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Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions.
scientific article published on May 2014
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scholarly article
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Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
title
Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
main subject
metformin
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inferred from title
author
Petr Pávek
series ordinal
5
1 reference
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Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
Jukka Hakkola
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Jukka Hakkola
series ordinal
6
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Sanna-Mari Aatsinki
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1
1 reference
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Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
Marcin Buler
series ordinal
2
1 reference
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Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
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5 March 2020
Henriikka Salomäki
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
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5 March 2020
Markku Koulu
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
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5 March 2020
language of work or name
English
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publication date
1 May 2014
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Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
published in
British Journal of Pharmacology
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Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
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5 March 2020
volume
171
1 reference
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Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
issue
9
1 reference
stated in
Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
page(s)
2351-2363
1 reference
stated in
Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
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Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood
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PubMed Central
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Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism
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SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD.
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The biology of PGC-1α and its therapeutic potential
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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
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Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase-Dependent Regulation of the Orphan Nuclear Receptor SHP
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Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo
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An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle
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Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
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CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
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23 August 2017
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6 September 2017
AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.
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14 September 2017
Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4.
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14 September 2017
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
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14 September 2017
Inhibition of phosphoenolpyruvate carboxykinase gene expression by metformin in cultured hepatocytes
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23 June 2018
Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase
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23 June 2018
Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver
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1 September 2018
Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3997275
retrieved
1 September 2018
Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.
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1 September 2018
Hepatocyte nuclear factor-4alpha regulates the human apolipoprotein AV gene: identification of a novel response element and involvement in the control by peroxisome proliferator-activated receptor-gamma coactivator-1alpha, AMP-activated protein kina
1 reference
stated in
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3997275
retrieved
1 September 2018
AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3997275
retrieved
1 September 2018
Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3997275
retrieved
1 September 2018
Role of glucose-6 phosphatase, glucokinase, and glucose-6 phosphate in liver insulin resistance and its correction by metformin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3997275
retrieved
1 September 2018
Identifiers
DOI
10.1111/BPH.12585
1 reference
stated in
Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
PMCID
3997275
1 reference
stated in
Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
PubMed ID
24428821
1 reference
stated in
Europe PubMed Central
PMCID
3997275
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24428821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
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