(Q37758369)

22 August 2017

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title

Pathophysiological roles of WNK kinases in the kidney (English)

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22 August 2017

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Shinichi Uchida

1

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22 August 2017

publication date

21 May 2010

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22 August 2017

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22 August 2017

volume

460

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22 August 2017

issue

4

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22 August 2017

page(s)

695-702

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Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate

22 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00424-010-0848-7

WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0848-7

WNK kinases regulate thiazide-sensitive Na-Cl cotransport

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-010-0848-7

Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0848-7

WNK1 kinase isoform switch regulates renal potassium excretion.

21 January 2018

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12 December 2020

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

1 reference

12 December 2020

Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice

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12 December 2020

Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase

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12 December 2020

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

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12 December 2020

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis

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12 December 2020

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule

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12 December 2020

WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter

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12 December 2020

WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway

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12 December 2020

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

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12 December 2020

An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis

1 reference

12 December 2020

The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex

1 reference

12 December 2020

Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone

1 reference

12 December 2020

Renal and brain isoforms of WNK3 have opposite effects on NCCT expression

1 reference

12 December 2020

Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model

1 reference

12 December 2020

WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway

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12 December 2020

WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway

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12 December 2020

ANG II provokes acute trafficking of distal tubule Na+-Cl(-) cotransporter to apical membrane

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12 December 2020

Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney

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12 December 2020

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure

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12 December 2020

WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism

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12 December 2020

WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia

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12 December 2020

WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.

1 reference

12 December 2020

Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4.

1 reference

12 December 2020

Deletion of WNK1 first intron results in misregulation of both isoforms in renal and extrarenal tissues

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12 December 2020

WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.

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12 December 2020

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

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12 December 2020

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms

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12 December 2020

WNK1, a Gene within a Novel Blood Pressure Control Pathway, Tissue-Specifically Generates Radically Different Isoforms with and without a Kinase Domain

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12 December 2020

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

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12 December 2020

The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion

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12 December 2020

From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.

1 reference

12 December 2020

Increased chloride reabsorption as an inherited renal tubular defect in familial type II pseudohypoaldosteronism

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12 December 2020

Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform

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12 December 2020

A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter, NKCC1.

1 reference

12 December 2020

Domains of WNK1 kinase in the regulation of ROMK1

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12 December 2020

WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion

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12 December 2020

WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia

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12 December 2020

Human hypertension caused by mutations in WNK kinases

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12 December 2020

Intersectin links WNK kinases to endocytosis of ROMK1

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12 December 2020

The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney

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12 December 2020

WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

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12 December 2020

Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.

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12 December 2020

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

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12 December 2020

Role of the WNK-activated SPAK kinase in regulating blood pressure

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12 December 2020

WNK1 activates SGK1 to regulate the epithelial sodium channel.

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12 December 2020

Short-term stimulation of the thiazide-sensitive Na+-Cl- cotransporter by vasopressin involves phosphorylation and membrane translocation.

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12 December 2020

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

1 reference

12 December 2020

10.1007/S00424-010-0848-7

Identifiers

DOI

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22 August 2017

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