(Q37692593)

English

Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells

scientific article published on 09 January 2014

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scholarly article

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Europe PubMed Central

PMC publication ID

22 August 2017

Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells (English)

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Europe PubMed Central

PMC publication ID

22 August 2017

James A. McCubrey

7

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31 May 2020

Linda S Steelman

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Linda S Steelman

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31 May 2020

Melissa Sokolosky

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Melissa Sokolosky

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31 May 2020

Kristin Stadelman

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31 May 2020

Stephen L Abrams

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Stephen L Abrams

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31 May 2020

William H Chappell

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William H Chappell

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31 May 2020

Nicole M. Davis

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Nicole M Davis

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31 May 2020

publication date

9 January 2014

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22 August 2017

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31 May 2020

13

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31 May 2020

5

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31 May 2020

820-833

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31 May 2020

describes a project that uses

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11 June 2022

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based on heuristic

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Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.

1 reference

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1 reference

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1 reference

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23 August 2017

Effects of ectopic expression of NGAL on doxorubicin sensitivity

1 reference

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23 August 2017

Mesenchymal traits are selected along with stem features in breast cancer cells grown as mammospheres

1 reference

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23 August 2017

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance

1 reference

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23 August 2017

Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

1 reference

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The role of S6K1 in ER-positive breast cancer

1 reference

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23 August 2017

BRCA1/p220 loss triggers BRCA1-IRIS overexpression via mRNA stabilization in breast cancer cells

1 reference

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23 August 2017

The specific role of pRb in p16 (INK4A) -mediated arrest of normal and malignant human breast cells

1 reference

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23 August 2017

Will PI3K pathway inhibitors be effective as single agents in patients with cancer?

1 reference

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23 August 2017

Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation

1 reference

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23 August 2017

Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells

1 reference

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23 August 2017

Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

Elevated PI3K signaling drives multiple breast cancer subtypes

1 reference

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23 August 2017

Network modeling of MDM2 inhibitor-oxaliplatin combination reveals biological synergy in wt-p53 solid tumors

1 reference

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23 August 2017

Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

MDM2 promoter SNP285 and SNP309; phylogeny and impact on cancer risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

Rare BRCA1 haplotypes including 3'UTR SNPs associated with breast cancer risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

The role of glycogen synthase kinase 3 beta in the transformation of epidermal cells

1 reference

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23 August 2017

Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: functional effects in apoptosis

1 reference

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23 August 2017

Glycogen synthase kinase-3--an overview of an over-achieving protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation

1 reference

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23 August 2017

Targeting GSK-3: a promising approach for cancer therapy?

1 reference

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23 August 2017

Pharmacological breast cancer therapy (review).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

23 August 2017

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

1 reference

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23 August 2017

Creation of human tumour cells with defined genetic elements

1 reference

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23 August 2017

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1 reference

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23 August 2017

Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

1 reference

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23 August 2017

Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase

1 reference

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23 August 2017

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1 reference

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23 August 2017

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1 reference

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23 August 2017

Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment.

1 reference

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6 September 2017

ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer

1 reference

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6 September 2017

RB1 and p53 at the crossroad of EMT and triple-negative breast cancer.

1 reference

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6 September 2017

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14 September 2017

Overexpression of glycogen synthase kinase-3 in ovarian carcinoma cells with acquired paclitaxel resistance

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1 reference

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14 September 2017

GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

14 September 2017

Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.

1 reference

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14 September 2017

Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

14 September 2017

Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979918

14 September 2017

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23 June 2018

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1 reference

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23 June 2018

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1 reference

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Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

1 reference

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1 reference

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1 September 2018

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1 reference

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1 September 2018

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1 reference

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1 September 2018

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1 September 2018

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1 reference

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1 reference

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1 September 2018

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1 reference

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Paclitaxel in doxorubicin-resistant metastatic breast cancer patients.

1 reference

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1 reference

https://api.crossref.org/works/10.4161%2FCC.27728

21 January 2018

Identifiers

10.4161/CC.27728

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24407515%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24407515%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24407515%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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