(Q37718546)

1 July 2019

2 references

6 August 2019

20 November 2019

Prodrug approach for increasing cellular glutathione levels (English)

1 reference

1 July 2019

pharmaceutical preparation

main subject

1 reference

6 August 2019

1 reference

20 November 2019

1 reference

1

1 reference

1 July 2019

Adriano Mollica

4

1 reference

1 July 2019

Antonio Di Stefano

5

1 reference

1 July 2019

author name string

Catia Cornacchia

2

1 reference

1 July 2019

Francesco Pinnen

3

1 reference

1 July 2019

language of work or name

English

0 references

publication date

3 March 2010

3 references

1 July 2019

6 August 2019

20 November 2019

3 references

1 July 2019

6 August 2019

20 November 2019

15

1 reference

1 July 2019

issue

3

1 reference

1 July 2019

page(s)

1242-1264

1 reference

1 July 2019

Creative Commons Attribution

copyright license

2 references

6 August 2019

20 November 2019

0 references

Protective effect of gamma-glutamylcysteinylethyl ester on dysfunction of the selenium-deficient rat heart

1 reference

12 December 2020

Synthesis and activity of gamma-(L-gamma-azaglutamyl)-S-(p-bromobenzyl)-L-cysteinylglycine: a metabolically stable inhibitor of glyoxalase I

1 reference

12 December 2020

Regulation of hepatic glutathione synthesis: current concepts and controversies.

1 reference

12 December 2020

Reperfusion injury of the liver: role of mitochondria and protection by glutathione ester

1 reference

12 December 2020

Glutathione and its role in cellular functions

1 reference

12 December 2020

Biologic and pharmacologic regulation of mammalian glutathione synthesis

1 reference

12 December 2020

Regulation of glutathione synthesis.

1 reference

12 December 2020

Manganese increases L-DOPA auto-oxidation in the striatum of the freely moving rat: potential implications to L-DOPA long-term therapy of Parkinson's disease.

1 reference

12 December 2020

Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease

1 reference

12 December 2020

Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice

1 reference

12 December 2020

Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione

1 reference

12 December 2020

Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases

1 reference

12 December 2020

Rethinking cystic fibrosis pathology: the critical role of abnormal reduced glutathione (GSH) transport caused by CFTR mutation

1 reference

12 December 2020

Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes

1 reference

12 December 2020

Effects of reduced and oxidized glutathione on sphingomyelinase activity and contents of sphingomyelin and lipid peroxidation products in murine liver

1 reference

12 December 2020

In vivo antioxidant role of glutathione peroxidase: evidence from knockout mice.

1 reference

12 December 2020

Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury

1 reference

12 December 2020

Elevation of brain glutathione by gamma-glutamylcysteine ethyl ester protects against peroxynitrite-induced oxidative stress

1 reference

12 December 2020

Free radicals, antioxidants, and nutrition

1 reference

12 December 2020

Dietary supplementation with cysteine prodrugs selectively restores tissue glutathione levels and redox status in protein-malnourished mice(1).

1 reference

12 December 2020

Inhibition of influenza infection by glutathione

1 reference

12 December 2020

Hepatoprotection by L‐cysteine‐glutathione mixed disulfide, a sulfhydryl‐modified prodrug of glutathione

1 reference

12 December 2020

Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse

1 reference

12 December 2020

Analysis of glutathione: implication in redox and detoxification

1 reference

12 December 2020

The importance of glutathione in human disease

1 reference

12 December 2020

Bucillamine: a potent thiol donor with multiple clinical applications.

1 reference

12 December 2020

The effects of gamma-glutamylcysteine ethyl ester, a prodrug of glutathione, on ischemia-reperfusion-induced liver injury in rats

1 reference

12 December 2020

Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine

1 reference

12 December 2020

General Articles Intracellular Thiol Concentration Modulating Inflammatory Response: Influence on the Regulation of Cell Functions Through Cysteine Prodrug Approach

1 reference

12 December 2020

Glutathione monoethylester prevents mitochondrial glutathione depletion during focal cerebral ischemia.

1 reference

12 December 2020

Effects of S-acetylglutathione in cell and animal model of herpes simplex virus type 1 infection

1 reference

12 December 2020

Glutathione monoethyl ester provides neuroprotection in a rat model of stroke.

1 reference

12 December 2020

Glutathione metabolism and its implications for health

1 reference

12 December 2020

Distribution of iron in different brain regions and subcellular compartments in Parkinson's disease

1 reference

12 December 2020

Biosynthesis of the flavour precursors of onion and garlic

1 reference

12 December 2020

Glutathione metabolism during aging and in Alzheimer disease

1 reference

12 December 2020

Increase in rat brain glutathione following intracerebroventricular administration of gamma-glutamylcysteine

1 reference

12 December 2020

Five cysteine-containing compounds delay diabetic deterioration in Balb/cA mice

1 reference

12 December 2020

N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress

1 reference

12 December 2020

Rational approach to discover multipotent anti-Alzheimer drugs.

1 reference

12 December 2020

Gender differences in glutathione metabolism in Alzheimer's disease

1 reference

12 December 2020

Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving peroxynitrite: implications for Parkinson's disease

1 reference

12 December 2020

Prevention of naphthalene-induced pulmonary toxicity by glutathione prodrugs: roles for glutathione depletion in adduct formation and cell injury.

1 reference

12 December 2020

The effects of stress and aging on glutathione metabolism

1 reference

12 December 2020

Physiological and pathological aspects of GSH metabolism

1 reference

12 December 2020

Alpha-synuclein dysfunction in Lewy body diseases

1 reference

12 December 2020

Protective effect of s-allyl cysteine and s-propyl cysteine on acetaminophen-induced hepatotoxicity in mice

1 reference

12 December 2020

In vitro and in vivo neuroprotection by gamma-glutamylcysteine ethyl ester against MPTP: relevance to the role of glutathione in Parkinson's disease.

1 reference

12 December 2020

A metabolically stable tight-binding transition-state inhibitor of glyoxalase-I

1 reference

12 December 2020

Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's disease

1 reference

12 December 2020

Ten years results of bucillamine in the treatment of rheumatoid arthritis.

1 reference

12 December 2020

Antioxidant UPF1 attenuates myocardial stunning in isolated rat hearts

1 reference

12 December 2020

Inborn errors in the metabolism of glutathione

1 reference

12 December 2020

Synthesis and study of L-dopa-glutathione codrugs as new anti-Parkinson agents with free radical scavenging properties

1 reference

12 December 2020

Antioxidative and anti-inflammatory effects of four cysteine-containing agents in striatum of MPTP-treated mice

1 reference

12 December 2020

Design, synthesis and properties of novel powerful antioxidants, glutathione analogues

1 reference

12 December 2020

N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency

1 reference

12 December 2020

Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid): a role for acetaminophen

1 reference

12 December 2020

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

1 reference

12 December 2020

The cardioprotective effect of γ-glutamylcysteine ethyl ester during coronary reperfusion in canine hearts

1 reference

12 December 2020

The central role of glutathione in the pathophysiology of human diseases

1 reference

12 December 2020

Inhibition of murine AIDS by pro-glutathione (GSH) molecules.

1 reference

12 December 2020

Scope and limitations of the co-drug approach to topical drug delivery.

1 reference

12 December 2020

Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC).

1 reference

12 December 2020

Design, synthesis and biological evaluation of glutathione peptidomimetics as components of anti-Parkinson prodrugs

1 reference

12 December 2020

GSH and analogs in antiviral therapy

1 reference

12 December 2020

Glutathione dysregulation and the etiology and progression of human diseases.

1 reference

12 December 2020

Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfide, and vitamin E.

1 reference

12 December 2020

Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress

1 reference

12 December 2020

L-2-oxothiazolidine-4-carboxylic acid, a cysteine prodrug: pharmacokinetics and effects on thiols in plasma and lymphocytes in human

1 reference

12 December 2020

Systemic glutathione deficiency in symptom-free HIV-seropositive individuals

1 reference

12 December 2020

Modulation of endothelial GSH concentrations: effect of exogenous GSH and GSH monoethyl ester

1 reference

12 December 2020

Methods for the selective modification of glutathione metabolism and study of glutathione transport

1 reference

12 December 2020

Glutathione metabolism and its selective modification

1 reference

12 December 2020

Amino acids, glutathione, and glutathione transferase activity in the brains of patients with Alzheimer's disease.

1 reference

12 December 2020

Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids.

1 reference

12 December 2020

Effect of oral N-acetylcysteine on mucus clearance

1 reference

12 December 2020

Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione.

1 reference

12 December 2020

Glutathione: interorgan translocation, turnover, and metabolism

1 reference

12 December 2020

Free and protein-bound glutathione in normal and cataractous human lenses

1 reference

12 December 2020

Lipid peroxide formation in the brain of aging rats.

1 reference

12 December 2020

Glutathione-degrading enzymes of microvillus membranes

1 reference

12 December 2020

1 reference

12 December 2020

Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts

1 reference

12 December 2020

Transport of glutathione, as gamma-glutamylcysteinylglycyl ester, into liver and kidney

1 reference

12 December 2020

Possible influence of glutathione on postischemic liver injury.

1 reference

12 December 2020

2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity

1 reference

12 December 2020

The level and half-life of glutathione in human plasma

1 reference

12 December 2020

In vivo cleavability of a disulfide-based chimeric opioid peptide in rat brain.

1 reference

12 December 2020

Glutathione protects against hypoxic/hypoglycemic decreases in 2-deoxyglucose uptake and presynaptic spikes in hippocampal slices

1 reference

12 December 2020

Oxidative damage to DNA in patients with cystic fibrosis

1 reference

12 December 2020

Comparison of the delivery of reduced glutathione into P388D1 cells by reduced glutathione and its mono- and diethyl ester derivatives

1 reference

12 December 2020

gamma-Glutamylcysteine ethyl ester for myocardial protection in dogs during ischemia and reperfusion

1 reference

12 December 2020

Protective effects of glycine and esterified gamma-glutamylcysteine on ischemia/reoxygenation injury of rat liver

1 reference

12 December 2020

Effect of YM737, a new glutathione analogue, on ischemic brain edema

1 reference

12 December 2020

Glutathione mercaptides as transport forms of metals

1 reference

12 December 2020

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

1 reference

12 December 2020

Systemic deficiency of glutathione in cystic fibrosis

1 reference

12 December 2020

Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process

1 reference

12 December 2020

1 reference

12 December 2020

Transport of glutathione diethyl ester into human cells

1 reference

12 December 2020

Glutathione in health and disease: pharmacotherapeutic issues

1 reference

12 December 2020

Pulmonary dysfunction in cystic fibrosis is associated with oxidative stress

1 reference

12 December 2020

Conversion of gamma-glutamylcysteinylethyl ester to glutathione in rat hepatocytes

1 reference

12 December 2020

Effect of buthionine sulfoximine, a synthesis inhibitor of the antioxidant glutathione, on the murine nigrostriatal neurons

1 reference

12 December 2020

Glutathione and cysteine in HIV-infected hemophiliacs

1 reference

12 December 2020

Glutathione and glutathione delivery compounds

1 reference

12 December 2020

Glutathione protects astrocytes from peroxynitrite-mediated mitochondrial damage: implications for neuronal/astrocytic trafficking and neurodegeneration

1 reference

12 December 2020

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide.

1 reference

12 December 2020

Oxidants and antioxidants in viral diseases: disease mechanisms and metabolic regulation.

1 reference

12 December 2020

Lipopolysaccharide-mediated hepatic glutathione depletion and progressive mitochondrial damage in mice: protective effect of glutathione monoethyl ester

1 reference

12 December 2020

The influence of antioxidant nutrients on viral infection.

1 reference

12 December 2020

Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death

1 reference

12 December 2020

Clinical applications of N-acetylcysteine.

1 reference

12 December 2020

Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes

1 reference

12 December 2020

Oxidative mechanisms in nigral cell death in Parkinson's disease.

1 reference

12 December 2020

Preventive effect of gamma-glutamylcysteinylethyl ester on carbon tetrachloride-induced hepatic triglyceride accumulation in mice

1 reference

12 December 2020

Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases.

1 reference

12 December 2020

Glutathione: an overview of biosynthesis and modulation

1 reference

12 December 2020

Glutathione permeability of CFTR.

1 reference

12 December 2020

Protection of cultured gastric cells against tert-butyl hydroperoxide by glutathione isopropyl ester

1 reference

12 December 2020

Endogenous glutathione conjugates: occurrence and biological functions

1 reference

12 December 2020

Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species.

1 reference

12 December 2020

Glutathione therapy: from prodrugs to genes

1 reference

12 December 2020

10.3390/MOLECULES15031242

Identifiers

DOI

1 reference

1 July 2019

PMC publication ID

6257297

1 reference

1 July 2019

PubMed publication ID

20335977

1 reference

1 July 2019