(Q37701947)

22 August 2017

1 reference

title

Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites? (English)

1 reference

22 August 2017

4

Jos H Beijnen

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22 August 2017

3

Jan H M Schellens

1 reference

22 August 2017

Robert S Jansen

1

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22 August 2017

Hilde Rosing

series ordinal

2

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22 August 2017

publication date

1 April 2011

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Fundamental and Clinical Pharmacology

22 August 2017

published in

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22 August 2017

volume

25

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22 August 2017

issue

2

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22 August 2017

page(s)

172-185

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Antitumor activity of sugar-modified cytosine nucleosides

22 August 2017

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The Mechanism of Action of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Involves a Second Metabolic Pathway Leading to -D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine 5'-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

21 January 2018

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New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine

21 January 2018

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Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species

21 January 2018

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Clinical pharmacokinetics of cytarabine formulations

21 January 2018

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Cytosine arabinoside transport and metabolism in acute leukemias and T cell lymphoblastic lymphoma

21 January 2018

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Detection and determination of the major metabolites of [3H]cytosine arabinoside by high-performance liquid chromatography

21 January 2018

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Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study

21 January 2018

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Extensive metabolism and hepatic accumulation of gemcitabine after multiple oral and intravenous administration in mice

21 January 2018

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Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication

21 January 2018

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Pharmacokinetics of the antiviral agent beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine in rhesus monkeys

21 January 2018

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Antiviral L-nucleosides specific for hepatitis B virus infection

21 January 2018

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Pharmacology of beta-L-thymidine and beta-L-2'-deoxycytidine in HepG2 cells and primary human hepatocytes: relevance to chemotherapeutic efficacy against hepatitis B virus

21 January 2018

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Pharmacology of 5-Aza-2'-deoxycytidine (decitabine).

21 January 2018

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Comparative pharmacokinetics of Racivir, (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats, rabbits, dogs, monkeys and HIV-infected humans

21 January 2018

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Intracellular metabolism of (-)- and (+)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in HepG2 derivative 2.2.15 (subclone P5A) cells

21 January 2018

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In vitro studies on the immunosuppressive effect of 2',2'-difluorodeoxycytidine (dFdC) and its metabolite 2',2'-difluorodeoxyuridine (dFdU).

21 January 2018

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Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates

21 January 2018

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Improved synthesis of zebularine [1-(beta-D-ribofuranosyl)-dihydropyrimidin-2-one] nucleotides as inhibitors of human deoxycytidylate deaminase

21 January 2018

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Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases

21 January 2018

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Assessment of the effect of phosphorylated metabolites of anti-human immunodeficiency virus and anti-hepatitis B virus pyrimidine analogs on the behavior of human deoxycytidylate deaminase

21 January 2018

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Modulation of deoxycytidylate deaminase in intact human leukemia cells. Action of 2',2'-difluorodeoxycytidine

21 January 2018

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Studies on 1-?-D-arabinofuranosyl cytosine-resistant mutants of Chinese hamster fibroblasts: III. Joint resistance to arabinofuranosyl cytosine and to excess thymidine?A semidominant manifestation of deoxycytidine triphosphate pool expansion

21 January 2018

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Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.

21 January 2018

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Biochemical pharmacology and analysis of fluoropyrimidines alone and in combination with modulators

21 January 2018

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Inhibition of deoxyribonucleic acid polymerases from murine cells and oncornavirus by 5-alkylated derivatives of 1-.beta.-D-arabinofuranosyluracil 5'-triphosphate: substituent effects on inhibitory action

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2010.00823.X

2',2'-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2010.00823.X

The incorporation of 5-fluoro-2'-deoxyuridine into DNA of mammalian tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2010.00823.X

The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro

21 January 2018

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Decitabine--bedside to bench

21 January 2018

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Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy

21 January 2018

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Modulation of gemcitabine (2',2'-difluoro-2'-deoxycytidine) pharmacokinetics, metabolism, and bioavailability in mice by 3,4,5,6-tetrahydrouridine.

21 January 2018

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Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2010.00823.X

Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine

21 January 2018

1 reference

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Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia.

21 January 2018

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Characterization of lipophilic gemcitabine prodrug-liposomal membrane interaction by differential scanning calorimetry.

21 January 2018

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CP-4055 and CP-4126 are active in ara-C and gemcitabine-resistant lymphoma cell lines

21 January 2018

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Nucleoside ester prodrug substrate specificity of liver carboxylesterase

21 January 2018

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Antitumoral activity of PEG-gemcitabine prodrugs targeted by folic acid

21 January 2018

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Synthesis and biological activity of a gemcitabine phosphoramidate prodrug

21 January 2018

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Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2010.00823.X

Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2010.00823.X

Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2010.00823.X

Synthesis and anticancer activities of amphiphilic 5-fluoro-2'-deoxyuridylic acid prodrugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2010.00823.X

Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2010.00823.X

10.1111/J.1472-8206.2010.00823.X

21 January 2018

Identifiers

DOI

1 reference

release_ok6xk7ockzbklb2iwvkhmf4lau

22 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ok6xk7ockzbklb2iwvkhmf4lau

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference