(Q37708839)

English

The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy.

scientific article published on 06 September 2016

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27612425%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy (English)

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22 March 2020

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colorectal cancer

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

colorectal carcinoma

1 reference

based on heuristic

inferred from title

1

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22 March 2020

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22 March 2020

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Adnan Ahmad Ansari

2

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22 March 2020

Jihun Kim

3

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22 March 2020

Deokhoon Kim

4

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22 March 2020

Jiyun Kim

6

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22 March 2020

Tae Won Kim

7

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22 March 2020

Inja Park

8

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22 March 2020

Chang-Sik Yu

9

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22 March 2020

Se Jin Jang

10

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22 March 2020

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1 October 2016

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22 March 2020

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22 March 2020

7

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22 March 2020

42

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22 March 2020

68638-68649

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27612425%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

1 reference

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23 August 2017

Polymerase ε (POLE) ultra-mutated tumors induce robust tumor-specific CD4+ T cell responses in endometrial cancer patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5356579

23 August 2017

POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

1 reference

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23 August 2017

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

1 reference

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23 August 2017

The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy

1 reference

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23 August 2017

Hypermutation in human cancer genomes: footprints and mechanisms

1 reference

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Early-onset colorectal cancer: a sporadic or inherited disease?

1 reference

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Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012

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New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis

1 reference

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RefSeq: an update on mammalian reference sequences

1 reference

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Properties of MHC class I presented peptides that enhance immunogenicity

1 reference

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PIK3CA and APC mutations are synergistic in the development of intestinal cancers

1 reference

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Integrated genomic characterization of endometrial carcinoma

1 reference

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DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer

1 reference

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23 August 2017

Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers

1 reference

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23 August 2017

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5356579

23 August 2017

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5356579

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Recurrent R-spondin fusions in colon cancer

1 reference

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Comprehensive molecular characterization of human colon and rectal cancer

1 reference

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Mice expressing activated PI3K rapidly develop advanced colon cancer

1 reference

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23 August 2017

LOVD v.2.0: the next generation in gene variant databases

1 reference

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23 August 2017

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

1 reference

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Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci

1 reference

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Microsatellite instability in colorectal cancer

1 reference

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Microsatellite instability in colorectal cancer-the stable evidence

1 reference

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1 reference

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A practical approach to familial and hereditary colorectal cancer

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Rising incidence of early-onset colorectal cancer in Australia over two decades: report and review.

1 reference

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6 September 2017

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1 reference

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1 reference

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1 reference

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1 reference

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10.18632/ONCOTARGET.11862

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27612425%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

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22 March 2020

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22 March 2020

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