(Q37748935)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459683%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

review article

3 references

8 February 2021

28 November 2023

Proton pump inhibitors as anti vacuolar-ATPases drugs: a novel anticancer strategy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459683%20AND%20SRC:MED&resulttype=core&format=json

regulation of gene expression

2 February 2020

main subject

1 reference

8 September 2019

1 reference

15 December 2019

proton-pump inhibitors

1 reference

30 January 2021

1 reference

14 September 2020

1 reference

8 February 2021

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459683%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

author name string

Enrico P Spugnini

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459683%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Gennaro Citro

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459683%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

publication date

8 May 2010

12 references

3 April 2019

8 September 2019

28 September 2019

2 October 2019

28 November 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459683%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

3 September 2020

14 September 2020

30 January 2021

8 February 2021

28 November 2023

Journal of Experimental & Clinical Cancer Research

6 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459683%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

3 September 2020

14 September 2020

30 January 2021

8 February 2021

28 November 2023

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459683%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

page(s)

44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459683%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 2.0 Generic

2 February 2020

copyright license

11 references

3 April 2019

8 September 2019

28 September 2019

2 October 2019

28 November 2019

15 December 2019

3 September 2020

14 September 2020

30 January 2021

8 February 2021

on focus list of Wikimedia project

28 November 2023

copyright status

copyrighted

0 references

ScienceSource

0 references

exact match

https://scigraph.springernature.com/pub.10.1186/1756-9966-29-44

0 references

cites work

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1 reference

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Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells

22 August 2017

1 reference

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Bicarbonate increases tumor pH and inhibits spontaneous metastases

22 August 2017

1 reference

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Structure and regulation of the vacuolar ATPases

22 August 2017

1 reference

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Function, structure and regulation of the vacuolar (H+)-ATPases

22 August 2017

1 reference

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Targeting vacuolar H+-ATPases as a new strategy against cancer

22 August 2017

1 reference

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Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

22 August 2017

1 reference

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The E and G subunits of the yeast V-ATPase interact tightly and are both present at more than one copy per V1 complex

22 August 2017

1 reference

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Tissue pH measurement by magnetic resonance spectroscopy and imaging.

22 August 2017

1 reference

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The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

22 August 2017

1 reference

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Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells.

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Why do cancers have high aerobic glycolysis?

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents.

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

The vacuolar (H+)-ATPases--nature's most versatile proton pumps

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Modelling tumour acidity and invasion

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

The amino-terminal domain of the vacuolar proton-translocating ATPase a subunit controls targeting and in vivo dissociation, and the carboxyl-terminal domain affects coupling of proton transport and ATP hydrolysis.

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Enhancement of chemotherapy by manipulation of tumour pH.

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

The vacuolar H+-ATPase of clathrin-coated vesicles is reversibly inhibited by S-nitrosoglutathione

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Ultrastructural changes related to multidrug resistance in CEM cells: role of cytoplasmic vesicles in drug exclusion

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

The vacuolar H+-ATPase: a universal proton pump of eukaryotes

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Intracellular pH and the control of multidrug resistance

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Cell biological mechanisms of multidrug resistance in tumors

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy

22 August 2017

1 reference

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Differential glycosylation and cell surface expression of lysosomal membrane glycoproteins in sublines of a human colon cancer exhibiting distinct metastatic potentials

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

The effect of extracellular pH on matrix turnover by cells of the bovine nucleus pulposus

22 August 2017

1 reference

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pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Tumor metabolism: cancer cells give and take lactate

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Neoplastic transformation and induction of H+,K+ -adenosine triphosphatase by N-methyl-N'-nitro-N-nitrosoguanidine in the gastric epithelial RGM-1 cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Extracellular acidification alters lysosomal trafficking in human breast cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Low pH enhances Sp1 DNA binding activity and interaction with TBP.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Acidic pH enhances the invasive behavior of human melanoma cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

The effect of lysosomotropic agents and secretory inhibitors on anthracycline retention and activity in multiple drug-resistant cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Cysteine 254 of the 73-kDa A subunit is responsible for inhibition of the coated vesicle (H+)-ATPase upon modification by sulfhydryl reagents

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

A novel mechanism for regulation of vacuolar acidification

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

ABC transporters in cancer: more than just drug efflux pumps.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Activation of lysosomal function during dendritic cell maturation

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Subunit interactions in the clathrin-coated vesicle vacuolar (H(+))-ATPase complex.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876100

Topography and subunit stoichiometry of the coated vesicle proton pump

1 September 2018

1 reference

12 December 2020

Vacuolar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells

1 reference

12 December 2020

Inhibition of vacuolar H(+)-ATPase by disulfide bond formation between cysteine 254 and cysteine 532 in subunit A

1 reference

12 December 2020

Plasmalemmal pH-gradients in drug-sensitive and drug-resistant MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy

1 reference

12 December 2020

Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice

1 reference

12 December 2020

Vacuolar-type H+-ATPases at the plasma membrane regulate pH and cell migration in microvascular endothelial cells

1 reference

12 December 2020

pH and drug resistance. I. functional expression of plasmalemmal V-type H+-ATPase in drug-resistant human breast carcinoma cell lines

1 reference

12 December 2020

pH and drug resistance. II. turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs

1 reference

12 December 2020

Subunit D (Vma8p) of the yeast vacuolar H+-ATPase plays a role in coupling of proton transport and ATP hydrolysis

1 reference

12 December 2020

Elevated expression of vacuolar proton pump genes and cellular PH in cisplatin resistance

1 reference

12 December 2020

Identifiers

DOI

10.1186/1756-9966-29-44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459683%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20459683%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference