(Q37340298)

19 August 2017

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title

Toll-like receptors and cancer (English)

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19 August 2017

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2

Ruslan Medzhitov

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19 August 2017

Seth Rakoff-Nahoum

1

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19 August 2017

language of work or name

English

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publication date

4 December 2008

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19 August 2017

published in

Nature Reviews Cancer

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19 August 2017

volume

9

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19 August 2017

issue

1

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19 August 2017

page(s)

57-63

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Inflammation and cancer: back to Virchow?

19 August 2017

cites work

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31 March 2020

Inflammation and cancer

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NF-kappaB: linking inflammation and immunity to cancer development and progression

31 March 2020

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31 March 2020

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Signaling pathways downstream of pattern-recognition receptors and their cross talk

31 March 2020

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Approaching the asymptote? Evolution and revolution in immunology

31 March 2020

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Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

31 March 2020

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Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells

31 March 2020

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HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway

31 March 2020

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Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.

31 March 2020

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Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4.

31 March 2020

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The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway

31 March 2020

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Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis

31 March 2020

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High mobility group box 1 protein interacts with multiple Toll-like receptors

31 March 2020

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Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein

31 March 2020

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Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation

31 March 2020

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TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation

31 March 2020

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Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4

31 March 2020

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The extra domain A of fibronectin activates Toll-like receptor 4.

31 March 2020

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Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4.

31 March 2020

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The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages

31 March 2020

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Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.

31 March 2020

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Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

31 March 2020

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Regulation of lung injury and repair by Toll-like receptors and hyaluronan

31 March 2020

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Hyaluronan fragments stimulate endothelial recognition of injury through TLR4.

31 March 2020

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Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2.

31 March 2020

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Multi-layered regulation of intestinal antimicrobial defense

31 March 2020

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Defensins: antimicrobial peptides of innate immunity

31 March 2020

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MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection

31 March 2020

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Regulation of phagosome maturation by signals from toll-like receptors

31 March 2020

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Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

31 March 2020

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Regulation of the expression of inducible nitric oxide synthase

31 March 2020

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Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B

31 March 2020

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Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria.

31 March 2020

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Toll-like receptor-4 is involved in eliciting an LPS-induced oxidative burst in neutrophils.

31 March 2020

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Physiological and molecular mechanisms of lymphocyte homing

31 March 2020

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Rapid leukocyte integrin activation by chemokines

31 March 2020

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Toll-like receptors control activation of adaptive immune responses

31 March 2020

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Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation

31 March 2020

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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

31 March 2020

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Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites

31 March 2020

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Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization

31 March 2020

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Toll-like receptor control of the adaptive immune responses

31 March 2020

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

31 March 2020

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Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

31 March 2020

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Regulating B-cell activation and survival in response to TLR signals

31 March 2020

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Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate.

31 March 2020

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Differential induction of endotoxin tolerance by lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli

31 March 2020

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Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.

31 March 2020

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Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin

31 March 2020

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Toll-like receptors' two-edged sword: when immunity meets apoptosis.

31 March 2020

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The apoptotic signaling pathway activated by Toll-like receptor-2

31 March 2020

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Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages

31 March 2020

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The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

31 March 2020

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TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apoptosis in vivo

31 March 2020

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Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity

31 March 2020

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Toll-like receptors in brain development and homeostasis.

31 March 2020

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Toll-like receptors and innate immunity in gut homeostasis and pathology

31 March 2020

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Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine.

31 March 2020

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Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury

31 March 2020

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Toll-like receptors modulate adult hippocampal neurogenesis

31 March 2020

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Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis

31 March 2020

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Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury

31 March 2020

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Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation.

31 March 2020

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A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity

31 March 2020

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Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

31 March 2020

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Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C

31 March 2020

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Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function

31 March 2020

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Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis

31 March 2020

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Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury

31 March 2020

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MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis

31 March 2020

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Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis

31 March 2020

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Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury

31 March 2020

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Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration

31 March 2020

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Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4

31 March 2020

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Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors.

31 March 2020

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Mammalian toll-like receptors: from endogenous ligands to tissue regeneration.

31 March 2020

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TLR4 enhances TGF-beta signaling and hepatic fibrosis

31 March 2020

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Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

31 March 2020

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

31 March 2020

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The role of Toll-like receptors in non-infectious lung injury

31 March 2020

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Cancer relapse under chemotherapy: why TLR2/4 receptor agonists can help

31 March 2020

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Randomised study of immunotherapy with OK-432 in uterine cervical carcinoma

31 March 2020

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Postoperative immunochemotherapy including streptococcal lysate OK-432 is effective for patients with gastric cancer and serosal invasion

31 March 2020

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Therapy for oral squamous cell carcinoma by tegafur and streptococcal agent OK-432 in combination with radiotherapy: association of the therapeutic effect with differentiation and apoptosis in the cancer cells

31 March 2020

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Mechanism of anticancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling

31 March 2020

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Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors

31 March 2020

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Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation

31 March 2020

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Bacillus Calmette-Guerin and bladder cancer

31 March 2020

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Development of TLR9 agonists for cancer therapy

31 March 2020

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Phase II trial of intravenous endotoxin in patients with colorectal and non-small cell lung cancer

31 March 2020

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The in vivo antitumoral effects of lipopolysaccharide against glioblastoma multiforme are mediated in part by Toll-like receptor 4.

31 March 2020

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Antitumor activity of the TLR-5 ligand flagellin in mouse models of cancer

31 March 2020

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Therapeutic anti-tumor immunity triggered by injections of immunostimulating single-stranded RNA.

31 March 2020

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The use of Toll-like receptor-7 agonist in the treatment of basal cell carcinoma: an overview

31 March 2020

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Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia

31 March 2020

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Phase 1 trial of a CpG oligodeoxynucleotide for patients with recurrent glioblastoma

31 March 2020

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TLR3 can directly trigger apoptosis in human cancer cells.

31 March 2020

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Stimulation of TLR9 with CpG ODN enhances apoptosis of glioma and prolongs the survival of mice with experimental brain tumors

31 March 2020

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Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation

31 March 2020

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Coupling of endothelial injury and repair: an analysis using an in vivo experimental model

31 March 2020

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Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis

31 March 2020

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Epstein-Barr virus induces MCP-1 secretion by human monocytes via TLR2.

31 March 2020

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Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication.

31 March 2020

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Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice

31 March 2020

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Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation

31 March 2020

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Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins

31 March 2020

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Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88.

31 March 2020

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Innate immune recognition of the extracellular mucosal pathogen, Helicobacter pylori

31 March 2020

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Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells

31 March 2020

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The role of endotoxin/lipopolysaccharide in surgically induced tumour growth in a murine model of metastatic disease

31 March 2020

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Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion

31 March 2020

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Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression

31 March 2020

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Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling

31 March 2020

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Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors

31 March 2020

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Toll-like receptors mediate proliferation and survival of multiple myeloma cells

31 March 2020

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Toll-like receptors on tumor cells facilitate evasion of immune surveillance

31 March 2020

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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

31 March 2020

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Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

31 March 2020

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Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88

31 March 2020

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Lessons from hereditary colorectal cancer

31 March 2020

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Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

31 March 2020

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Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis

31 March 2020

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Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

31 March 2020

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Role of toll-like receptors in spontaneous commensal-dependent colitis

31 March 2020

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Role of AID in tumorigenesis

31 March 2020

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Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination

31 March 2020

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Macrophage migration inhibitory factor: a probable link between inflammation and cancer

31 March 2020

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The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

31 March 2020

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An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells

31 March 2020

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Endotoxin/lipopolysaccharide activates NF-kappa B and enhances tumor cell adhesion and invasion through a beta 1 integrin-dependent mechanism

31 March 2020

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Recognition of microorganisms and activation of the immune response

31 March 2020

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The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta

31 March 2020

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Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

31 March 2020

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Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors

31 March 2020

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Cancer as a robust system: implications for anticancer therapy

31 March 2020

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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

31 March 2020

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Polymorphisms in Toll-like receptor genes and risk of cancer

31 March 2020

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Molecular interactions between dying tumor cells and the innate immune system determine the efficacy of conventional anticancer therapies

31 March 2020

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Association of Toll-like receptor-4 (Asp299Gly and Thr399Ileu) gene polymorphisms with gastritis and precancerous lesions

31 March 2020

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Genetic polymorphisms of TLR3 are associated with Nasopharyngeal carcinoma risk in Cantonese population

31 March 2020

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Sequence variants in toll-like receptor 10 are associated with nasopharyngeal carcinoma risk.

31 March 2020

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Sequence Variants of Toll-Like Receptor 4 and Susceptibility to Prostate Cancer

31 March 2020

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Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study

31 March 2020

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Sequence Variants in Toll-Like Receptor Gene Cluster (TLR6-TLR1-TLR10) and Prostate Cancer Risk

31 March 2020

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Association between Toll-Like Receptor Gene Cluster (TLR6, TLR1, and TLR10) and Prostate Cancer

31 March 2020

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Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk

31 March 2020

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Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma

31 March 2020

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Microsatelite GT polymorphism in the toll-like receptor 2 is associated with colorectal cancer

31 March 2020

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Functional variant in the 3'-untranslated region of Toll-like receptor 4 is associated with nasopharyngeal carcinoma risk

31 March 2020

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A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors.

31 March 2020

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Toll-like receptor 2 -196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer

31 March 2020

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Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma

31 March 2020

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Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice

31 March 2020

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12 December 2020

Heterozygous Thr 135 Ala polymorphism at leucine-rich repeat (LRR) in genomic DNA of toll-like receptor 4 in patients with poorly-differentiated gastric adenocarcinomas.

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12 December 2020

Essential requirement of toll-like receptor 4 expression on CD11c+ cells for locoregional immunotherapy of malignant ascites using a streptococcal preparation OK-432.

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12 December 2020

Studies on the Anticancer and Streptolysin S-Forming Abilities of Hemolytic Streptococci

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12 December 2020

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

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12 December 2020

The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893.

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12 December 2020

Identifiers

DOI

10.1038/NRC2541

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Dimensions Publication ID

19 August 2017

1016172523

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