(Q37763950)

22 August 2017

1 reference

title

Glycobiology of the Leishmania parasite and emerging targets for antileishmanial drug discovery (English)

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22 August 2017

0 references

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Sunandini Chandra

1

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22 August 2017

Dipali Ruhela

series ordinal

2

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22 August 2017

Anindita Deb

series ordinal

3

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22 August 2017

Ram A Vishwakarma

series ordinal

4

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22 August 2017

language of work or name

English

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publication date

1 July 2010

1 reference

Expert Opinion on Therapeutic Targets

22 August 2017

published in

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22 August 2017

volume

14

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22 August 2017

issue

7

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22 August 2017

page(s)

739-757

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Pentavalent antimonials: new perspectives for old drugs

22 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Amphotericin B deoxycholate treatment of visceral leishmaniasis with newer modes of administration and precautions: a study of 938 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

A comparative review of conventional and lipid formulations of amphotericin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Miltefosine affects lipid metabolism in Leishmania donovani promastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Miltefosine to treat leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Effect of the lysophospholipid analogues edelfosine, ilmofosine and miltefosine against Leishmania amazonensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Leishmanicidal activity of edelfosine, miltefosine and ilmofosine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Clinical status of agents being developed for leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Designing glycoconjugate biosynthesis for an insidious intent: phosphoglycan assembly in Leishmania parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Transbilayer inhibition of protein kinase C by the lipophosphoglycan from Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

The lipophosphoglycan of Leishmania parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

The role of phosphoglycans in Leishmania-sand fly interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Proteophosphoglycans of Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Mammalian GPI proteins: sorting, membrane residence and functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Recent developments in the cell biology and biochemistry of glycosylphosphatidylinositol lipids (review).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

High lateral mobility of endogenous and transfected alkaline phosphatase: a phosphatidylinositol-anchored membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Inhibitors of glycosyl-phosphatidylinositol anchor biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Inhibition of the GlcNAc transferase of the glycosylphosphatidylinositol anchor biosynthesis in African trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

The N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Substrate specificity of the N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol membrane anchor biosynthesis in African trypanosomes and human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Substrate specificity of the Plasmodium falciparum glycosylphosphatidylinositol biosynthetic pathway and inhibition by species-specific suicide substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Differences between the trypanosomal and human GlcNAc-PI de-N-acetylases of glycosylphosphatidylinositol membrane anchor biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Parasite and mammalian GPI biosynthetic pathways can be distinguished using synthetic substrate analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Probing enzymes late in the trypanosomal glycosylphosphatidylinositol biosynthetic pathway with synthetic glycosylphosphatidylinositol analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Glycosylation of influenza virus proteins in the presence of fluoroglucose occurs via a different pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Dissecting glycoprotein biosynthesis by the use of specific inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Inhibition of glycosyl-phosphatidylinositol biosynthesis in Plasmodium falciparum by C-2 substituted mannose analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Nature of glycosylphosphatidylinositols produced by mouse embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Developmental stage-specific biosynthesis of glycosylphosphatidylinositol anchors in intraerythrocytic Plasmodium falciparum and its inhibition in a novel manner by mannosamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Apparent lack of N-glycosylation in the asexual intraerythrocytic stage of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Toxicity of myristic acid analogs toward African trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Identification and partial characterization of two eukaryotic UDP-galactopyranose mutases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Persistence without pathology in phosphoglycan-deficient Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

A role for insect galectins in parasite survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Golgi GDP-mannose uptake requires Leishmania LPG2. A member of a eukaryotic family of putative nucleotide-sugar transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Mannose enters mammalian cells using a specific transporter that is insensitive to glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Genetic characterization of glucose transporter function in Leishmania mexicana

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Metabolic changes in glucose transporter-deficient Leishmania mexicana and parasite virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

PMM (PMM1), the human homologue of SEC53 or yeast phosphomannomutase, is localized on chromosome 22q13

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13, in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Molecular basis of carbohydrate-deficient glycoprotein syndromes type I with normal phosphomannomutase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Phosphoglycan repeat-deficient Leishmania mexicana parasites remain infectious to macrophages and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Utilization of a carbohydrate reserve comprised primarily of mannose by Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Leishmania beta-1,2-mannan is assembled on a mannose-cyclic phosphate primer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Magnesium ion requirements for yeast enolase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Multifunctional alpha-enolase: its role in diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

A study of cutaneous lesions caused by Leishmania mexicana in plasminogen-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Identification of a novel plasmin(ogen)-binding motif in surface displayed alpha-enolase of Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Enolase as a plasminogen binding protein in Leishmania mexicana

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

The crystal structure of Trypanosoma brucei enolase: visualisation of the inhibitory metal binding site III and potential as target for selective, irreversible inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Structural flexibility in Trypanosoma brucei enolase revealed by X-ray crystallography and molecular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Functional identification of a Leishmania gene related to the peroxin 2 gene reveals common ancestry of glycosomes and peroxisomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei : The glycosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

21 January 2018

How peroxisomes arise.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Identification of peroxisomal targeting signals located at the carboxy terminus of four peroxisomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Molecular characterization of the hexokinase gene from Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Biogenesis of glycosomes of Trypanosoma brucei: an in vitro model of 3-phosphoglycerate kinase import

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Purine and pyrimidine metabolism in the Trypanosomatidae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Antiparasitic chemotherapy: tinkering with the purine salvage pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

A unique surface membrane anchored purine-salvage enzyme is conserved among a group of primitive eukaryotic human pathogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Xanthine phosphoribosyltransferase from Leishmania donovani. Molecular cloning, biochemical characterization, and genetic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Predictive computational models of substrate binding by a nucleoside transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Antitrypanosomal Effect of Allopurinol: Conversion in Vivo to Aminopyrazolopyrimidine Nucleotides by Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Rational design of selective submicromolar inhibitors of Tritrichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Adenosine kinase mediates high affinity adenosine salvage in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Thiol-based redox metabolism of protozoan parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Transgenic tobacco plants overexpressing glyoxalase enzymes resist an increase in methylglyoxal and maintain higher reduced glutathione levels under salinity stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

A glutathione-specific aldose reductase of Leishmania donovani and its potential implications for methylglyoxal detoxification pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Glyoxalase I from Leishmania donovani: a potential target for anti-parasite drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Catalysis and structural properties of Leishmania infantum glyoxalase II: trypanothione specificity and phylogeny

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Structure of Leishmania mexicana Phosphomannomutase Highlights Similarities with Human Isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Hydrophobic mannosides act as acceptors for trypanosome α-mannosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

In vitro activity of perifosine: a novel alkylphospholipid against the promastigote stage of Leishmania species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Synthesis of β-d-Galp-(1→4)-α-d-Manp methanephosphonate, a substrate analogue for the elongating α-d-mannosyl phosphate transferase in the Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Synthesis of potential bisubstrate inhibitors of Leishmania elongating α-d-mannosyl phosphate transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

Localization of the initial steps in alkoxyphospholipid biosynthesis in glycosomes (microbodies) of Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

The occurrence of glycosomes (microbodies) in the promastigote stage of four major Leishmania species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.495125

10.1517/14728222.2010.495125

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference