(Q37282312)

19 August 2017

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title

FXR: a metabolic regulator and cell protector (English)

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19 August 2017

Yan-Dong Wang

1

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19 August 2017

Wei-Dong Chen

series ordinal

2

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19 August 2017

David D Moore

series ordinal

3

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19 August 2017

Wendong Huang

series ordinal

4

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19 August 2017

1 November 2008

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19 August 2017

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19 August 2017

18

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19 August 2017

1087-1095

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19 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/cr.2008.289

19 August 2017

0 references

cites work

The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

Pre-replicative phase-related changes in bile acid-induced choleresis in the regenerating rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

Bile acid regulation of hepatic physiology: IV. Bile acids and death receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

Nuclear receptors and lipid physiology: opening the X-files

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Identification of a nuclear receptor that is activated by farnesol metabolites

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Expression and activation of the farnesoid X receptor in the vasculature

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

https://api.crossref.org/works/10.1038%2FCR.2008.289

1 reference

7 January 2021

The nuclear receptor superfamily: the second decade

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

FXR signaling in metabolic disease

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Identification of a nuclear receptor for bile acids

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Bile acids: natural ligands for an orphan nuclear receptor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Identification of gene-selective modulators of the bile acid receptor FXR.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Identification of a chemical tool for the orphan nuclear receptor FXR.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR).

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Structural basis for bile acid binding and activation of the nuclear receptor FXR

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Nuclear bile acid receptor FXR as pharmacological target: are we there yet?

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

FXR: a promising target for the metabolic syndrome?

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

FXR, a multipurpose nuclear receptor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Regulation of complement C3 expression by the bile acid receptor FXR.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Irregular regeneration of hepatocytes and risk of hepatocellular carcinoma in chronic hepatitis and cirrhosis with hepatitis-C-virus infection

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Regulation of hepatic Insig-2 by the farnesoid X receptor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

The farnesoid X receptor induces very low density lipoprotein receptor gene expression

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Regulation of carbohydrate metabolism by the farnesoid X receptor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Farnesoid X receptor is essential for normal glucose homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Bacterial translocation from the gastrointestinal tract

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

The role of bile and bile acids in bacterial translocation in obstructive jaundice in rats

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

https://api.crossref.org/works/10.1038%2FCR.2008.289

1 reference

7 January 2021

Irregular regeneration of hepatocytes is an important factor in the hepatocarcinogenesis of liver disease.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Liver function in regenerating rat liver. CrPO4 colloid uptake and bile flow

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Bile acid secretion during synchronized rat liver regeneration1This study was supported in part by grants SAF94-0693 and SAF96-0146 from the Comision Interministerial Cientifica y Tecnica and grants SA21/96 and SA19/97 from the Junta de Castilla y Le

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Iron and hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Prevalence of hepatocellular carcinoma in alpha-1-antitrypsin deficiency

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Nuclear factor-kappaB in cancer development and progression

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Glycogen storage disease I and hepatocellular tumours

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Wilson's disease and hepatocellular carcinoma: possible protective role of copper

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Influence of ursodeoxycholate-enriched diet on liver tumor growth in HBV transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Plasma deoxycholic acid concentration is elevated in postmenopausal women with newly diagnosed breast cancer.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.289

7 January 2021

Identifiers

DOI

10.1038/CR.2008.289

1 reference

19 August 2017

1 reference