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L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline.
scientific article published on January 2010
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20397369
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20397369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
review article
1 reference
stated in
Europe PubMed Central
title
L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20397369
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20397369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
main subject
Alzheimer's disease
0 references
acetylcysteine
1 reference
based on heuristic
inferred from title
author name string
Andrew McCaddon
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20397369
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20397369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
Peter R Hudson
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20397369
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20397369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
publication date
1 January 2010
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20397369
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20397369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
published in
C N S Spectrums
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20397369
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20397369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
volume
15
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20397369
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20397369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
issue
1 Suppl 1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20397369
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20397369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
page(s)
2-5; discussion 6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20397369
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20397369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
cites work
Co-administration of N-acetylcysteine, vitamin B12 and folate in cognitively impaired hyperhomocysteinaemic patients
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A novel role for vitamin B(12): Cobalamins are intracellular antioxidants in vitro
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Vitamin B(12) and redox homeostasis: cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD)
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7 January 2021
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A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins
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Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration
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Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly.
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Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus.
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Is hyperhomocysteinemia due to the oxidative depletion of folate rather than to insufficient dietary intake?
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7 January 2021
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Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease
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7 January 2021
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Possible role of amyloid-beta, adenine nucleotide translocase and cyclophilin-D interaction in mitochondrial dysfunction of Alzheimer's disease
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Crossref
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https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
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Oxidative stress, mitochondrial dysfunction, and stress signaling in Alzheimer's disease
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https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
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Non-cholinergic strategies for treating and preventing Alzheimer's disease
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7 January 2021
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Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria
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7 January 2021
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Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations
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7 January 2021
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THE METHYL FOLATE TRAP A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid-induced exacerbation of subacute combined degeneration in pernicious anaemia
1 reference
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7 January 2021
based on heuristic
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Amyloid-beta aggregation
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Crossref
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https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
based on heuristic
inferred from DOI database lookup
Compensatory responses induced by oxidative stress in Alzheimer disease
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7 January 2021
based on heuristic
inferred from DOI database lookup
Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms
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https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
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inferred from DOI database lookup
Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer's disease: a 1-year, open-label pilot study with an 16-month caregiver extension
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
based on heuristic
inferred from DOI database lookup
Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment.
1 reference
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Crossref
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https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
based on heuristic
inferred from DOI database lookup
Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
based on heuristic
inferred from DOI database lookup
Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial accumulation of APP and Abeta: significance for Alzheimer disease pathogenesis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cobalamin-dependent methionine synthase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain
1 reference
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Crossref
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https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tau phosphorylation: physiological and pathological consequences
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7 January 2021
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inferred from DOI database lookup
Choline and cholinergic neurons
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic and cellular studies of oxidative stress in methylmalonic aciduria (MMA) cobalamin deficiency type C (cblC) with homocystinuria (MMACHC).
1 reference
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7 January 2021
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Oxidative damage in mild cognitive impairment and early Alzheimer's disease
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7 January 2021
based on heuristic
inferred from DOI database lookup
Homocysteine and Alzheimer's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
based on heuristic
inferred from DOI database lookup
Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
based on heuristic
inferred from DOI database lookup
Nutritional factors in physical and cognitive functions of elderly people
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High prevalence of cobalamin deficiency in elderly outpatients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phospholipid Methylation and Biological Signal Transmission
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Vitamin B12-B6-folate treatment improves blood-brain barrier function in patients with hyperhomocysteinaemia and mild cognitive impairment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Slowed synthesis of DNA and methionine is a pathogenetic mechanism common to dementia in Down's syndrome, AIDS and Alzheimer's disease?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of cognitive impairment in the elderly: homocysteine is an early marker.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The worldwide challenge of the dementias: a role for B vitamins and homocysteine?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Folate and methylation status in relation to phosphorylated tau protein(181P) and beta-amyloid(1-42) in cerebrospinal fluid.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
based on heuristic
inferred from DOI database lookup
Efficacy of a vitamin/nutriceutical formulation for moderate-stage to later-stage Alzheimer's disease: a placebo-controlled pilot study
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
based on heuristic
inferred from DOI database lookup
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
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7 January 2021
based on heuristic
inferred from DOI database lookup
Methylmalonic acid, a biochemical hallmark of methylmalonic acidurias but no inhibitor of mitochondrial respiratory chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alzheimer's disease: a 'cobalaminergic' hypothesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Total serum homocysteine in senile dementia of Alzheimer type
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homocysteine and cognitive impairment; a case series in a General Practice setting
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cerebrospinal fluid biomarkers for Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Absence of macrocytic anaemia in Alzheimer's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of folic acid and Vitamin B12 in genomic stability of human cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The aging of the NMDA receptor complex
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pin1 in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pin-pointing APP processing.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homocysteine and cognitive decline in healthy elderly
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Release of neuroactive substances: homocysteic acid as an endogenous agonist of the NMDA receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homocysteine and brain atrophy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cerebrospinal fluid biomarkers and prediction of conversion in patients with mild cognitive impairment: 4-year follow-up in a routine clinical setting.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homocysteine and brain atrophy on MRI of non-demented elderly
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homocysteine potentiates beta-amyloid neurotoxicity: role of oxidative stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elevated levels of homocysteine compromise blood-brain barrier integrity in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional vitamin B(12) deficiency and Alzheimer disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of Alzheimer's disease in the long-term-care setting
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homocysteine, vitamin B12 and folate in vascular dementia and in Alzheimer disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Urinary and Plasma Homocysteine and Cysteine Levels during Prolonged Oral N-Acetylcysteine Therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1017%2FS1092852900027589
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1017/S1092852900027589
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20397369
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20397369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
PubMed publication ID
20397369
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20397369
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20397369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
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