(Q37704738)

English

Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6)

scientific article published on 23 October 2013

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scholarly article

1 reference

Europe PubMed Central

22 August 2017

Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6) (English)

1 reference

Europe PubMed Central

22 August 2017

1

object named as

Ku-Lung Hsu

1 reference

Europe PubMed Central

22 August 2017

Benjamin Cravatt

7

object named as

Benjamin F Cravatt

1 reference

Europe PubMed Central

22 August 2017

author name string

Katsunori Tsuboi

2

1 reference

Europe PubMed Central

22 August 2017

Jae Won Chang

3

1 reference

Europe PubMed Central

22 August 2017

Landon R Whitby

4

1 reference

Europe PubMed Central

22 August 2017

Anna E Speers

5

1 reference

Europe PubMed Central

22 August 2017

Holly Pugh

6

1 reference

Europe PubMed Central

22 August 2017

language of work or name

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publication date

23 October 2013

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Europe PubMed Central

22 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

22 August 2017

56

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Europe PubMed Central

22 August 2017

21

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Europe PubMed Central

22 August 2017

8270-8279

1 reference

Europe PubMed Central

22 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3987869/fullTextXML

based on heuristic

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Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis

1 reference

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1 reference

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Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987869

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DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

1 reference

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Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987869

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The metabolic serine hydrolases and their functions in mammalian physiology and disease

1 reference

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Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors

1 reference

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Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

1 reference

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Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

1 reference

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The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

1 reference

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Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987869

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A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

1 reference

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A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

1 reference

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Activity-based protein profiling: the serine hydrolases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987869

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A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987869

1 September 2018

A streamlined platform for high-content functional proteomics of primary human specimens

1 reference

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Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

1 reference

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Profiling serine hydrolase activities in complex proteomes

1 reference

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1 September 2018

Efficient synthesis of 2-substituted-1,2,3-triazoles

1 reference

https://pubmed.ncbi.nlm.nih.gov/24152295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM400899C

1 reference

Europe PubMed Central

22 August 2017

1 reference

Europe PubMed Central

22 August 2017

1 reference

Europe PubMed Central

22 August 2017

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