(Q37697589)

22 August 2017

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title

Regulatory T cells: roles of T cell receptor for their development and function (English)

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22 August 2017

2

Shimon Sakaguchi

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22 August 2017

Naganari Ohkura

1

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22 August 2017

24 February 2010

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Seminars in Immunopathology

22 August 2017

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22 August 2017

32

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22 August 2017

95-106

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22 August 2017

2

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https://scigraph.springernature.com/pub.10.1007/s00281-010-0200-5

22 August 2017

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cites work

Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0200-5

IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0200-5

NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0200-5

CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-010-0200-5

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

21 January 2018

1 reference

12 December 2020

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

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12 December 2020

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

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12 December 2020

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid

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12 December 2020

TCR repertoire and Foxp3 expression define functionally distinct subsets of CD4+ regulatory T cells

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12 December 2020

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

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12 December 2020

Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells

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12 December 2020

Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression

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12 December 2020

LAT-mediated signaling in CD4+CD25+ regulatory T cell development

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12 December 2020

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

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12 December 2020

Coordinated histone modifications mediated by a CtBP co-repressor complex

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12 December 2020

Transcription factors of the NFAT family: regulation and function

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12 December 2020

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

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12 December 2020

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

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12 December 2020

Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression

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12 December 2020

Dependence of self-tolerance on TRAF6-directed development of thymic stroma

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12 December 2020

CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes

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12 December 2020

Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

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12 December 2020

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

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12 December 2020

CD103+ GALT DCs promote Foxp3+ regulatory T cells

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12 December 2020

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

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12 December 2020

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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12 December 2020

FOXP3 actively represses transcription by recruiting the HAT/HDAC complex

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12 December 2020

Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis.

1 reference

12 December 2020

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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12 December 2020

Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer

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12 December 2020

Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression

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12 December 2020

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

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12 December 2020

Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.

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12 December 2020

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

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12 December 2020

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

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12 December 2020

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

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12 December 2020

Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

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12 December 2020

Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells

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12 December 2020

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

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12 December 2020

Runx proteins regulate Foxp3 expression

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12 December 2020

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

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12 December 2020

Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells

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12 December 2020

Foxp3-dependent programme of regulatory T-cell differentiation

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12 December 2020

Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT

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12 December 2020

How regulatory T cells work

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12 December 2020

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

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12 December 2020

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

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12 December 2020

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

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12 December 2020

FOXP3 acts as a rheostat of the immune response

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12 December 2020

CTLA-4 control over Foxp3+ regulatory T cell function

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12 December 2020

CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.

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12 December 2020

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

1 reference

12 December 2020

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

1 reference

12 December 2020

An essential role for Scurfin in CD4+CD25+ T regulatory cells

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12 December 2020

CD4+CD25+ regulatory T cells are activated in vivo by recognition of self

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12 December 2020

CTLA-4-Ig regulates tryptophan catabolism in vivo.

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12 December 2020

Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia

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12 December 2020

An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis

1 reference

12 December 2020

Dynamics of peripheral tolerance and immune regulation mediated by Treg.

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12 December 2020

Activated CD4+CD25+ T cells selectively kill B lymphocytes

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12 December 2020

A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis

1 reference

12 December 2020

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses

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12 December 2020

Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting.

1 reference

12 December 2020

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

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12 December 2020

The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation

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12 December 2020

Regulatory T cells - a brief history and perspective

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12 December 2020

Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking

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12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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12 December 2020

Control of regulatory T cell development by the transcription factor Foxp3

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12 December 2020

A function for interleukin 2 in Foxp3-expressing regulatory T cells

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12 December 2020

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

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12 December 2020

In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

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12 December 2020

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

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12 December 2020

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

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12 December 2020

Transforming growth factor-beta induces development of the T(H)17 lineage

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12 December 2020

Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat

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12 December 2020

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

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12 December 2020

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

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12 December 2020

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

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12 December 2020

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

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12 December 2020

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

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12 December 2020

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

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12 December 2020

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12 December 2020

Calcineurin: a central controller of signalling in eukaryotes

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12 December 2020

Th17 cells and mucosal host defense

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12 December 2020

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

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12 December 2020

Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice.

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12 December 2020

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

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12 December 2020

Differentiation and function of Th17 T cells

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12 December 2020

Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor.

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12 December 2020

Epigenetic control of the foxp3 locus in regulatory T cells

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12 December 2020

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

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12 December 2020

Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice.

1 reference

12 December 2020

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

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12 December 2020

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes

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12 December 2020

FOXP3 controls regulatory T cell function through cooperation with NFAT

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12 December 2020

Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1.

1 reference

12 December 2020

The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells

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12 December 2020

Regulatory T cells: how do they suppress immune responses?

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12 December 2020

Causal relationship between the loss of RUNX3 expression and gastric cancer

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12 December 2020

Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells

1 reference

12 December 2020

Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?

1 reference

12 December 2020

RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes

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12 December 2020

FOXP3: of mice and men.

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12 December 2020

Tolerance, not immunity, crucially depends on IL-2.

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12 December 2020

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

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12 December 2020

Mechanisms of foxp3+ T regulatory cell-mediated suppression

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12 December 2020

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

1 reference

12 December 2020

10.1007/S00281-010-0200-5

Identifiers

DOI

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22 August 2017

1 reference

PubMed ID

20179931