(Q37774138)

23 August 2017

1 reference

title

Revealing the structural basis of action of hERG potassium channel activators and blockers (English)

1 reference

23 August 2017

Matthew Perry

1

1 reference

23 August 2017

Michael Sanguinetti

series ordinal

2

1 reference

23 August 2017

John Mitcheson

series ordinal

3

1 reference

23 August 2017

language of work or name

English

0 references

publication date

19 July 2010

1 reference

23 August 2017

published in

Journal of Physiology

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23 August 2017

volume

588

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23 August 2017

issue

Pt 17

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23 August 2017

page(s)

3157-3167

1 reference

Use-dependent block and use-dependent unblock of the delayed rectifier K+ current by almokalant in rabbit ventricular myocytes.

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Mechanism of action of a novel human ether-a-go-go-related gene channel activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Physicochemical features of the HERG channel drug binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Molecular determinants of dofetilide block of HERG K+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574).

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

hERG1 channel activators: a new anti-arrhythmic principle

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Mutational analysis of block and facilitation of HERG current by a class III anti-arrhythmic agent, nifekalant

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Docking model of drug binding to the human ether-à-go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Dynamic conformational changes of extracellular S5-P linkers in the hERG channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

The open pore conformation of potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Molecular determinants of HERG channel block.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Molecular determinants of hERG channel block by terfenadine and cisapride

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Gating of shaker-type channels requires the flexibility of S6 caused by prolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Structural and functional role of the extracellular s5-p linker in the HERG potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

A structural basis for drug-induced long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Topological mapping of the asymmetric drug binding to the human ether-à-go-go-related gene product (HERG) potassium channel by use of tandem dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Structural determinants of HERG channel block by clofilium and ibutilide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Gating currents associated with intramembrane charge displacement in HERG potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Lidoflazine is a high affinity blocker of the HERG K(+)channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Mechanisms and management of proarrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Voltage-Dependent Profile of HumanEther-a-go-go-Related Gene Channel Block Is Influenced by a Single Residue in the S6 Transmembrane Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

The inward rectification mechanism of the HERG cardiac potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Fast and slow voltage sensor movements in HERG potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Fast inactivation causes rectification of the IKr channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

State dependent dissociation of HERG channel inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Electrophysiologic characterization of a novel hERG channel activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Towards a structural view of gating in potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic aci

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

Gating charges in the activation and inactivation processes of the HERG channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.194670

HERG channel trafficking.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2976011

Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2976011

Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2976011

Open channel block of HERG K(+) channels by vesnarinone.

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2976011

Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites.

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2976011

Use-dependent 'agonist' effect of azimilide on the HERG channel.

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2976011

10.1113/JPHYSIOL.2010.194670

5 November 2018

Identifiers

DOI

1 reference

23 August 2017

0 references

1 reference