(Q37704653)

22 August 2017

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title

Structural genomics-impact on biomedicine and drug discovery (English)

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22 August 2017

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Johan Weigelt

1

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22 August 2017

language of work or name

English

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publication date

6 March 2010

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Experimental Cell Research

22 August 2017

published in

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22 August 2017

volume

316

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22 August 2017

issue

8

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22 August 2017

page(s)

1332-1338

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.02.041

22 August 2017

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An integrated approach to structural genomics.

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SPINE: Structural Proteomics IN Europe – the best of both worlds

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The structural genomics consortium makes its presence known

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High-throughput crystallography for structural genomics

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The Role of Medical Structural Genomics in Discovering New Drugs for Infectious Diseases

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Protein production and purification

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Crystallization data mining in structural genomics: using positive and negative results to optimize protein crystallization screens

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Automated sample mounting and alignment system for biological crystallography at a synchrotron source.

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Automation of the EMBL Hamburg protein crystallography beamline BW7B.

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Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines

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NMR data collection and analysis protocol for high-throughput protein structure determination

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Structural biology and drug discovery

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Structural genomics is the largest contributor of novel structural leverage

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PSI-2: structural genomics to cover protein domain family space.

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Structure-based drug discovery for Plasmodium falciparum

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The TB structural genomics consortium: providing a structural foundation for drug discovery.

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Structural genomics as an approach towards understanding the biology of tuberculosis

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Large-scale structural biology of the human proteome

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The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

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Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

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Development of PARP inhibitors in oncology

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Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

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Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.

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A Protein Structure (or Function ?) Initiative.

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Pushing structural information into the yeast interactome by high-throughput protein docking experiments

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10.1016/J.YEXCR.2010.02.041

7 January 2021

Identifiers

DOI

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22 August 2017

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