(Q34515897)

2 August 2017

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title

MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis (English)

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2 August 2017

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2

Michelle Leech

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2 August 2017

Eric F Morand

1

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PubMed ID

16628200

2 August 2017

Jürgen Bernhagen

series ordinal

3

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2 August 2017

1 May 2006

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Nature Reviews Drug Discovery

2 August 2017

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2 August 2017

5

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2 August 2017

399-410

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2 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrd2029

2 August 2017

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cites work

The many roles of chemokines and chemokine receptors in inflammation

1 reference

Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction

31 March 2020

1 reference

Characterization of murine macrophage migration inhibitory activities (MIF) released by concanavalin A stimulated thymus or spleen cells

31 March 2020

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Therapeutic strategies for rheumatoid arthritis

31 March 2020

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Involvement of macrophage migration inhibitory factor in the evolution of rat adjuvant arthritis

31 March 2020

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Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant-induced arthritis

31 March 2020

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Role of macrophage migration inhibitory factor (MIF) in murine antigen-induced arthritis: interaction with glucocorticoids

31 March 2020

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An essential role for macrophage migration inhibitory factor in the tuberculin delayed-type hypersensitivity reaction

31 March 2020

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Macrophage migration inhibitory factor up-regulates the expression of interleukin-8 messenger RNA in synovial fibroblasts of rheumatoid arthritis patients: common transcriptional regulatory mechanism between interleukin-8 and interleukin-1beta

31 March 2020

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Inhibition of joint inflammation and destruction induced by anti-type II collagen antibody/lipopolysaccharide (LPS)-induced arthritis in mice due to deletion of macrophage migration inhibitory factor (MIF).

31 March 2020

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Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis

31 March 2020

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Reduced leukocyte-endothelial cell interactions in the inflamed microcirculation of macrophage migration inhibitory factor-deficient mice.

31 March 2020

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Macrophage migration inhibitory factor in rheumatoid arthritis: evidence of proinflammatory function and regulation by glucocorticoids

31 March 2020

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High expression of macrophage migration inhibitory factor in the synovial tissues of rheumatoid joints

31 March 2020

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Macrophage migration inhibitory factor in rheumatoid arthritis: clinical correlations

31 March 2020

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Regulation of synoviocyte phospholipase A2 and cyclooxygenase 2 by macrophage migration inhibitory factor

31 March 2020

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Macrophage migration inhibitory factor up-regulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis

31 March 2020

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Macrophage migration inhibitory factor up-regulates matrix metalloproteinase-9 and -13 in rat osteoblasts. Relevance to intracellular signaling pathways

31 March 2020

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Control of fibroblast-like synoviocyte proliferation by macrophage migration inhibitory factor

31 March 2020

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Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response

31 March 2020

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A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis

31 March 2020

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Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor

31 March 2020

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A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis.

31 March 2020

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Macrophage Migration Inhibitory Factor Gene Polymorphism is Associated with Psoriasis

31 March 2020

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Association of the -173 G/C polymorphism of the macrophage migration inhibitory factor gene with ulcerative colitis

31 March 2020

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Inflammation in atherosclerosis

31 March 2020

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31 March 2020

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The pathogenesis of atherosclerosis: a perspective for the 1990s

31 March 2020

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Atherosclerosis — An Inflammatory Disease

31 March 2020

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Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease

31 March 2020

1 reference

Innate and adaptive immunity in the pathogenesis of atherosclerosis

31 March 2020

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Mechanisms of monocyte recruitment in vascular repair after injury

31 March 2020

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Expression of macrophage migration inhibitory factor in different stages of human atherosclerosis

31 March 2020

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Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF)

31 March 2020

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De novo expression of macrophage migration inhibitory factor in atherogenesis in rabbits

31 March 2020

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Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice

31 March 2020

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Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation

31 March 2020

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Inflammation, neointimal hyperplasia, and restenosis: as the leukocytes roll, the arteries thicken

31 March 2020

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Evidence for a role of macrophage migration inhibitory factor in vascular disease

31 March 2020

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Stabilization of Atherosclerotic Plaques by Blockade of Macrophage Migration Inhibitory Factor After Vascular Injury in Apolipoprotein E–Deficient Mice

31 March 2020

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Macrophage migration inhibitory factor is associated with aneurysmal expansion

31 March 2020

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Enhancement of oxidised low-density lipoprotein uptake by macrophages in response to macrophage migration inhibitory factor

31 March 2020

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Up-regulation and coexpression of MIF and matrix metalloproteinases in human abdominal aortic aneurysms.

31 March 2020

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Macrophage migration inhibitory factor induces MMP-9 expression: implications for destabilization of human atherosclerotic plaques

31 March 2020

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Evidence for vascular macrophage migration inhibitory factor in destabilization of human atherosclerotic plaques

31 March 2020

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Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages

31 March 2020

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A proinflammatory cytokine inhibits p53 tumor suppressor activity

31 March 2020

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Regulation of arthritis by p53: critical role of adaptive immunity

31 March 2020

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Endogenous p53 Protects Vascular Smooth Muscle Cells From Apoptosis and Reduces Atherosclerosis in ApoE Knockout Mice

31 March 2020

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Premature coronary-artery atherosclerosis in systemic lupus erythematosus

31 March 2020

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Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosus

31 March 2020

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Accelerated atherosclerosis: an extraarticular feature of rheumatoid arthritis?

31 March 2020

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High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors

31 March 2020

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Use of oral corticosteroids in the community and the prevention of secondary osteoporosis: a cross sectional study

31 March 2020

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Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition

31 March 2020

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Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis.

31 March 2020

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Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

31 March 2020

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Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression

31 March 2020

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Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice

31 March 2020

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Transient corticosteroid treatment permanently amplifies the Th2 response in a murine model of asthma

31 March 2020

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MIF as a glucocorticoid-induced modulator of cytokine production

31 March 2020

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Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1.

31 March 2020

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Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase-1 and p38 MAP kinase.

31 March 2020

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Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

31 March 2020

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Enhancing versus suppressive effects of stress hormones on skin immune function

31 March 2020

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Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

31 March 2020

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Anti-inflammatory actions of glucocorticoids: molecular mechanisms

31 March 2020

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Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing's disease during active disease and 1 year after disease remission

31 March 2020

1 reference

The metabolic syndrome and cardiovascular risk in Cushing's syndrome

31 March 2020

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Elevated plasma endothelin as an additional cardiovascular risk factor in patients with Cushing's syndrome

31 March 2020

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Cortisol in urine and saliva: relations to the intima media thickness, IMT.

31 March 2020

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Isoform-specific modulation of coronary artery PKC by glucocorticoids.

31 March 2020

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11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

31 March 2020

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Future prospects for anti-cytokine treatment

31 March 2020

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Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases

31 March 2020

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The use of TNF-alpha blocking agents in rheumatoid arthritis: an overview

31 March 2020

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Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention

31 March 2020

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Protection from septic shock by neutralization of macrophage migration inhibitory factor

31 March 2020

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MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia

31 March 2020

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Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis

31 March 2020

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MIF signal transduction initiated by binding to CD74

31 March 2020

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Inhibition of macrophage migration inhibitory factor decreases proliferation and cytokine expression in bladder cancer cells

31 March 2020

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Anti-TNF-alpha therapies: the next generation

31 March 2020

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Link between macrophage migration inhibitory factor and cellular redox regulation

31 March 2020

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Disulfide analysis reveals a role for macrophage migration inhibitory factor (MIF) as thiol-protein oxidoreductase.

31 March 2020

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The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

31 March 2020

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Direct link between cytokine activity and a catalytic site for macrophage migration inhibitory factor

31 March 2020

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Biochemical and Mutational Investigations of the Enzymatic Activity of Macrophage Migration Inhibitory Factor†

31 March 2020

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Enzymatically inactive macrophage migration inhibitory factor inhibits monocyte chemotaxis and random migration

31 March 2020

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Characterization of catalytic centre mutants of macrophage migration inhibitory factor (MIF) and comparison to Cys81Ser MIF

31 March 2020

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Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1

31 March 2020

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Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor

31 March 2020

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Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity

31 March 2020

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Re-examining the oligomerization state of macrophage migration inhibitory factor (MIF) in solution.

31 March 2020

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Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii.

31 March 2020

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Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition

31 March 2020

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Macrophage migration inhibitory factor and the discovery of tautomerase inhibitors

31 March 2020

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Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity.

31 March 2020

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The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents

31 March 2020

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Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites

31 March 2020

1 reference

Some insights into the stereochemistry of inhibition of macrophage migration inhibitory factor with 2-fluoro-p-hydroxycinnamate and its analogues from molecular dynamics simulations

31 March 2020

1 reference

A 16-residue peptide fragment of macrophage migration inhibitory factor, MIF-(50-65), exhibits redox activity and has MIF-like biological functions

31 March 2020

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Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation

31 March 2020

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Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway

31 March 2020

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The cytokine macrophage migration inhibitory factor reduces pro-oxidative stress-induced apoptosis

31 March 2020

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JAB1/CSN5 and the COP9 signalosome. A complex situation

31 March 2020

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Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium

31 March 2020

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Rho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1.

31 March 2020

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Regulation of macrophage migration inhibitory factor and thiol-specific antioxidant protein PAG by direct interaction

31 March 2020

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Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity

31 March 2020

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MIF regulates innate immune responses through modulation of Toll-like receptor 4

31 March 2020

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ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis

31 March 2020

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Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes

31 March 2020

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An essential regulatory role for macrophage migration inhibitory factor in T-cell activation.

31 March 2020

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The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor

31 March 2020

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Sustained mitogen-activated protein kinase (MAPK) and cytoplasmic phospholipase A2 activation by macrophage migration inhibitory factor (MIF). Regulatory role in cell proliferation and glucocorticoid action

31 March 2020

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An essential role for macrophage migration inhibitory factor (MIF) in angiogenesis and the growth of a murine lymphoma.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD2029

1 reference

2 August 2017

1 reference

PubMed ID

16628200