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Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
scientific article published on July 2013
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Europe PubMed Central
PMC publication ID
3984536
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23836234%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3984536
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23836234%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
main subject
Hepatitis C virus
1 reference
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virus
0 references
hepatitis C
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inferred from title
author
Troels K Scheel
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
3984536
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23836234%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
Charles M. Rice
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2
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Charles M Rice
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Europe PubMed Central
PMC publication ID
3984536
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23836234%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
language of work or name
English
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publication date
1 July 2013
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Europe PubMed Central
PMC publication ID
3984536
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23836234%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
published in
Nature Medicine
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stated in
Europe PubMed Central
PMC publication ID
3984536
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23836234%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
volume
19
1 reference
stated in
Europe PubMed Central
PMC publication ID
3984536
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23836234%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
issue
7
1 reference
stated in
Europe PubMed Central
PMC publication ID
3984536
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23836234%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
page(s)
837-849
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Europe PubMed Central
PMC publication ID
3984536
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23836234%20AND%20SRC:MED&resulttype=core&format=json
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4 March 2020
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Apolipoprotein E but Not B Is Required for the Formation of Infectious Hepatitis C Virus Particles
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23 August 2017
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
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23 August 2017
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
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PubMed Central
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23 August 2017
Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis
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23 August 2017
Treatment predictors of a sustained virologic response in hepatitis B and C.
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23 August 2017
Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems
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23 August 2017
Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro
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23 August 2017
Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly
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23 August 2017
Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein
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23 August 2017
A virocidal amphipathic -helical peptide that inhibits hepatitis C virus infection in vitro
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23 August 2017
Cellular Determinants of Hepatitis C Virus Assembly, Maturation, Degradation, and Secretion
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23 August 2017
Identification of Residues Required for RNA Replication in Domains II and III of the Hepatitis C Virus NS5A Protein
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23 August 2017
Human Apolipoprotein E Is Required for Infectivity and Production of Hepatitis C Virus in Cell Culture
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23 August 2017
Cell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted Variant
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23 August 2017
Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus
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23 August 2017
The lipid droplet is an important organelle for hepatitis C virus production
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23 August 2017
Assembly of a functional HCV glycoprotein heterodimer.
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23 August 2017
Replication of hepatitis C virus
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23 August 2017
Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Treating viral hepatitis C: efficacy, side effects, and complications
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Hepatitis C Virus Entry Depends on Clathrin-Mediated Endocytosis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter Viruses
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PubMed Central
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23 August 2017
Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Mechanism of action of interferon and ribavirin in treatment of hepatitis C
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Complete replication of hepatitis C virus in cell culture
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Robust hepatitis C virus infection in vitro
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23 August 2017
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Characterization of Low- and Very-Low-Density Hepatitis C Virus RNA-Containing Particles
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Hepatitis C virus replication in mice with chimeric human livers
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Efficient initiation of HCV RNA replication in cell culture
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines
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23 August 2017
Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Binding of hepatitis C virus to CD81
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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23 August 2017
Current progress in development of hepatitis C virus vaccines.
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6 September 2017
New therapeutic strategies in HCV: second-generation protease inhibitors
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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6 September 2017
What are the promising new therapies in the field of chronic hepatitis C after the first-generation direct-acting antivirals?
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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6 September 2017
The role of resistance in HCV treatment
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6 September 2017
Animal models for the study of hepatitis C virus infection and related liver disease
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6 September 2017
The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection
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6 September 2017
Steatosis and insulin resistance in response to treatment of chronic hepatitis C.
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6 September 2017
Hepatitis C viral protein translation: mechanisms and implications in developing antivirals.
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6 September 2017
HCV and the hepatic lipid pathway as a potential treatment target
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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6 September 2017
New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B.
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6 September 2017
Assembly of infectious hepatitis C virus particles
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6 September 2017
Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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6 September 2017
Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-α.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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14 September 2017
Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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14 September 2017
Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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14 September 2017
Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo
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14 September 2017
Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel
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14 September 2017
The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly
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14 September 2017
Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo
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14 September 2017
Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture
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14 September 2017
The NS5A protein of hepatitis C virus is a zinc metalloprotein
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14 September 2017
Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
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14 September 2017
Resistance analysis of hepatitis C virus genotype 1 prior treatment null responders receiving daclatasvir and asunaprevir
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23 June 2018
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1
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23 June 2018
Exploratory study of oral combination antiviral therapy for hepatitis C.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
retrieved
1 September 2018
Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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1 September 2018
Daclatasvir for previously untreated chronic hepatitis C genotype-1 infection: a randomised, parallel-group, double-blind, placebo-controlled, dose-finding, phase 2a trial
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
retrieved
1 September 2018
Serum cholesterol and statin use predict virological response to peginterferon and ribavirin therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
retrieved
1 September 2018
The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naïve hepatitis C patients.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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1 September 2018
Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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1 September 2018
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
retrieved
1 September 2018
Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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1 September 2018
Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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1 September 2018
Clinical evaluation (Phase I) of a human monoclonal antibody against hepatitis C virus: safety and antiviral activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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1 September 2018
Structural determinants that target the hepatitis C virus core protein to lipid droplets.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984536
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1 September 2018
Will IL28B polymorphism remain relevant in the era of direct-acting antiviral agents for hepatitis C virus?
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1038%2FNM.3248
retrieved
21 January 2018
Refinement of stopping rules during treatment of hepatitis C genotype 1 infection with boceprevir and peginterferon/ribavirin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM.3248
retrieved
21 January 2018
Identifiers
DOI
10.1038/NM.3248
1 reference
stated in
Europe PubMed Central
PMC publication ID
3984536
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23836234%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
PMC publication ID
3984536
1 reference
stated in
Europe PubMed Central
PMC publication ID
3984536
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23836234%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
PubMed publication ID
23836234
1 reference
stated in
Europe PubMed Central
PMC publication ID
3984536
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23836234%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
ResearchGate publication ID
247772444
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