(Q37749840)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20462343%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

review article

1 reference

title

From molecular mechanisms of cardiac development to genetic substrate of congenital heart diseases (English)

1 reference

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2 February 2020

0 references

5

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2 February 2020

Giovanni Stellin

6

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2 February 2020

author name string

Antonella Cecchetto

1

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2 February 2020

Alessandra Rampazzo

2

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2 February 2020

Annalisa Angelini

3

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2 February 2020

Lucia Dal Bianco

4

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2 February 2020

Luciano Daliento

7

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2 February 2020

publication date

1 May 2010

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2 February 2020

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2 February 2020

volume

6

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2 February 2020

issue

3

1 reference

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2 February 2020

page(s)

373-393

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Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse

2 February 2020

cites work

1 reference

Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4

21 January 2018

1 reference

SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer

21 January 2018

1 reference

Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein

21 January 2018

1 reference

Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5

21 January 2018

1 reference

Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases

21 January 2018

1 reference

Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site

21 January 2018

1 reference

Heart development in Drosophila requires the segment polarity gene wingless.

21 January 2018

1 reference

The wingless signaling pathway is directly involved in Drosophila heart development

21 January 2018

1 reference

Wnt antagonism initiates cardiogenesis in Xenopus laevis

21 January 2018

1 reference

Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis

21 January 2018

1 reference

Wnt signaling in heart valve development and osteogenic gene induction

21 January 2018

1 reference

heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo

21 January 2018

1 reference

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos

21 January 2018

1 reference

tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila

21 January 2018

1 reference

Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002.

21 January 2018

1 reference

Drosophila NK-homeobox genes

21 January 2018

1 reference

Csx: a murine homeobox-containing gene specifically expressed in the developing heart

21 January 2018

1 reference

NK-2 homeobox genes and heart development

21 January 2018

1 reference

A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery

21 January 2018

1 reference

Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein.

21 January 2018

1 reference

Elevated expression of Nkx-2.5 in developing myocardial conduction cells.

21 January 2018

1 reference

The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer

21 January 2018

1 reference

Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block

21 January 2018

1 reference

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation

21 January 2018

1 reference

The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.

21 January 2018

1 reference

Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis

21 January 2018

1 reference

GATA4 transcription factor is required for ventral morphogenesis and heart tube formation

21 January 2018

1 reference

Gata5 is required for the development of the heart and endoderm in zebrafish.

21 January 2018

1 reference

GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo

21 January 2018

1 reference

An Nkx-dependent enhancer regulates cGATA-6 gene expression during early stages of heart development.

21 January 2018

1 reference

Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart.

21 January 2018

1 reference

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

21 January 2018

1 reference

A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family

21 January 2018

1 reference

D-mef2 is a target for Tinman activation during Drosophila heart development

21 January 2018

1 reference

Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development

21 January 2018

1 reference

D-mef2: a Drosophila mesoderm-specific MADS box-containing gene with a biphasic expression profile during embryogenesis

21 January 2018

1 reference

D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis

21 January 2018

1 reference

Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila

21 January 2018

1 reference

Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C

21 January 2018

1 reference

Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor

21 January 2018

1 reference

MEF2B is a potent transactivator expressed in early myogenic lineages

21 January 2018

1 reference

Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators

21 January 2018

1 reference

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

21 January 2018

1 reference

Modulation of cardiac growth and development by HOP, an unusual homeodomain protein

21 January 2018

1 reference

Hop is an unusual homeobox gene that modulates cardiac development

21 January 2018

1 reference

Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality

21 January 2018

1 reference

Serum response factor is essential for mesoderm formation during mouse embryogenesis

21 January 2018

1 reference

Srf(-/-) ES cells display non-cell-autonomous impairment in mesodermal differentiation

21 January 2018

1 reference

A HANDful of questions: the molecular biology of the heart and neural crest derivatives (HAND)-subclass of basic helix-loop-helix transcription factors

21 January 2018

1 reference

Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

21 January 2018

1 reference

Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1

21 January 2018

1 reference

The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis

21 January 2018

1 reference

The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation

21 January 2018

1 reference

The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism

21 January 2018

1 reference

The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene

21 January 2018

1 reference

21 January 2018

The T-box gene family

1 reference

Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome

21 January 2018

1 reference

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

21 January 2018

1 reference

Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation

21 January 2018

1 reference

Differential expression and function of Tbx5 and Tbx20 in cardiac development

21 January 2018

1 reference

Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2

21 January 2018

1 reference

Molecular embryology for an understanding of congenital heart diseases

21 January 2018

1 reference

The role of Zic genes in neural development.

21 January 2018

1 reference

The X-linked mouse mutation Bent tail is associated with a deletion of the Zic3 locus

21 January 2018

1 reference

The vertebrate spalt genes in development and disease

21 January 2018

1 reference

Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart

21 January 2018

1 reference

The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development

21 January 2018

1 reference

Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1.

21 January 2018

1 reference

Expression of Tfap2d, the gene encoding the transcription factor Ap-2δ, during mouse embryogenesis

21 January 2018

1 reference

Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway

21 January 2018

1 reference

Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator

21 January 2018

1 reference

Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development

21 January 2018

1 reference

Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH

21 January 2018

1 reference

Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads

21 January 2018

1 reference

Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field

21 January 2018

1 reference

Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes

21 January 2018

1 reference

A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2

21 January 2018

1 reference

FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium

21 January 2018

1 reference

Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation

21 January 2018

1 reference

Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart

21 January 2018

1 reference

Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain

21 January 2018

1 reference

Pathogenetic mechanisms of congenital cardiovascular malformations revisited

21 January 2018

1 reference

Maternal diabetes induces congenital heart defects in mice by altering the expression of genes involved in cardiovascular development

21 January 2018

1 reference

Risk factors for cardiovascular malformations in Finland

21 January 2018

1 reference

Hypertension is a major risk factor for aortic root dilatation in women with Turner's syndrome.

21 January 2018

1 reference

Chromosome 22q11.2 deletion syndrome (DiGeorge and velocardiofacial syndromes).

21 January 2018

1 reference

Role of TBX1 in human del22q11.2 syndrome

21 January 2018

1 reference

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

21 January 2018

1 reference

Mutations in the human Jagged1 gene are responsible for Alagille syndrome

21 January 2018

1 reference

Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus

21 January 2018

1 reference

Mutations in a new member of the chromodomain gene family cause CHARGE syndrome

21 January 2018

1 reference

Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis

21 January 2018

1 reference

Failure to detect an 8p22-8p23.1 duplication in patients with Kabuki (Niikawa-Kuroki) syndrome

21 January 2018

1 reference

Multifactorial inheritance hypothesis for the etiology of congenital heart diseases. The genetic-environmental interaction

21 January 2018

1 reference

The developmental genetics of congenital heart disease.

21 January 2018

1 reference

Genetics and embryological mechanisms of congenital heart diseases

21 January 2018

1 reference

Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pedia

21 January 2018

1 reference

The geneticist's role in adult congenital heart disease

21 January 2018

1 reference

Principles for the buffering of genetic variation

21 January 2018

1 reference

Genetic mechanisms controlling cardiovascular development

21 January 2018

1 reference

Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation

21 January 2018

1 reference

The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression

21 January 2018

1 reference

GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression

21 January 2018

1 reference

Mutation in myosin heavy chain 6 causes atrial septal defect

21 January 2018

1 reference

α-cardiac actin mutations produce atrial septal defects

21 January 2018

1 reference

Congenital heart disease caused by mutations in the transcription factor NKX2-5

21 January 2018

1 reference

Assignment of cardiac homeobox gene CSX to human chromosome 5q34

21 January 2018

1 reference

Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome.

21 January 2018

1 reference

Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects

21 January 2018

1 reference

NKX2.5 mutations in patients with tetralogy of fallot

21 January 2018

1 reference

Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease

21 January 2018

1 reference

Investigation of somatic NKX2-5 mutations in congenital heart disease

21 January 2018

1 reference

Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease

21 January 2018

1 reference

Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease

21 January 2018

1 reference

Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytes

21 January 2018

1 reference

Spectrum of heart disease associated with murine and human GATA4 mutation

21 January 2018

1 reference

Spectrum of atrial septal defects associated with mutations of NKX2.5 and GATA4 transcription factors

21 January 2018

1 reference

A novel mutation in the GATA4 gene in patients with Tetralogy of Fallot.

21 January 2018

1 reference

Screening of 99 Danish patients with congenital heart disease for GATA4 mutations.

21 January 2018

1 reference

GATA4 sequence variants in patients with congenital heart disease

21 January 2018

1 reference

GATA4 mutations in 486 Chinese patients with congenital heart disease.

21 January 2018

1 reference

Culture, population structure, and low genetic diversity in Pleistocene hominins

21 January 2018

1 reference

X-linked situs abnormalities result from mutations in ZIC3

21 January 2018

1 reference

X-linked transposition of the great arteries and incomplete penetrance among males with a nonsense mutation in ZIC3.

21 January 2018

1 reference

A submicroscopic deletion in Xq26 associated with familial situs ambiguus

21 January 2018

1 reference

Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects

21 January 2018

1 reference

Elucidation of penetrance variability of a ZIC3 mutation in a family with complex heart defects and functional analysis of ZIC3 mutations in the first zinc finger domain.

21 January 2018

1 reference

SALL4 mutations in Okihiro syndrome (Duane-radial ray syndrome), acro-renal-ocular syndrome, and related disorders

21 January 2018

1 reference

Okihiro syndrome is caused by SALL4 mutations

21 January 2018

1 reference

Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy

21 January 2018

1 reference

Novel mutations in the gene SALL4 provide further evidence for acro-renal-ocular and Okihiro syndromes being allelic entities, and extend the phenotypic spectrum

21 January 2018

1 reference

Identification and functional analysis of CITED2 mutations in patients with congenital heart defects

21 January 2018

1 reference

A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts

21 January 2018

1 reference

A functional genetic study identifies HAND1 mutations in septation defects of the human heart

21 January 2018

1 reference

Novel TFAP2B mutation in nonsyndromic patent ductus arteriosus

21 January 2018

1 reference

Mutational analysis of the PITX2 coding region revealed no common cause for transposition of the great arteries (dTGA)

21 January 2018

1 reference

Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot

21 January 2018

1 reference

Mutation analysis of TBX1 in non-deleted patients with features of DGS/VCFS or isolated cardiovascular defects

21 January 2018

1 reference

TBX5 mutations in non-Holt-Oram syndrome (HOS) malformed hearts

21 January 2018

1 reference

Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy

21 January 2018

1 reference

T-box transcription factor TBX20 mutations in Chinese patients with congenital heart disease

21 January 2018

1 reference

Cardiac developmental biology: from flies to humans.

21 January 2018

1 reference

CRELD1 andGATA4 gene analysis in patients with nonsyndromic atrioventricular canal defects

21 January 2018

1 reference

ZFPM2/FOG2 andHEY2 genes analysis in nonsyndromic tricuspid atresia

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FCA.10.10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20462343%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference