(Q37761761)

22 August 2017

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title

Changing paradigms in thiology from antioxidant defense toward redox regulation (English)

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22 August 2017

Leopold Flohé

1

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22 August 2017

language of work or name

English

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publication date

1 January 2010

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22 August 2017

published in

Methods in Enzymology

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22 August 2017

volume

473

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22 August 2017

page(s)

1-39

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Redox regulation of cell survival by the thioredoxin superfamily: an implication of redox gene therapy in the heart

22 August 2017

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Bacterial Ohr and OsmC paralogues define two protein families with distinct functions and patterns of expression

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Folding and stability of the Z and S(iiyama) genetic variants of human alpha1-antitrypsin

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Is *NO news bad news in acute respiratory distress syndrome?

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Regulation of PTP1B via glutathionylation of the active site cysteine 215

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Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

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Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

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7 January 2021

Thiol chemistry in peroxidase catalysis and redox signaling

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Trends in selenium biochemistry.

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ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

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Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

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Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer

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7 January 2021

Interleukin-1-induced nuclear factor kappa B activation is inhibited by overexpression of phospholipid hydroperoxide glutathione peroxidase in a human endothelial cell line

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7 January 2021

Kinetic study of the reaction of glutathione peroxidase with peroxynitrite

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Peroxynitrite reductase activity of bacterial peroxiredoxins

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Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity

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7 January 2021

Peroxidases of trypanosomatids

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Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes

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7 January 2021

Kinetics and mechanisms of catalase in peroxisomes of the mitochondrial fraction

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7 January 2021

Hydroperoxide metabolism in mammalian organs

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7 January 2021

Radiation Protection with Sulphur and Some Sulphur-containing Compounds

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7 January 2021

Protein-sulfenic acid stabilization and function in enzyme catalysis and gene regulation.

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7 January 2021

Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes

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7 January 2021

Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4.

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7 January 2021

Evidence for the involvement of sulfhydryl oxidation in the regulation of fat cell hexose transport by insulin

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7 January 2021

ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis

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7 January 2021

The peroxiredoxin and glutathione peroxidase families in Chlamydomonas reinhardtii

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7 January 2021

H2O2 sensing through oxidation of the Yap1 transcription factor

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7 January 2021

A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation

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7 January 2021

Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation

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7 January 2021

Mammalian antioxidant defenses are not inducible by H2O2.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Redox control, redox signaling, and redox homeostasis in plant cells.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Redox signal integration: from stimulus to networks and genes

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7 January 2021

Gamma-glutamyltransferase-dependent prooxidant reactions: a factor in multiple processes

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7 January 2021

Free radicals in the physiological control of cell function

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7 January 2021

Peroxiredoxins in bacterial antioxidant defense.

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7 January 2021

Human peroxiredoxin 5 is a peroxynitrite reductase

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7 January 2021

Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas

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7 January 2021

The inhibitory effect at the hexokinase level of disulphides on glucose metabolism in human erythrocytes

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7 January 2021

Novel application of 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole to identify cysteine sulfenic acid in the AhpC component of alkyl hydroperoxide reductase.

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7 January 2021

Roles for the two cysteine residues of AhpC in catalysis of peroxide reduction by alkyl hydroperoxide reductase from Salmonella typhimurium.

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7 January 2021

The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution

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7 January 2021

Antioxidants and survival time of mice exposed to multiple sublethal doses of x-irradiation

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7 January 2021

Bioflavonoids and survival time of mice exposed to multiple sublethal doses of x-irradiation

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7 January 2021

Cellular regulation by protein phosphorylation: a historical overview

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7 January 2021

The glutathione peroxidase reaction: molecular basis of the antioxidant function of selenium in mammals

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7 January 2021

Superoxide dismutase for therapeutic use: clinical experience, dead ends and hopes

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7 January 2021

The labour pains of biochemical selenology: the history of selenoprotein biosynthesis

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7 January 2021

Peroxidase: a term of many meanings

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7 January 2021

Glutathione peroxidase: a selenoenzyme

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7 January 2021

Tryparedoxin peroxidase of Leishmania donovani: molecular cloning, heterologous expression, specificity, and catalytic mechanism

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7 January 2021

Role of superoxide radical in mitochondrial dehydrogenase reactions

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7 January 2021

Signaling functions of reactive oxygen species.

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7 January 2021

Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.

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7 January 2021

Isoforms of nitric oxide synthase Characterization and purification from different cell types

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7 January 2021

The role of endotoxin in protection of adult rats from oxygen-induced lung toxicity

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7 January 2021

Nucleoredoxin, a novel thioredoxin family member involved in cell growth and differentiation

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7 January 2021

The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled

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7 January 2021

The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): thioredoxin mRNA is elevated in some human tumors

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7 January 2021

Oxygen poisoning and x-irradiation: a mechanism in common

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7 January 2021

Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx) in Rat Testis Nuclei Is Bound to Chromatin

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7 January 2021

Catalytic characteristics of tryparedoxin

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7 January 2021

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity

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7 January 2021

A Novel Reaction Mechanism for the Formation ofS-Nitrosothiolin Vivo

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7 January 2021

Hydrogen peroxide as a cell-survival signaling molecule.

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7 January 2021

Osmotic induction of gene osmC expression in Escherichia coli K12

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7 January 2021

Über die Katalyse des Hydroperoxydes

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7 January 2021

Aging: a theory based on free radical and radiation chemistry

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7 January 2021

Release of a macromolecular protein component from human erythrocyte ghosts

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7 January 2021

Tumour necrosis factor-alpha induces superoxide anion generation in mitochondria of L929 cells

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7 January 2021

Glutaredoxins and oxidative stress defense in yeast

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7 January 2021

Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate reductase dependent upon glutathione

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7 January 2021

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Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification

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7 January 2021

Sulfur and selenium: the role of oxidation state in protein structure and function

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7 January 2021

Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis

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7 January 2021

Influence of selenium, antioxidants and type of yeast on vitamin E deficiency in the adult chicken

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7 January 2021

Redefining oxidative stress

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7 January 2021

The plant immune system

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7 January 2021

Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes.

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7 January 2021

Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha.

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7 January 2021

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

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7 January 2021

Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress

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7 January 2021

Iodination of bacteria: a bactericidal mechanism

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7 January 2021

Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression

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7 January 2021

NMR studies of the interaction of tryparedoxin with redox-inactive substrate homologues

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Crystallographic data of the selenoenzyme glutathione peroxidase

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Structural and functional features of theEscherichia colihydroperoxide resistance protein OsmC

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes

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7 January 2021

Respiratory chain linked H(2)O(2) production in pigeon heart mitochondria

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Superoxide radicals as precursors of mitochondrial hydrogen peroxide

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Superoxide production by rabbit pulmonary alveolar macrophages

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Probing the presumed catalytic triad of selenium-containing peroxidases by mutational analysis of phospholipid hydroperoxide glutathione peroxidase (PHGPx).

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Functional interaction of phospholipid hydroperoxide glutathione peroxidase with sperm mitochondrion-associated cysteine-rich protein discloses the adjacent cysteine motif as a new substrate of the selenoperoxidase.

1 reference

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7 January 2021

The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases.

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

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7 January 2021

Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase

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7 January 2021

Free radicals and inflammation: protection of synovial fluid by superoxide dismutase

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7 January 2021

Pathogen recognition and inflammatory signaling in innate immune defenses

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7 January 2021

The discovery of nitric oxide as the endogenous nitrovasodilator

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7 January 2021

Pag, a putative tumor suppressor, interacts with the Myc Box II domain of c-Myc and selectively alters its biological function and target gene expression

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Complex III releases superoxide to both sides of the inner mitochondrial membrane

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Nrf2 target genes are induced under marginal selenium-deficiency

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7 January 2021

Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection

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7 January 2021

Activation of rabbit liver fructose diphosphatase by coenzyme A and acyl carrier protein

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7 January 2021

Redox control of catalytic activities of membrane-associated protein tyrosine kinases.

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7 January 2021

Peroxiredoxin 1 and its role in cell signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

The mitochondrial site of superoxide formation

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7 January 2021

Cell respiration and formation of reactive oxygen species: facts and artefacts

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7 January 2021

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin

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7 January 2021

Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Identification of cysteine sulfenic acid in AhpC of alkyl hydroperoxide reductase

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Discovering mechanisms of signaling-mediated cysteine oxidation.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Pathways of peroxynitrite oxidation of thiol groups

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7 January 2021

Interleukin 1-alpha and tumor necrosis factor-alpha induce oxygen radical production in mesangial cells

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7 January 2021

The Lipoxygenase of Reticulocytes. Purification, Characterization and Biological Dynamics of the Lipoxygenase; Its Identity with the Respiratory Inhibitors of the Reticulocyte

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7 January 2021

The crystal structure of seleno-glutathione peroxidase from human plasma at 2.9 A resolution

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

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7 January 2021

Selenium: Biochemical Role as a Component of Glutathione Peroxidase

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7 January 2021

Active site mutagenesis and phospholipid hydroperoxide reductase activity of poplar type II peroxiredoxin

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7 January 2021

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

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7 January 2021

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

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7 January 2021

Antioxidant activity of the anti-inflammatory compound ebselen: a reversible cyclization pathway via selenenic and seleninic acid intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Silencing of the thioredoxin gene in Trypanosoma brucei brucei

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Catalytic and chemical competence of regulation of cdc25 phosphatase by oxidation/reduction

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

On the nature of selenium toxicity and carcinostatic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

The putative glutathione peroxidase gene of Plasmodium falciparum codes for a thioredoxin peroxidase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Identification and molecular analysis of oxyR-regulated promoters important for the bacterial adaptation to oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Reactive oxygen species in cell signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

The catalytic site of glutathione peroxidases.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Trypanosoma brucei and Trypanosoma cruzi tryparedoxin peroxidases catalytically detoxify peroxynitrite via oxidation of fast reacting thiols.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

The mycobacterial thioredoxin peroxidase can act as a one-cysteine peroxiredoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Dual function of the selenoprotein PHGPx during sperm maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Reversing the Inactivation of Peroxiredoxins Caused by Cysteine Sulfinic Acid Formation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Signaling pathways involved in phase II gene induction by alpha, beta-unsaturated aldehydes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Enzyme-independent formation of nitric oxide in biological tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

One- and two-electron oxidation of reduced glutathione by peroxidases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

Identification and characterization of a new organic hydroperoxide resistance (ohr) gene with a novel pattern of oxidative stress regulation from Xanthomonas campestris pv. phaseoli

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2973001-9

7 January 2021

10.1016/S0076-6879(10)73001-9

Identifiers

DOI

1 reference

22 August 2017

1 reference