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein

31 March 2020

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Structural diversity of heparan sulfate binding domains in chemokines

31 March 2020

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The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models

31 March 2020

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Natural regulatory T cells control the development of atherosclerosis in mice

31 March 2020

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Blood monocytes consist of two principal subsets with distinct migratory properties

31 March 2020

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Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

31 March 2020

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Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis

31 March 2020

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Accumulation of Myeloperoxidase-Positive Neutrophils in Atherosclerotic Lesions in LDLR −/− Mice

31 March 2020

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Perivascular Mast Cells Promote Atherogenesis and Induce Plaque Destabilization in Apolipoprotein E–Deficient Mice

31 March 2020

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Mast cells promote atherosclerosis by releasing proinflammatory cytokines

31 March 2020

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Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression

31 March 2020

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12 December 2020

Interleukin-8 antagonists generated by N-terminal modification

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12 December 2020

Prelesional events in atherogenesis. Accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit

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12 December 2020

Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles

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12 December 2020

Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: cross-talk between MCP-1 and leukotriene B4

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12 December 2020

Chemokine receptor CCR1 disruption in bone marrow cells enhances atherosclerotic lesion development and inflammation in mice

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12 December 2020

CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers.

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12 December 2020

Identifiers

DOI

10.1038/NRD3048

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22 August 2017

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