(Q37777696)

23 August 2017

1 reference

title

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites (English)

1 reference

23 August 2017

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites (English)

1 reference

16 June 2024

0 references

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20683968

16 June 2024

author name string

Brent A. Neuschwander-Tetri

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20683968

16 June 2024

language of work or name

English

0 references

publication date

1 August 2010

1 reference

full work available at URL

23 August 2017

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.23719

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20683968

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.23719

16 June 2024

1 reference

https://onlinelibrary.wiley.com/doi/full/10.1002/hep.23719

16 June 2024

1 reference

16 June 2024

1 reference

23 August 2017

volume

52

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23 August 2017

issue

2

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23 August 2017

page(s)

774-788

1 reference

Steatohepatitis: a tale of two "hits"?

23 August 2017

cites work

1 reference

7 January 2021

Hepatic steatosis: innocent bystander or guilty party?

1 reference

7 January 2021

Hepatic triglyceride synthesis and nonalcoholic fatty liver disease

1 reference

7 January 2021

Mechanisms of disease progression in nonalcoholic fatty liver disease

1 reference

7 January 2021

Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors

1 reference

7 January 2021

Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients

1 reference

7 January 2021

Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis

1 reference

7 January 2021

Abnormalities of lipid metabolism in nonalcoholic fatty liver disease

1 reference

7 January 2021

Role of insulin resistance and lipotoxicity in non-alcoholic steatohepatitis

1 reference

7 January 2021

Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it?

1 reference

7 January 2021

Saturated with fat: new perspectives on lipotoxicity

1 reference

7 January 2021

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

1 reference

7 January 2021

Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease

1 reference

7 January 2021

Bioactive lipids in metabolic syndrome

1 reference

7 January 2021

Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis

1 reference

7 January 2021

A lipidomic analysis of nonalcoholic fatty liver disease.

1 reference

7 January 2021

In situ lipidomic analysis of nonalcoholic fatty liver by cluster TOF-SIMS imaging

1 reference

7 January 2021

Shotgun lipidomics of neutral lipids as an enabling technology for elucidation of lipid-related diseases

1 reference

7 January 2021

Hepatic triacylglycerol accumulation and insulin resistance.

1 reference

7 January 2021

The plasma lipidomic signature of nonalcoholic steatohepatitis

1 reference

7 January 2021

Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.

1 reference

7 January 2021

Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase

1 reference

7 January 2021

Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors

1 reference

7 January 2021

The pathogenesis of nonalcoholic steatohepatitis and other fatty liver diseases: a four-step model including the role of lipid release and hepatic venular obstruction in the progression to cirrhosis

1 reference

7 January 2021

Lipidomic dissection of nonalcoholic steatohepatitis: moving beyond foie gras to fat traffic

1 reference

7 January 2021

Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease

1 reference

7 January 2021

Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

1 reference

7 January 2021

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

1 reference

7 January 2021

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

1 reference

7 January 2021

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

1 reference

7 January 2021

Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

1 reference

7 January 2021

Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER.

1 reference

7 January 2021

Insulin sensitivity: modulation by nutrients and inflammation

1 reference

7 January 2021

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

1 reference

7 January 2021

Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the beta-cell line INS-1

1 reference

7 January 2021

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

1 reference

7 January 2021

Lipotoxicity: when tissues overeat

1 reference

7 January 2021

Splanchnic lipolysis in human obesity

1 reference

7 January 2021

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

1 reference

7 January 2021

Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins

1 reference

7 January 2021

Lipid metabolism in hepatic steatosis

1 reference

7 January 2021

Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy

1 reference

7 January 2021

Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis

1 reference

7 January 2021

Decreased Hepatic Triglyceride Accumulation and Altered Fatty Acid Uptake in Mice with Deletion of the Liver Fatty Acid-binding Protein Gene

1 reference

7 January 2021

Differential expression of lumican and fatty acid binding protein-1: new insights into the histologic spectrum of nonalcoholic fatty liver disease

1 reference

7 January 2021

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome

1 reference

7 January 2021

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice.

1 reference

7 January 2021

Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway

1 reference

7 January 2021

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

1 reference

7 January 2021

Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes

1 reference

7 January 2021

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

1 reference

7 January 2021

Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome

1 reference

7 January 2021

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

1 reference

7 January 2021

Positively charged ceramide is a potent inducer of mitochondrial permeabilization.

1 reference

7 January 2021

Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

1 reference

7 January 2021

Palmitate-induced apoptosis can occur through a ceramide-independent pathway

1 reference

7 January 2021

Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism

1 reference

7 January 2021

Lipid accumulation in non-adipose tissue and lipotoxicity

1 reference

7 January 2021

Lysophosphatidylcholine activates a novel PKD2-mediated signaling pathway that controls monocyte migration

1 reference

7 January 2021

Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD).

1 reference

7 January 2021

Autophagy regulates lipid metabolism

1 reference

7 January 2021

Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities

1 reference

7 January 2021

Adipocyte metabolism and obesity

1 reference

7 January 2021

Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis

1 reference

7 January 2021

Regulation of lipolysis in adipocytes

1 reference

7 January 2021

PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.

1 reference

7 January 2021

Location, location: protein trafficking and lipolysis in adipocytes

1 reference

7 January 2021

Advances in adipose tissue metabolism

1 reference

7 January 2021

Lipolysis control: the plot thickens.

1 reference

7 January 2021

Glycerolipid metabolism and signaling in health and disease

1 reference

7 January 2021

The skinny on fat: lipolysis and fatty acid utilization in adipocytes

1 reference

7 January 2021

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

1 reference

7 January 2021

Metabolism: bile acids heat things up

1 reference

7 January 2021

The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans

1 reference

7 January 2021

Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease.

1 reference

7 January 2021

Liver morphology and function tests in obesity and during total starvation

1 reference

7 January 2021

Fasting in obesity: another cause of liver injury with alcoholic hyaline?

1 reference

7 January 2021

Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues

1 reference

7 January 2021

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

1 reference

7 January 2021

Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice

1 reference

7 January 2021

Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men.

1 reference

7 January 2021

Fructose consumption as a risk factor for non-alcoholic fatty liver disease

1 reference

7 January 2021

A sweet path to insulin resistance through PGC-1beta

1 reference

7 January 2021

Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis

1 reference

7 January 2021

Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease

1 reference

7 January 2021

Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet

1 reference

7 January 2021

Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity

1 reference

7 January 2021

Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.

1 reference

7 January 2021

Fructose-induced hepatic gluconeogenesis: effect of L-carnitine.

1 reference

7 January 2021

Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance

1 reference

7 January 2021

Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis

1 reference

7 January 2021

SREBPs: physiology and pathophysiology of the SREBP family

1 reference

7 January 2021

The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis

1 reference

7 January 2021

FXR: a metabolic regulator and cell protector

1 reference

7 January 2021

Cell biology: Another way to get rid of fat.

1 reference

7 January 2021

Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways

1 reference

7 January 2021

Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet

1 reference

7 January 2021

Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients.

1 reference

7 January 2021

Augmented resistance to oxidative stress in fatty rat livers induced by a short-term sucrose-rich diet.

1 reference

7 January 2021

Increase in liver antioxidant enzyme activities in non-alcoholic fatty liver disease

1 reference

7 January 2021

Role of fatty acids in the pathogenesis of obesity and fatty liver: impact of bariatric surgery

1 reference

7 January 2021

Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis

1 reference

7 January 2021

Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation.

1 reference

7 January 2021

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

1 reference

7 January 2021

Mitochondria in nonalcoholic fatty liver disease

1 reference

7 January 2021

Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance

1 reference

7 January 2021

Acute hepatic steatosis in mice by blocking beta-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production

1 reference

7 January 2021

Role of mitochondria in non-alcoholic fatty liver disease

1 reference

7 January 2021

Cardiovascular risk factors emerge after artificial selection for low aerobic capacity

1 reference

7 January 2021

Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury

1 reference

7 January 2021

Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism

1 reference

7 January 2021

Three for the price of one knockout--a mouse model of a congenital peroxisomal disorder, steatohepatitis, and hepatocarcinogenesis.

1 reference

7 January 2021

Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice

1 reference

7 January 2021

NASH--hepatic metabolism and not simply the metabolic syndrome

1 reference

7 January 2021

Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice.

1 reference

7 January 2021

Bezafibrate for tamoxifen-induced non-alcoholic steatohepatitis

1 reference

7 January 2021

Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system

1 reference

7 January 2021

Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease.

1 reference

7 January 2021

Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases

1 reference

7 January 2021

Lipid droplets in lipogenesis and lipolysis

1 reference

7 January 2021

Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance

1 reference

7 January 2021

Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury.

1 reference

7 January 2021

Inhibition of stearoyl CoA desaturase activity induces hypercholesterolemia in the cholesterol-fed hamster

1 reference

7 January 2021

Liver pathology and the metabolic syndrome X in severe obesity.

1 reference

7 January 2021

Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese

1 reference

7 January 2021

Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association

1 reference

7 January 2021

Metabolic and anthropometric evaluation of insulin resistance in nondiabetic patients with nonalcoholic steatohepatitis

1 reference

7 January 2021

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

1 reference

7 January 2021

Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis

1 reference

7 January 2021

Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis

1 reference

7 January 2021

A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis

1 reference

7 January 2021

PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization

1 reference

7 January 2021

Hypoglycemic action of thiazolidinediones/peroxisome proliferator-activated receptor gamma by inhibition of the c-Jun NH2-terminal kinase pathway

1 reference

7 January 2021

Repeatability characteristics of simple indices of insulin resistance: implications for research applications

1 reference

7 January 2021

Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal models

1 reference

7 January 2021

Disordered lipid metabolism and the pathogenesis of insulin resistance

1 reference

7 January 2021

Fatty liver in familial hypobetalipoproteinemia: triglyceride assembly into VLDL particles is affected by the extent of hepatic steatosis.

1 reference

7 January 2021

Preserved direct hepatic insulin action in rats with diet-induced hepatic steatosis

1 reference

7 January 2021

Review article: hepatic steatosis and insulin resistance

1 reference

7 January 2021

Hepatic steatosis and insulin resistance: does etiology make a difference?

1 reference

7 January 2021

Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance.

1 reference

7 January 2021

Abnormal hepatic energy homeostasis in type 2 diabetes

1 reference

7 January 2021

Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury

1 reference

7 January 2021

Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice

1 reference

7 January 2021

The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress

1 reference

7 January 2021

Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers

1 reference

7 January 2021

Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase

1 reference

7 January 2021

Reactive oxygen species enhance insulin sensitivity

1 reference

7 January 2021

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

1 reference

7 January 2021

Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis

1 reference

7 January 2021

Identification of genes that regulate multiple cellular processes/responses in the context of lipotoxicity to hepatoma cells

1 reference

7 January 2021

The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer

1 reference

7 January 2021

Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.

1 reference

7 January 2021

Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study

1 reference

7 January 2021

Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver

1 reference

7 January 2021

Reduced inflammatory response and increased microcirculatory disturbances during hepatic ischemia-reperfusion injury in steatotic livers of ob/ob mice

1 reference

7 January 2021

Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity

1 reference

7 January 2021

Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation

1 reference

7 January 2021

Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease

1 reference

7 January 2021

Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH.

1 reference

7 January 2021

Adipokines in liver diseases

1 reference

7 January 2021

Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease

1 reference

7 January 2021

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis

1 reference

7 January 2021

Enlarged hepatocytes in NAFLD examined with osmium fixation: does microsteatosis underlie cellular ballooning in NASH?

1 reference

7 January 2021

Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects

1 reference

7 January 2021

Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent

1 reference

7 January 2021

Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease

1 reference

7 January 2021

Hepatotoxicity of fast food?

1 reference

7 January 2021

Hepatic steatosis rather than visceral adiposity is more closely associated with insulin resistance in the early stage of obesity

1 reference

7 January 2021

Relationship among histologic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver samples

1 reference

7 January 2021

Values and limitations of serum aminotransferases in clinical trials of nonalcoholic steatohepatitis

1 reference

7 January 2021

1 reference

7 January 2021

Variation in the adiponutrin gene influences its expression and associates with obesity.

1 reference

7 January 2021

Inherited susceptibility to non-alcoholic fatty liver disease.

1 reference

7 January 2021

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

1 reference

7 January 2021

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

1 reference

7 January 2021

A1 adenosine receptor: role in diabetes and obesity

1 reference

7 January 2021

Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis

1 reference

7 January 2021

Physiological Effect of Glucagon in Human Isolated Adipocytes

1 reference

7 January 2021

Metabolic effects of caffeine in humans: lipid oxidation or futile cycling?

1 reference

7 January 2021

Control of lipolysis by natriuretic peptides and cyclic GMP.

1 reference

7 January 2021

Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes

1 reference

7 January 2021

Chanarin-Dorfman syndrome: deficiency in CGI-58, a lipid droplet-bound coactivator of lipase

1 reference

7 January 2021

Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis

1 reference

7 January 2021

Considerations on the pathogenesis of fatty liver

61

1 reference

The significance of differences in fatty acid metabolism between obese and non-obese patients with non-alcoholic fatty liver disease

16 June 2024

123

1 reference

Fatty liver and insulin resistance: not always linked

16 June 2024

129

1 reference

Hepatic ATP reserve and efficiency of replenishing: comparison between obese and nonobese normal individuals

16 June 2024

164

1 reference

16 June 2024

Identifiers

DOI

10.1002/HEP.23719

1 reference

23 August 2017

1 reference