(Q37710708)

22 August 2017

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title

Mixed lineage leukemia: roles in human malignancies and potential therapy (English)

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22 August 2017

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Rolf Marschalek

1

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22 August 2017

language of work or name

English

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publication date

4 March 2010

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22 August 2017

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22 August 2017

volume

277

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22 August 2017

issue

8

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22 August 2017

page(s)

1822-1831

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Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment

22 August 2017

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1 reference

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The role of HOX genes in malignant myeloid disease

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Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells

21 January 2018

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Cloning and molecular characterization of the trithorax locus of Drosophila melanogaster

21 January 2018

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Molecular characterization of the trithorax gene, a positive regulator of homeotic gene expression in Drosophila

21 January 2018

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Regulation of hematopoietic stem cells by the niche.

21 January 2018

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A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia.

21 January 2018

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21 January 2018

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ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

21 January 2018

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Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

21 January 2018

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Global and Hox-specific roles for the MLL1 methyltransferase

21 January 2018

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Gene transfer into hematopoietic stem cells of nonhuman primates

21 January 2018

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Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.

21 January 2018

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MLL associates specifically with a subset of transcriptionally active target genes

21 January 2018

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Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes

21 January 2018

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Menin critically links MLL proteins with LEDGF on cancer-associated target genes

21 January 2018

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Modulation of cell cycle by graded expression of MLL-AF4 fusion oncoprotein

21 January 2018

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Combined effects of the two reciprocal t(4;11) fusion proteins MLL.AF4 and AF4.MLL confer resistance to apoptosis, cell cycling capacity and growth transformation.

21 January 2018

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Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia.

21 January 2018

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Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients.

21 January 2018

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HOXA9 is required for survival in human MLL-rearranged acute leukemias

21 January 2018

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The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia

21 January 2018

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The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21).

21 January 2018

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New insights to the MLL recombinome of acute leukemias

21 January 2018

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Controlling the elongation phase of transcription with P-TEFb

21 January 2018

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The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

21 January 2018

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H3K79 methylation profiles define murine and human MLL-AF4 leukemias

21 January 2018

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Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275

21 January 2018

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Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

21 January 2018

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Pharmacological inhibitors of cyclin-dependent kinases

21 January 2018

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FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

21 January 2018

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Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.

21 January 2018

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Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation

21 January 2018

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Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

21 January 2018

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Identification of an antiapoptotic protein complex at death receptors

21 January 2018

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Misguided transcriptional elongation causes mixed lineage leukemia

21 January 2018

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HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A

21 January 2018

1 reference

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Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

21 January 2018

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Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

21 January 2018

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Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

21 January 2018

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Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression

21 January 2018

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p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect.

21 January 2018

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KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells

21 January 2018

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KLF4, p21 and context-dependent opposing forces in cancer

21 January 2018

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In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties

21 January 2018

1 reference

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Modeling Chromosomal Translocations Using Conditional Alleles to Recapitulate Initiating Events in Human Leukemias

21 January 2018

1 reference

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10.1111/J.1742-4658.2010.07608.X

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference