(Q37742565)

22 August 2017

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title

Nonlinear pharmacokinetics: clinical Implications (English)

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22 August 2017

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Ludden TM

1

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22 August 2017

1 June 1991

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Clinical Pharmacokinetics

22 August 2017

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22 August 2017

20

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22 August 2017

429-446

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22 August 2017

6

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https://scigraph.springernature.com/pub.10.2165/00003088-199120060-00001

22 August 2017

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Stable oral availability of sustained release propranolol when co-administered with hydralazine or food: evidence implicating substrate delivery rate as a determinant of presystemic drug interactions

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12 December 2020

Saturable pharmacokinetics in the renal excretion of drugs

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12 December 2020

Pharmacokinetic and pharmacodynamic studies with long-acting propranolol

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12 December 2020

Pharmacokinetics of Salicylate Elimination in Man

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12 December 2020

Kinetic models of induction: I. Persistence of the inducing substance

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12 December 2020

Predictability of verapamil steady-state plasma levels from single-dose data explained

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12 December 2020

Time-dependent kinetics. V: Time course of drug levels during enzyme induction (one-compartment model)

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12 December 2020

Clinical utility of a Bayesian dosing program for phenytoin.

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12 December 2020

Impaired Lignocaine metabolism in patients with myocardial infarction and cardiac failure

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12 December 2020

Nonlinear theophylline elimination

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12 December 2020

Pharmacokinetics of theophylline. Application to adjustment of the clinical dose of aminophylline.

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12 December 2020

Pharmacokinetics of ethanol: a review

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12 December 2020

Effect of saturable binding on the pharmacokinetics of drugs: a simulation

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12 December 2020

Cardiopulmonary bypass and the pharmacokinetics of drugs. An update

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12 December 2020

The influence of urinary pH on the renal excretion of salicyl derivatives during aspirin therapy

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12 December 2020

Relationship of theophylline clearance to oral dosage in children with chronic asthma

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12 December 2020

Sodium salicylamide: Relative bioavailability and subjective effects

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12 December 2020

Nomographic estimation of time to reach steady-state serum concentration during phenytoin therapy

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12 December 2020

Salicylate accumulation kinetics in man

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12 December 2020

Theoretical Michaelis-Menten elimination model for propranolol

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12 December 2020

Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism

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12 December 2020

Theophylline bioavailability following chronic dosing of an elixir and two solid dosage forms

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12 December 2020

Isolation of II-alcohol dehydrogenase of human liver: Is it a determinant of alcoholism?

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12 December 2020

Kinetic studies on rifampicin. I. Serum concentration analysis in subjects treated with different oral doses over a period of two weeks

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12 December 2020

Increased alpha-1-acid glycoprotein and lidocaine disposition in myocardial infarction.

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12 December 2020

Rate of phenytoin accumulation in man: a simulation study

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12 December 2020

In vivo determination of valproate binding constants during sole and multi-drug therapy.

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12 December 2020

Clinical applicability of current pharmacokinetic models: splanchnic elimination of 5-fluorouracil in cancer patients.

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12 December 2020

Role of concentration-dependent plasma protein binding in disopyramide disposition

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12 December 2020

Stereoselective binding of disopyramide to human plasma protein

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12 December 2020

Verapamil kinetics in normal subjects and patients with coronary artery spasm.

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12 December 2020

Factors affecting free (unbound) lignocaine concentration in suspected acute myocardial infarction

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12 December 2020

Intestinal absorption mechanism of amphoteric β-lactam antibiotics I: Comparative absorption and evidence for saturable transport of amino-β-iactam antibiotics by in situ rat small intestine

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12 December 2020

Influence of methylxanthine-containing foods on theophylline metabolism and kinetics

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12 December 2020

Phenylalanine Absorption and Metabolism in Parkinsonian Patients

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12 December 2020

Interaction between oral propranolol and hydralazine

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12 December 2020

Enzyme induction (first of three parts)

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12 December 2020

Pharmacokinetics of rifampin in children. I. Multiple dose intravenous infusion

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12 December 2020

Autoinduction of carbamazepine metabolism in children examined by a stable isotope technique

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12 December 2020

Pharmacokinetics of a single evening dose of slow release theophylline in patients with chronic lung disease

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12 December 2020

Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.

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12 December 2020

Characterization of aminocephalosporin transport across rat small intestine

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12 December 2020

Pharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administration

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12 December 2020

Diets affecting treatment of parkinsonism with levodopa

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12 December 2020

Pharmacokinetics of salicylamide elimination in man

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12 December 2020

Oral cyclacillin interacts with the absorption of oral ampicillin, amoxycillin, and bacampicillin.

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12 December 2020

Disposition of phenytoin in critically ill trauma patients

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12 December 2020

Perioperative variability of binding of lidocaine, quinidine, and propranolol after cardiac operations.

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12 December 2020

Saturable rate of cefatrizine absorption after oral administration to humans

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12 December 2020

Phenylalanine and tyrosine metabolism in Parkinson's disease treated with levodopa

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12 December 2020

Salicylate clearance, the resultant of protein binding and metabolism

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12 December 2020

Disopyramide pharmacokinetics and bioavailability following the simultaneous administration of disopyramide and 14C-disopyramide

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12 December 2020

Pharmacokinetics of the antiarrhythmic disopyramide in healthy humans

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12 December 2020

The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo

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12 December 2020

Clinical significance of pharmacokinetic models of hepatic elimination

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12 December 2020

Pharmacokinetics of carbamazepine in normal humans after single and repeated oral doses

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12 December 2020

Dose-dependent elimination of propranolol and its major metabolites in humans

1 reference

12 December 2020

Valproic acid dosage and plasma protein binding and clearance

1 reference

12 December 2020

Steady-state pharmacokinetics of phenytoin from routinely collected patient data

1 reference

12 December 2020

The bioavailability of ultramicrosize griseofulvin (Gris-PEG) tablets in man

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12 December 2020

Salicylate metabolism in twins. Evidence suggesting a genetic influence and induction of salicylurate formation

1 reference

12 December 2020

Predicting individual phenytoin dosage

1 reference

12 December 2020

Phenytoin cumulation profiles

1 reference

12 December 2020

Dose-dependent pharmacokinetics with single daily dose slow release theophylline in patients with chronic lung disease

1 reference

12 December 2020

Dose-dependent kinetics for theophylline: observations among ambulatory asthmatic children

1 reference

12 December 2020

Prediction of steady-state verapamil plasma concentrations in children and adults.

1 reference

12 December 2020

Ascorbic acid absorption in man: influence of divided dose and food

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12 December 2020

Concentration-dependence of disopyramide binding to plasma protein and its influence on kinetics and dynamics

1 reference

12 December 2020

Interaction of disopyramide enantiomers for sites on plasma protein

1 reference

12 December 2020

Stereoselective pharmacokinetics of disopyramide enantiomers in man

1 reference

12 December 2020

Factors affecting the absorption of riboflavin in man.

1 reference

12 December 2020

The auto-induction of carbamazepine during long-term therapy.

1 reference

12 December 2020

The EMIT FreeLevel ultrafiltration technique compared with equilibrium dialysis and ultracentrifugation to determine protein binding of phenytoin

1 reference

12 December 2020

Multicompartmental analysis of serum, urine and bile concentrations of rifampicin and desacetyl-rifampicin in subjects treated for one week

1 reference

12 December 2020

Effect of dose on phenytoin absorption

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12 December 2020

In vivo interaction of the enantiomers of disopyramide in human subjects

1 reference

12 December 2020

First-pass elimination. Basic concepts and clinical consequences

1 reference

12 December 2020

Pharmacokinetic concepts - drug binding, apparent volume of distribution and clearance

1 reference

12 December 2020

Relative bioavailability of immediate- and sustained-release hydralazine formulations.

1 reference

12 December 2020

Time course of carbamazepine self-induction

1 reference

12 December 2020

Influence of long-term infusions on lidocaine kinetics.

1 reference

12 December 2020

Pharmacokinetic Model to Describe Self‐Induced Decreases in Steady‐State Concentrations of Carbamazepine

1 reference

12 December 2020

Quantitative pooling of Michaelis-Menten equations in models with parallel metabolite formation paths.

1 reference

12 December 2020

Propranolol: pooled Michaelis-Menten parameters and the effect of input rate on bioavailability.

1 reference

12 December 2020

Phenytoin Michaelis-Menten pharmacokinetics in Caucasian paediatric patients

1 reference

12 December 2020

Nonlinear pharmacokinetics of unbound propranolol after oral administration

1 reference

12 December 2020

On the role of alpha 1-acid glycoprotein in lignocaine accumulation following myocardial infarction

1 reference

12 December 2020

Antiarrhythmic activity and unbound concentrations of disopyramide enantiomers in patients

1 reference

12 December 2020

Theoretical decrease in systemic availability with decrease in input rate at steady-state for first-pass drugs

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12 December 2020

Hydralazine elimination in man

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12 December 2020

Food, splanchnic blood flow, and bioavailability of drugs subject to first-pass metabolism

1 reference

12 December 2020

Lignocaine and indocyanine green kinetics in patients following myocardial infarction

1 reference

12 December 2020

Paracetamol Overdosage Pharmacological Considerations and Clinical Management

1 reference

12 December 2020

Saturable binding of cyclosporin A to erythrocytes: estimation of binding parameters in renal transplant patients and implications for bioavailability assessment

1 reference

12 December 2020

Evaluation of the effect of nonlinear kinetics on dosage adjustments of theophylline

1 reference

12 December 2020

Intestinal blood flow and absorption of non-dissociable substances

1 reference

12 December 2020

Steady-state nonlinear pharmacokinetics of 5-fluorouracil during hepatic arterial and intravenous infusions in cancer patients.

1 reference

12 December 2020

Dose-dependent pharmacokinetic behavior of lidocaine in the conscious dog.

1 reference

12 December 2020

Induction of salicyluric acid formation in rheumatoid arthritis patients treated with salicylates

1 reference

12 December 2020

Bioavailability of sustained release propranolol formulations

1 reference

12 December 2020

Theophylline toxicity in term infants

1 reference

12 December 2020

Characterization of the oral absorption of beta-lactam antibiotics. I. Cephalosporins: determination of intrinsic membrane absorption parameters in the rat intestine in situ.

1 reference

12 December 2020

Formal kinetics of water and solute absorption with regard to intestinal blood flow

1 reference

12 December 2020

Ascorbic acid absorption in man--pharmacokinetic implications

1 reference

12 December 2020

Stereoselective effects of disopyramide enantiomers in humans

1 reference

12 December 2020

Blood ethanol concentrations during and following constant‐rate intravenous infusion of alcohol

1 reference

12 December 2020

Increased Plasma Protein Binding of Propranolol and Chlorpromazine Mediated by Disease-Induced Elevations of Plasma α1Acid Glycoprotein

1 reference

12 December 2020

Evaluation of a proposed method for phenytoin maintenance dose prediction following an intravenous loading dose

1 reference

12 December 2020

Pharmacokinetics of lidocaine after prolonged intravenous infusions in uncomplicated myocardial infarction.

1 reference

12 December 2020

Evaluation of a Bayesian regression-analysis computer program using non-steady-state phenytoin concentrations.

1 reference

12 December 2020

Variable free and total valproic acid concentrations in sole- and multi-drug therapy

1 reference

12 December 2020

Effect of Altered Plasma Protein Binding on Apparent Volume of Distribution

1 reference

12 December 2020

1 reference

12 December 2020

STUDIES ON THE COUMARIN ANTICOAGULANT DRUGS: A COMPARISON OF THE PHARMACODYNAMICS OF DICUMAROL AND WARFARIN IN MAN

1 reference

12 December 2020

Dependence of renal clearance on urine flow: a mathematical model and its application.

1 reference

12 December 2020

Valproic acid clearance: unbound fraction and diurnal variation in young and elderly adults

1 reference

12 December 2020

Michaelis-Menten absorption kinetics in drugs: - examples and implications

1 reference

12 December 2020

Phenytoin dose adjustment in epileptic patients

1 reference

12 December 2020

Apparent volumes of distribution and drug binding to plasma proteins and tissues

1 reference

12 December 2020

Phenytoin pharmacokinetics in critically ill trauma patients

1 reference

12 December 2020

Reduction in lidocaine clearance during continuous infusion and by coadministration of propranolol.

1 reference

12 December 2020

Reduced verapamil clearance during long-term oral administration

1 reference

12 December 2020

Valproic acid free fraction in epileptic children under chronic monotherapy

1 reference

12 December 2020

Determinants of systemic availability of oral hydralazine in heart failure

1 reference

12 December 2020

Bayesian regression analysis of non-steady-state phenytoin concentrations: evaluation of predictive performance.

1 reference

12 December 2020

Pharmacokinetics of ethanol after oral administration in the fasting state

1 reference

12 December 2020

Metabolism of salicylate during chronic aspirin therapy

1 reference

12 December 2020

FACTORS AFFECTING ACETYLATION IN-VIVO OF PARA-AMINOBENZOIC ACID BY HUMAN SUBJECTS

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12 December 2020

Lidocaine plasma protein binding.

1 reference

12 December 2020

Relationship between alpha 1-acid glycoprotein and lidocaine disposition in myocardial infarction.

1 reference

12 December 2020

Drug Metabolism by the Gastrointestinal Mucosa

1 reference

12 December 2020

Time to reach steady state and prediction of steady-state concentrations for drugs obeying Michaelis-Menten elimination kinetics

1 reference

12 December 2020

The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide

1 reference

12 December 2020

Effect of oral dose size on hydralazine kinetics and vasodepressor response.

1 reference

12 December 2020

Effect of the duration of infusion on the disposition of lidocaine in dogs

1 reference

12 December 2020

10.2165/00003088-199120060-00001

Identifiers

DOI

1 reference

PubMed ID

2044328

Dimensions Publication ID

22 August 2017

0 references

1 reference

PubMed ID

2044328