(Q37709376)

22 August 2017

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title

Leptin as a potential therapeutic target for breast cancer prevention and treatment (English)

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22 August 2017

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Amitbha Ray

1

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22 August 2017

Margot P Cleary

series ordinal

2

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22 August 2017

language of work or name

English

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publication date

1 April 2010

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Expert Opinion on Therapeutic Targets

22 August 2017

published in

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22 August 2017

volume

14

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22 August 2017

issue

4

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22 August 2017

page(s)

443-451

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Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world

22 August 2017

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https://api.crossref.org/works/10.1517%2F14728221003716466

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21 January 2018

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Obesity as a risk factor for development and poor prognosis of breast cancer

21 January 2018

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Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women

21 January 2018

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Adipose tissue as an endocrine organ

21 January 2018

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Regulation of estrogen synthesis in postmenopausal women

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003716466

Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003716466

Positional cloning of the mouse obese gene and its human homologue

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003716466

Recombinant ob protein reduces feeding and body weight in the ob/ob mouse

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003716466

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin-induced signal transduction pathways.

21 January 2018

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Leptin and the regulation of body weight in mammals

21 January 2018

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Human leptin: from an adipocyte hormone to an endocrine mediator

21 January 2018

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Leptin, reproduction and sex steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Dietary xenoestrogens differentially impair 3T3-L1 preadipocyte differentiation and persistently affect leptin synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Plasma leptin and insulin in C57BI/6J mice on a high-fat diet: relation to subsequent changes in body weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Diet-induced adiposity alters the serum profile of inflammation in C57BL/6N mice as measured by antibody array

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003716466

Gender, smoking during pregnancy and gestational age influence cord leptin concentrations in newborn infants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Identification and expression cloning of a leptin receptor, OB-R

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Divergent signaling capacities of the long and short isoforms of the leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin receptor signal transduction: OBRa and OBRb of fa type

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin receptor signaling and the regulation of mammalian physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Expression of leptin receptor in lung: leptin as a growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

The regulation of leptin gene expression in the C6 glioblastoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin mediates a proliferative response in human MCF7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin Enhances, via AP-1, Expression of Aromatase in the MCF-7 Cell Line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin-regulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Serum adiponectin and leptin levels in Taiwanese breast cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Body weight and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status among Swedish women: A prospective cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Breast cancer risk factors defined by estrogen and progesterone receptor status: the multiethnic cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-alpha mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Diet-induced obesity and mammary tumor development in MMTV-neu female mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Susceptibility of lean and obese Zucker rats to tumorigenesis induced by N-methyl-N-nitrosourea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Obesity promotes 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in female zucker rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Large-scale preparation of biologically active mouse and rat leptins and their L39A/D40A/F41A muteins which act as potent antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Mapping of the leptin binding sites and design of a leptin antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Preparation of leptin antagonists by site-directed mutagenesis of human, ovine, rat, and mouse leptin's site III: implications on blocking undesired leptin action in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Leptin analog antagonizes leptin effects on food intake and body weight but mimics leptin-induced vagal afferent activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Development of leptin antagonists and their potential use in experimental biology and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Development of a pharmacologically improved peptide agonist of the leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Effects of adiponectin on breast cancer cell growth and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Mammary tumor development from T47-D human breast cancer cells in obese ovariectomized mice with and without estradiol supplements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Effects of seafood consumption and weight loss on fasting leptin and ghrelin concentrations in overweight and obese European young adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat-fed hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Isoflavone regulates lipid metabolism via expression of related genes in OVX rats fed on a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Momordica charantia extract on insulin resistance and the skeletal muscle GLUT4 protein in fructose-fed rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Arterial elasticity and plasma levels of adiponectin and leptin in type 2 diabetic patients treated with thiazolidinediones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Effects of pioglitazone and metformin on plasma adiponectin in newly detected type 2 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Adiponectin: a relevant player in PPARgamma-agonist-mediated improvements in hepatic insulin sensitivity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

The anti-obesity effect of rimonabant is associated with an improved serum lipid profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003716466

10.1517/14728221003716466

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference