(Q37769153)

22 August 2017

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title

Important aspects of Toll-like receptors, ligands and their signaling pathways (English)

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22 August 2017

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Z L Chang

1

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22 August 2017

publication date

1 July 2010

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22 August 2017

published in

Inflammation Research

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22 August 2017

volume

59

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22 August 2017

issue

10

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22 August 2017

page(s)

791-808

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Human lymphatic endothelial cells express multiple functional TLRs.

22 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Ligands, cell-based models, and readouts required for Toll-like receptor action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Cutting edge: diminished T cell TLR expression and function modulates the immune response in human filarial infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

TLR3 can directly trigger apoptosis in human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Engagement of TLR3, TLR7, and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

The signal transduction pathway leading from the toll receptor to nuclear localization of dorsal transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

MicroRNA biogenesis: there's more than one way to skin a cat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Functional activity of MD-2 polymorphic variant is significantly different in soluble and TLR4-bound forms: decreased endotoxin binding by G56R MD-2 and its rescue by TLR4 ectodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00011-010-0208-2

Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.

21 January 2018

1 reference

12 December 2020

T-cell reactivity to human HSP60 in oligo-articular juvenile chronic arthritis is associated with a favorable prognosis and the generation of regulatory cytokines in the inflamed joint

1 reference

12 December 2020

Toll like receptor-9 agonists stimulate prostate cancer invasion in vitro

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12 December 2020

TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer.

1 reference

12 December 2020

Plant disease resistance: commonality and novelty in multicellular innate immunity

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12 December 2020

The tumor microenvironment and its role in promoting tumor growth

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12 December 2020

Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.

1 reference

12 December 2020

A phase I/II trial of TLR-7 agonist immunotherapy in chronic lymphocytic leukemia

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12 December 2020

IRAK-M is a negative regulator of Toll-like receptor signaling

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12 December 2020

Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene

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12 December 2020

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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12 December 2020

A conserved signaling pathway: the Drosophila toll-dorsal pathway

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12 December 2020

A Toll-like receptor recognizes bacterial DNA

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12 December 2020

Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine.

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12 December 2020

Adding fuel to fire: microRNAs as a new class of mediators of inflammation.

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12 December 2020

TLRs and chronic inflammation.

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12 December 2020

Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA.

1 reference

12 December 2020

Toll-like receptors in skin

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12 December 2020

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

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12 December 2020

Phase I trial of toll-like receptor 9 agonist PF-3512676 with and following rituximab in patients with recurrent indolent and aggressive non Hodgkin's lymphoma

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12 December 2020

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

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12 December 2020

Advances in microRNAs: implications for immunity and inflammatory diseases

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12 December 2020

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

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12 December 2020

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

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12 December 2020

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12 December 2020

TLR3 ligand polyinosinic:polycytidylic acid induces IL-17A and IL-21 synthesis in human Th cells.

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12 December 2020

Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.

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12 December 2020

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

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12 December 2020

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

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12 December 2020

Assessment of expression of toll-like receptors 2, 3 and 4 in laryngeal carcinoma

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12 December 2020

Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis

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12 December 2020

miR-155/BIC as an oncogenic microRNA.

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12 December 2020

Role of Toll-like receptors in infection and immunity: clinical implications

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12 December 2020

Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling

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12 December 2020

NF-kappa B regulates the LPS-induced expression of interleukin 12 p40 in murine peritoneal macrophages: roles of PKC, PKA, ERK, p38 MAPK, and proteasome

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12 December 2020

"Spicing up" of the immune system by curcumin

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12 December 2020

Toll-like receptors and Type I interferons

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12 December 2020

Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer

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12 December 2020

Immune responses to malignancies

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12 December 2020

TLR11 activation of dendritic cells by a protozoan profilin-like protein.

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12 December 2020

Toll-like receptors and acquired immunity

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12 December 2020

TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance

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12 December 2020

The functions of animal microRNAs

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12 December 2020

The danger model: a renewed sense of self

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12 December 2020

Identification of clustered microRNAs using an ab initio prediction method

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12 December 2020

Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.

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12 December 2020

TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer

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12 December 2020

Melanoma cell lines are responsive in vitro to lipopolysaccharide and express TLR-4.

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12 December 2020

Toll-like receptor-7 tolerizes malignant B cells and enhances killing by cytotoxic agents

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12 December 2020

Triggering of Toll-like receptor 4 expressed on human head and neck squamous cell carcinoma promotes tumor development and protects the tumor from immune attack.

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12 December 2020

Functional significance of gene polymorphisms in the promoter of myeloid differentiation-2

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12 December 2020

Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells

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12 December 2020

Innovative strategies for co-delivering antigens and CpG oligonucleotides

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12 December 2020

The evolution of vertebrate Toll-like receptors

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12 December 2020

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

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12 December 2020

Difference in susceptibility to gram-negative urinary tract infection between C3H/HeJ and C3H/HeN mice

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12 December 2020

High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer

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12 December 2020

Human skin endothelial cells can express all 10 TLR genes and respond to respective ligands

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12 December 2020

Modulation of immune responses through direct activation of Toll-like receptors to T cells

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12 December 2020

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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12 December 2020

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

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12 December 2020

HMGB1 mediates endogenous TLR2 activation and brain tumor regression

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12 December 2020

TLR accessory molecules

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12 December 2020

Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors

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12 December 2020

miRGen 2.0: a database of microRNA genomic information and regulation

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12 December 2020

Towards subtlety: understanding the role of Toll-like receptor signaling in susceptibility to human infections

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12 December 2020

Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15

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12 December 2020

Activated macrophages in the tumour microenvironment-dancing to the tune of TLR and NF-kappaB

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12 December 2020

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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12 December 2020

Toll-like receptors on tumor cells facilitate evasion of immune surveillance

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12 December 2020

Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation

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12 December 2020

Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation

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12 December 2020

Cloning and expression profiling of small RNAs expressed in the mouse ovary

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12 December 2020

Human keratinocyte Toll-like receptors promote distinct immune responses

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12 December 2020

"Re-educating" tumor-associated macrophages by targeting NF-kappaB.

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12 December 2020

TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements

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12 December 2020

Pathogen recognition and innate immunity

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12 December 2020

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

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12 December 2020

The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs

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12 December 2020

Human lung cancer cells express functionally active Toll-like receptor 9

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12 December 2020

Leucine-rich repeats and pathogen recognition in Toll-like receptors.

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12 December 2020

The roles of TLRs, RLRs and NLRs in pathogen recognition

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12 December 2020

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

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12 December 2020

TLR signaling by tumor and immune cells: a double-edged sword

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12 December 2020

New developments in our understanding of acne pathogenesis and treatment

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12 December 2020

The toll-like receptor pathway: a novel mechanism of infection-induced carcinogenesis of prostate epithelial cells

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12 December 2020

Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury

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12 December 2020

Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein

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12 December 2020

Immunodeficiency: UNC-93B gets a toll call

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12 December 2020

Host innate immune receptors and beyond: making sense of microbial infections

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12 December 2020

MicroRNAs and immunity: tiny players in a big field

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12 December 2020

Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia

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12 December 2020

Inflammation, cancer and chemoresistance: taking advantage of the toll-like receptor signaling pathway

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12 December 2020

Upregulation of Toll-like receptor (TLR) expression and release of cytokines from P815 mast cells by GM-CSF.

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12 December 2020

Regulation of macrophage function in tumors: the multifaceted role of NF-kappaB.

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12 December 2020

MicroRNA-155 is induced during the macrophage inflammatory response

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12 December 2020

Toll-like receptors and innate immunity

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12 December 2020

MicroRNAs: new regulators of immune cell development and function

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12 December 2020

Sequence Variants in Toll-Like Receptor Gene Cluster (TLR6-TLR1-TLR10) and Prostate Cancer Risk

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12 December 2020

Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori

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12 December 2020

Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment

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12 December 2020

Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors

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12 December 2020

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

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12 December 2020

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

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12 December 2020

Inferences, questions and possibilities in Toll-like receptor signalling

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12 December 2020

How location governs toll-like receptor signaling

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12 December 2020

Toll-like receptor 3 expressed by melanoma cells as a target for therapy?

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12 December 2020

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling

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12 December 2020

The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy

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12 December 2020

Of mice and man: TLR11 (finally) finds profilin

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12 December 2020

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

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12 December 2020

Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria

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12 December 2020

MicroRNA in the immune system, microRNA as an immune system

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12 December 2020

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

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12 December 2020

Requirement of bic/microRNA-155 for normal immune function

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12 December 2020

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

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12 December 2020

Switching from repression to activation: microRNAs can up-regulate translation

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12 December 2020

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

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12 December 2020

miRBase: tools for microRNA genomics

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12 December 2020

Immunomodulated signaling in macrophages: Studies on activation of Raf-1, MAPK, cPLA(2) and secretion of IL-12

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12 December 2020

Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity

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12 December 2020

A toll-like receptor that prevents infection by uropathogenic bacteria

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12 December 2020

Toll-like receptors: key activators of leucocytes and regulator of haematopoiesis.

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12 December 2020

Role of toll-like receptors in tissue repair and tumorigenesis

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12 December 2020

Polymorphisms in Toll-like receptor genes and risk of cancer

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12 December 2020

Inflammation and cancer: a double-edged sword.

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12 December 2020

The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893.

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12 December 2020

Toll-like receptors and cancer

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12 December 2020

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

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12 December 2020

Localization of Toll-like receptors on epididymal epithelial cells and spermatozoa

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12 December 2020

Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals

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12 December 2020

Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide

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12 December 2020

Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets

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12 December 2020

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

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12 December 2020

Mechanism of anticancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling

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12 December 2020

CpG oligodeoxynucleotides as TLR9 agonists: therapeutic applications in cancer.

1 reference

12 December 2020

TLRs and innate immunity

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12 December 2020

Genetic aspects of inflammation and cancer

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12 December 2020

Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity

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12 December 2020

TLR3 deficiency in patients with herpes simplex encephalitis

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12 December 2020

Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod

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12 December 2020

Nonimmune cells in inflammatory bowel disease: from victim to villain

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12 December 2020

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

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12 December 2020

Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1.

1 reference

12 December 2020

Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis

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12 December 2020

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

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12 December 2020

A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity

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12 December 2020

Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila

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12 December 2020

Increased toll-like receptor 9 expression in cervical neoplasia

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12 December 2020

Cancer and inflammation: implications for pharmacology and therapeutics

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12 December 2020

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

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12 December 2020

Summary of the International Cancer Microenvironment from meeting in Pittsburgh, Pennsylvania on October 3-6, 1999.

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12 December 2020

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals

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12 December 2020

Toll-like receptors: critical proteins linking innate and acquired immunity

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12 December 2020

'Toll' gates for future immunotherapy

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12 December 2020

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.

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12 December 2020

Toll-like receptor triggering in cord blood mesenchymal stem cells

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12 December 2020

Accumulation of miR-155 and BIC RNA in human B cell lymphomas

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12 December 2020

A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis

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12 December 2020

How important are Toll-like receptors for antimicrobial responses?

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12 December 2020

Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study

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12 December 2020

10.1007/S00011-010-0208-2

Identifiers

DOI

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22 August 2017

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