(Q42630920)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17823114%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

title

Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges (English)

1 reference

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6 January 2020

2

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6 January 2020

Mike Sutcliffe

4

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6 January 2020

John S Mitcheson

5

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6 January 2020

author name string

Rachael M Hardman

1

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6 January 2020

Sarah Dalibalta

3

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6 January 2020

language of work or name

English

0 references

publication date

6 September 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17823114%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

6 January 2020

published in

1 reference

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6 January 2020

volume

282

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6 January 2020

issue

44

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6 January 2020

page(s)

31972-31981

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Expression and Role of hERG Channels in Cancer Cells

6 January 2020

cites work

1 reference

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hERG potassium channels and cardiac arrhythmia

21 January 2018

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QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development

21 January 2018

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Predicting drug-hERG channel interactions that cause acquired long QT syndrome.

21 January 2018

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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

21 January 2018

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Crystal structure of the potassium channel KirBac1.1 in the closed state

21 January 2018

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The open pore conformation of potassium channels

21 January 2018

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Crystal structure and mechanism of a calcium-gated potassium channel

21 January 2018

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X-ray structure of a voltage-dependent K+ channel

21 January 2018

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Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

21 January 2018

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Conformational dynamics of helix S6 from Shaker potassium channel: simulation studies.

21 January 2018

1 reference

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Stereochemical quality of protein structure coordinates

21 January 2018

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Conserved gating hinge in ligand- and voltage-dependent K+ channels

21 January 2018

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Investigating the putative glycine hinge in Shaker potassium channel.

21 January 2018

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A gating hinge in Na+ channels; a molecular switch for electrical signaling

21 January 2018

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Proline-induced distortions of transmembrane helices.

21 January 2018

1 reference

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Structure and dynamics of K channel pore-lining helices: a comparative simulation study

21 January 2018

1 reference

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Gating of shaker-type channels requires the flexibility of S6 caused by prolines

21 January 2018

1 reference

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Sequence-Function Analysis of the K+-Selective Family of Ion Channels Using a Comprehensive Alignment and the KcsA Channel Structure

21 January 2018

1 reference

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Helix geometry in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Effect of alanine versus glycine in alpha-helices on protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment

21 January 2018

1 reference

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A structural basis for drug-induced long QT syndrome

21 January 2018

1 reference

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Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Structural determinants of HERG channel block by clofilium and ibutilide.

21 January 2018

1 reference

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Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

21 January 2018

The Protein Data Bank

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Setting up and optimization of membrane protein simulations.

21 January 2018

1 reference

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Detection, delineation, measurement and display of cavities in macromolecular structures

21 January 2018

1 reference

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Ion permeation mechanism of the potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

GROMACS: fast, flexible, and free

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Conformational dynamics of M2 helices in KirBac channels: helix flexibility in relation to gating via molecular dynamics simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Differential roles of S6 domain hinges in the gating of KCNQ potassium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

The Selectivity Filter May Act as the Agonist-activated Gate in the G Protein-activated Kir3.1/Kir3.4 K+ Channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Helical packing patterns in membrane and soluble proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

A mutation data matrix for transmembrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

21 January 2018

1 reference

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The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment

21 January 2018

1 reference

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Status of the intracellular gate in the activated-not-open state of shaker K+ channels

21 January 2018

1 reference

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New roles for a key glycine and its neighboring residue in potassium channel gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

The S4-S5 linker couples voltage sensing and activation of pacemaker channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Protein volume in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

Molecular dynamics with coupling to an external bath

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705835200

21 January 2018

Identifiers

DOI

10.1074/JBC.M705835200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17823114%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference