(Q37745668)

22 August 2017

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title

Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: a pathogenetically based approach (English)

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22 August 2017

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2

Charlotte E Teunissen

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22 August 2017

6

Henk W Berendse

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22 August 2017

3

Benjamin Drukarch

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22 August 2017

4

Connie R Jimenez

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22 August 2017

Karin D van Dijk

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PubMed ID

20451609

22 August 2017

Henk J Groenewegen

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5

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PubMed ID

20451609

22 August 2017

Wilma D J van de Berg

series ordinal

7

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22 August 2017

6 May 2010

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22 August 2017

Neurobiology of Disease

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22 August 2017

39

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22 August 2017

3

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22 August 2017

229-241

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Oxygen toxicity protecting enzymes in Parkinson's disease. Increase of superoxide dismutase-like activity in the substantia nigra and basal nucleus

22 August 2017

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12 December 2020

Biomarker discovery in neurodegenerative diseases: a proteomic approach.

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12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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12 December 2020

Cerebrospinal fluid biomarkers in Parkinson's disease with dementia and dementia with Lewy bodies.

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12 December 2020

The ubiquitin pathway in Parkinson's disease.

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12 December 2020

Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies

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12 December 2020

Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds

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12 December 2020

Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

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12 December 2020

The potential use of a dopamine neuron antibody and a striatal-derived neurotrophic factor as diagnostic markers in Parkinson's disease

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12 December 2020

Cerebrospinal fluid levels of angiotensin-converting enzyme, acetylcholinesterase, and dopamine metabolites in dementia associated with Alzheimer's disease and Parkinson's disease: a correlative study.

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12 December 2020

Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging

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12 December 2020

Increased cerebrospinal fluid levels of neurofilament protein in progressive supranuclear palsy and multiple-system atrophy compared with Parkinson's disease

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12 December 2020

Flow rate of cerebrospinal fluid (CSF)--a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases.

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12 December 2020

Normal cerebrospinal fluid glutathione concentrations in Parkinson's disease, Alzheimer's disease and multiple system atrophy.

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12 December 2020

Diazepam binding inhibitor in brain and in cerebrospinal fluid of human

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12 December 2020

Blood-based neurochemical diagnosis of vascular dementia: a pilot study.

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12 December 2020

8-OHdG in cerebrospinal fluid as a marker of oxidative stress in various neurodegenerative diseases.

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12 December 2020

Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease

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12 December 2020

Humoral response to hsp 65 in multiple sclerosis and other neurologic conditions

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12 December 2020

The soluble form of Fas molecule is elevated in parkinsonian brain tissues.

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12 December 2020

Changed transferrin sialylation in Parkinson's disease

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12 December 2020

alpha-Synuclein locus triplication causes Parkinson's disease

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12 December 2020

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

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12 December 2020

Cortical Lewy bodies and Alzheimer-type changes in patients with Parkinson's disease.

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12 December 2020

Characterization of the AD7C-NTP cDNA expression in Alzheimer's disease and measurement of a 41-kD protein in cerebrospinal fluid

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12 December 2020

Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease

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12 December 2020

Reduced cholecystokinin levels in cerebrospinal fluid of parkinsonian and schizophrenic patients. Effect of ceruletide in schizophrenia

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12 December 2020

Cerebrospinal fluid arginine vasopressin in Parkinson's disease, dementia, and other degenerative disorders

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12 December 2020

Viral Antibodies in Serum and CSF of Parkinsonian Patients and Controls

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12 December 2020

No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases

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12 December 2020

Decreased CSF-beta-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of beta-amyloid induced by disparate mechanisms.

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12 December 2020

A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking.

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12 December 2020

CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging

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12 December 2020

Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

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12 December 2020

Biomarkers for Parkinson's disease

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12 December 2020

Cytokines in Parkinson's disease

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12 December 2020

Cerebrospinal fluid antibodies to coronavirus in patients with Parkinson's disease

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12 December 2020

Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients.

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12 December 2020

Therapy of Parkinsonian syndrome using L-dopa. Current state and problems

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12 December 2020

Neurotrophins and cytokines in Parkinson's disease.

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12 December 2020

Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease

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12 December 2020

Tau protein concentrations in cerebrospinal fluid of non-demented Parkinson's disease patients.

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12 December 2020

Immunoreactivities of amyloid beta peptide((1-42)) and total tau protein in lumbar cerebrospinal fluid of patients with normal pressure hydrocephalus.

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12 December 2020

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

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12 December 2020

Decreased ferritin levels in brain in Parkinson's disease

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12 December 2020

Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation

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12 December 2020

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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12 December 2020

Normal levels of clusterin in cerebrospinal fluid in Alzheimer's disease, and no change after acute ischemic stroke.

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12 December 2020

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

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12 December 2020

CSF somatostatin-like immunoreactivity in dementia of Parkinson's disease

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12 December 2020

Glucocerebrosidase mutations in subjects with parkinsonism

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12 December 2020

Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy).

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12 December 2020

CSF somatostatin is elevated in patients with postzoster neuralgia

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12 December 2020

Differential DJ-1 gene expression in Parkinson's disease.

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12 December 2020

Diazepam binding inhibitor-like immunoreactivity (DBI-LI) in human CSF. Correlations with neurological disorders

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12 December 2020

Acetyl- and butyrylcholinesterase activity in the cerebrospinal fluid of patients with Parkinson's disease.

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12 December 2020

Central role of alpha-synuclein oligomers in neurodegeneration in Parkinson disease

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12 December 2020

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

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12 December 2020

Decreased concentration of annexin V in parkinsonian cerebrospinal fluid: speculation on the underlying cause

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12 December 2020

Consecutive analyses of cerebrospinal fluid axonal and glial markers in Parkinson's disease and atypical Parkinsonian disorders

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12 December 2020

Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders.

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12 December 2020

DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease

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12 December 2020

Multiple system atrophy: a primary oligodendrogliopathy.

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12 December 2020

Brain beta 2-microglobulin levels are elevated in the striatum in Parkinson's disease

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12 December 2020

Integrity of the blood-cerebrospinal fluid barrier in early Parkinson's disease.

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12 December 2020

Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies

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12 December 2020

Substance P in human cerebrospinal fluid: Reductions in peripheral neuropathy and autonomic dysfunction

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12 December 2020

Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy.

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12 December 2020

Complement protein isoforms in CSF as possible biomarkers for neurodegenerative disease

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12 December 2020

Cerebrospinal fluid Abeta42 is reduced in multiple system atrophy but normal in Parkinson's disease and progressive supranuclear palsy

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12 December 2020

Alpha 1-antichymotrypsin and IL-1 beta are not increased in CSF or serum in Alzheimer's disease.

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12 December 2020

Reduced ferroxidase activity in the cerebrospinal fluid from patients with Parkinson's disease

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12 December 2020

Pattern of Tau forms in CSF is altered in progressive supranuclear palsy.

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12 December 2020

The diagnosis of Parkinson's disease

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12 December 2020

Protein analysis in human cerebrospinal fluid: Physiological aspects, current progress and future challenges.

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12 December 2020

The diagnostic value of cerebrospinal fluid tau protein in dementing and nondementing neuropsychiatric disorders.

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12 December 2020

Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases.

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12 December 2020

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

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12 December 2020

Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia.

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12 December 2020

Neurochemical markers in the cerebrospinal fluid of patients with Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and normal controls

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12 December 2020

Proteome analysis of human substantia nigra in Parkinson's disease

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12 December 2020

Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases

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12 December 2020

Increased concentration of C4d complement protein in the cerebrospinal fluids in progressive supranuclear palsy.

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12 December 2020

Cerebrospinal fluid GABA and homocarnosine concentrations in patients with Friedreich's ataxia, Parkinson's disease, and Huntington's chorea

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12 December 2020

Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients.

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12 December 2020

Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases

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12 December 2020

Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2'-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurod

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12 December 2020

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12 December 2020

Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders

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12 December 2020

Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of amyotrophic lateral sclerosis patients

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12 December 2020

Acetylcholinesterase and butyrylcholinesterase activity in the cerebrospinal fluid of patients with neurodegenerative diseases involving cholinergic systems

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12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

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12 December 2020

Cerebrospinal fluid corticotropin-releasing hormone in neurodegenerative diseases: reduction in spinocerebellar degeneration.

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12 December 2020

Cerebrospinal fluid norepinephrine, 3-methoxy-4-hydroxyphenylglycol and neuropeptide Y levels in Parkinson's disease, multiple system atrophy and dementia of the Alzheimer type.

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12 December 2020

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12 December 2020

Parkinson's disease and dementia: clinical and neurochemical correlations

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12 December 2020

Epitopes located in spatially separate domains of each neurofilament subunit are present in parkinson's disease lewy bodies

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12 December 2020

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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12 December 2020

Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options.

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12 December 2020

Prevalence of anti-locus coeruleus immunoreactivity in CSF of patients with autonomic failure.

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12 December 2020

Association between early-onset Parkinson's disease and mutations in the parkin gene

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12 December 2020

Progression of Parkinson's disease in the clinical phase: potential markers

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12 December 2020

Proteomic analysis of the cerebrospinal fluid of Parkinson's disease patients.

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12 December 2020

Apolipoprotein E genotyping and cerebrospinal fluid tau protein: implications for the clinical diagnosis of Alzheimer's disease

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12 December 2020

Humoral response to hsp 65 and hsp 70 in cerebrospinal fluid in Parkinson's disease

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12 December 2020

Plasma alpha-synuclein is decreased in subjects with Parkinson's disease.

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12 December 2020

Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases

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12 December 2020

Virus antibodies in Parkinson's disease. Herpes simplex and measles virus antibodies in serum and CSF and their relation to HLA types

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12 December 2020

Cerebrospinal fluid arginine vasopressin in degenerative disorders and other neurological diseases

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12 December 2020

Analysis and quantitation of the beta-amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients with a monoclonal antibody-based immunoassay

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12 December 2020

Neurokinin concentrations in cerebrospinal fluid. A preliminary study in Parkinson's disease

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12 December 2020

Cerebrospinal fluid choline levels are decreased in Parkinson's disease.

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12 December 2020

Correlation between DJ-1 levels in the cerebrospinal fluid and the progression of disabilities in multiple sclerosis patients

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12 December 2020

Increased angiotensin-converting enzyme activity in cerebrospinal fluid of treated patients with Parkinson's disease

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12 December 2020

Abnormal levels of prohibitin and ATP synthase in the substantia nigra and frontal cortex in Parkinson's disease.

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12 December 2020

The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service

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12 December 2020

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

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12 December 2020

Tissue transglutaminase catalyzes the formation of alpha-synuclein crosslinks in Parkinson's disease

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12 December 2020

Cerebrospinal tau, phospho-tau, and beta-amyloid and neuropsychological functions in Parkinson's disease.

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12 December 2020

Cerebrospinal fluid levels of angiotensin-converting enzyme in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy.

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12 December 2020

CSF neurofilament light chain and tau differentiate multiple system atrophy from Parkinson's disease

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12 December 2020

Increased levels of neuronal thread protein in cerebrospinal fluid of patients with Alzheimer's disease

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12 December 2020

Muscarinic receptor stimulation induces translocation of an alpha-synuclein oligomer from plasma membrane to a light vesicle fraction in cytoplasm

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12 December 2020

Somatostatin-like immunoreactivity, its molecular forms and monoaminergic metabolites in aged and demented patients with Parkinson's disease--effect of L-Dopa

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12 December 2020

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

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12 December 2020

Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases.

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12 December 2020

bcl-2 protein is increased in the brain from parkinsonian patients

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12 December 2020

Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients

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12 December 2020

Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model.

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12 December 2020

Cerebrospinal-fluid tau protein and aspartate aminotransferase in Parkinson's disease.

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12 December 2020

Proteomic identification of novel proteins associated with Lewy bodies

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12 December 2020

Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.

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12 December 2020

Apoptosis in the nervous system

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12 December 2020

Beta-Amlyoid 1–42 and Tau-Protein in Cerebrospinal Fluid of Patients with Parkinson’s Disease Dementia

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12 December 2020

CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases

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12 December 2020

Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson's disease.

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12 December 2020

CSF cyclic nucleotides and somatostatin in Parkinson's disease

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12 December 2020

Cerebrospinal fluid Abeta42 levels in multiple system atrophy.

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12 December 2020

Ceruloplasmin is increased in cerebrospinal fluid in Alzheimer's disease but not Parkinson's disease.

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12 December 2020

Concentration of neural thread protein in cerebrospinal fluid from progressive supranuclear palsy and Parkinson's disease.

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12 December 2020

Etiology of Parkinson's disease

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12 December 2020

Ubiquitin-proteasome system and Parkinson's diseases

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12 December 2020

Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?

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12 December 2020

Tau forms in CSF as a reliable biomarker for progressive supranuclear palsy.

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12 December 2020

Histochemical detection of apoptosis in Parkinson's disease.

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12 December 2020

Proteomics identification of proteins in human cortex using multidimensional separations and MALDI tandem mass spectrometer.

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12 December 2020

Both total and phosphorylated tau are increased in Alzheimer's disease

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12 December 2020

beta-Endorphin-like immunoreactivity in cerebrospinal fluid of patients with Alzheimer's disease and Parkinson's disease.

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12 December 2020

CSF acetylcholinesterase in Parkinson disease: decreased enzyme activity and immunoreactivity in demented patients

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12 December 2020

Herpesviruses and parkinsonism. Herpes simplex virus types 1 and 2, and cytomegalovirus antibodies in serum and CSF.

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12 December 2020

Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis. Short communication

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12 December 2020

Significant decreases of ulinastatin-like immunoreactive substance in the cerebrospinal fluid of patients with dementia

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12 December 2020

Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's disease.

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12 December 2020

Cerebrospinal fluid ferritin levels of patients with Parkinson's disease, Alzheimer's disease, and multiple system atrophy.

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12 December 2020

Ferritin in the cerebrospinal fluid of patients with Parkinson's disease

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12 December 2020

Somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with Parkinson's disease and its relation to dementia

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12 December 2020

Brain-derived neurotrophic factor concentrations in the cerebrospinal fluid of patients with Parkinson's disease.

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12 December 2020

Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.

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12 December 2020

Tau protein in cerebrospinal fluid: a biochemical marker for axonal degeneration in Alzheimer disease?

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12 December 2020

Expression of MMP-2, MMP-9, and MMP-1 and their endogenous counterregulators TIMP-1 and TIMP-2 in postmortem brain tissue of Parkinson's disease.

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12 December 2020

Effects of cerebrospinal fluid from patients with Parkinson disease on dopaminergic cells.

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12 December 2020

Combined assessment of tau and neuronal thread protein in Alzheimer's disease CSF

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12 December 2020

Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

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12 December 2020

Measurement of lumbar CSF levels of met-enkephalin, encrypted met-enkephalin, and neuropeptide Y in normal patients and in patients with Parkinson's disease before and after autologous transplantation of adrenal medulla into the caudate nucleus.

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12 December 2020

Beta 2-microglobulin decrease in cerebrospinal fluid from parkinsonian patients

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12 December 2020

CSF somatostatin increase in patients with early parkinsonian syndrome.

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12 December 2020

Biomarkers and Parkinson's disease

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12 December 2020

Expression of insulin-like growth factor-1 and insulin-like growth factor binding proteins in the serum and cerebrospinal fluid of patients with Parkinson's disease.

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12 December 2020

Opioid peptides in Parkinson's disease: effects of dopamine repletion

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12 December 2020

Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease.

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12 December 2020

Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra.

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12 December 2020

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12 December 2020

Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease.

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12 December 2020

Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation

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12 December 2020

Interleukin-1beta is increased in the cerebrospinal fluid of patients with small infarcts

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12 December 2020

Decreased CSF amyloid beta42 and normal tau levels in dementia with Lewy bodies

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12 December 2020

Elevated concentration of cerebrospinal fluid tissue transglutaminase in Parkinson's disease indicating apoptosis

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12 December 2020

Concentrations of amyloid beta protein in cerebrospinal fluid of patients with Alzheimer's disease.

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12 December 2020

Superoxide dismutase activity in cerebrospinal fluid of patients with dementia and some other neurological disorders.

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12 December 2020

beta-Endorphin cerebrospinal fluid decrease in untreated parkinsonian patients

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12 December 2020

Pathology of the inferior olivary nucleus in patients with multiple system atrophy.

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12 December 2020

Neurofilament heavy-chain NfHSMI35 in cerebrospinal fluid supports the differential diagnosis of Parkinsonian syndromes

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12 December 2020

Soluble oligomers for the diagnosis of neurodegenerative diseases

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12 December 2020

Antibodies Against Arboviruses in Postencephalitic and Idiopathic Parkinson's Disease

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12 December 2020

Inflammation and the degenerative diseases of aging

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12 December 2020

Reduced cholecystokinin immunoreactivity in the cerebrospinal fluid of patients with psychiatric disorders.

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12 December 2020

Identification of differentially displayed proteins in cerebrospinal fluid of Parkinson's disease patients: a proteomic approach

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12 December 2020

Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease.

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12 December 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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12 December 2020

10.1016/J.NBD.2010.04.020

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20451609