(Q37769918)

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Arrhythmogenic liability screening in cardiovascular safety pharmacology: commonality between non-clinical safety pharmacology and clinical thorough QT (TQT) studies.

scientific article published on 19 June 2010

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7 February 2020

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Europe PubMed Central

Arrhythmogenic liability screening in cardiovascular safety pharmacology: commonality between non-clinical safety pharmacology and clinical thorough QT (TQT) studies (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601020%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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7 February 2020

Michael J. Curtis

4

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7 February 2020

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Simon Authier

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7 February 2020

Michael K Pugsley

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7 February 2020

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19 June 2010

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7 February 2020

Journal of Pharmacological and Toxicological Methods

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7 February 2020

62

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7 February 2020

2

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7 February 2020

83-88

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7 February 2020

Improvements in atrial fibrillation detection for real-time monitoring.

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Spontaneous cardiac arrhythmias recorded in three experimentally- and drug-naive laboratory species (canine, primate, swine) during standard pre-study screening

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Comparison of electrocardiographic analysis for risk of QT interval prolongation using safety pharmacology and toxicological studies

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Reference values of electrocardiogram repolarization variables in a healthy population.

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Non-drug-related electrocardiographic features in animal models in safety pharmacology

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How many ECG leads are required for in vivo studies in safety pharmacology?

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How many cardiac cycles must be measured to permit accurate RR, QT, and QTc estimates in conscious dogs?

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Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study

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First report of supraventricular tachycardia after intravenous pulse methylprednisolone therapy, with a brief review of the literature

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Thorough QT Studies: Questions and Quandaries

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Sample size, power calculations, and their implications for the cost of thorough studies of drug induced QT interval prolongation

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Use of ambulatory electrocardiography for detection of ventricular premature complexes in healthy dogs

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Proarrhythmia as a class effect of quinolones: increased dispersion of repolarization and triangulation of action potential predict torsades de pointes

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Effects of moxifloxacin on QT interval in conscious dogs

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Gender differences in autonomic modulation of ventricular repolarization in humans

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Gender differences in the effect of auditory stimuli on ventricular repolarization in healthy subjects

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Non-invasive telemetric electrocardiogram assessment in conscious beagle dogs.

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