(Q37778403)

23 August 2017

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title

Leptin gene therapy in the fight against diabetes (English)

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23 August 2017

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Yuqing Wang

1

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23 August 2017

Akihiro Asakawa

2

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23 August 2017

Akio Inui

3

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23 August 2017

Ken-ichiro Kosai

4

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23 August 2017

language of work or name

English

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publication date

1 October 2010

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full work available at URL

23 August 2017

http://www.informapharmascience.com/doi/abs/10.1517/14712598.2010.512286

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20690892

http://www.tandfonline.com/doi/pdf/10.1517/14712598.2010.512286

17 June 2024

1 reference

https://api.crossref.org/works/10.1517/14712598.2010.512286

Expert Opinion on Biological Therapy

17 June 2024

published in

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23 August 2017

volume

10

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23 August 2017

issue

10

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23 August 2017

page(s)

1405-1414

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Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk

23 August 2017

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Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions

21 January 2018

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Leptin and the regulation of body weight in mammals

21 January 2018

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Interacting appetite-regulating pathways in the hypothalamic regulation of body weight

21 January 2018

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Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: new therapeutic approaches

21 January 2018

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Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight

21 January 2018

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High-fat diet-induced ultradian leptin and insulin hypersecretion are absent in obesity-resistant rats.

21 January 2018

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Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Central LIF gene therapy suppresses food intake, body weight, serum leptin and insulin for extended periods

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2010.512286

New drug targets for type 2 diabetes and the metabolic syndrome

21 January 2018

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Type 2 diabetes: where we are today: an overview of disease burden, current treatments, and treatment strategies

21 January 2018

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Immunotherapy of type 1 diabetes: where are we and where should we be going?

21 January 2018

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Insulins today and beyond

21 January 2018

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Diabetes. Paradoxical effects of tightly controlled blood sugar

21 January 2018

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Mechanisms linking obesity to insulin resistance and type 2 diabetes

21 January 2018

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Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Positional cloning of the mouse obese gene and its human homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Weight-reducing effects of the plasma protein encoded by the obese gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

The role of leptin in human obesity and disease: a review of current evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

The stomach is a source of leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Divergent signaling capacities of the long and short isoforms of the leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Identification and expression cloning of a leptin receptor, OB-R

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Congenital leptin deficiency is associated with severe early-onset obesity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

AAV-mediated leptin receptor installation improves energy balance and the reproductive status of obese female Koletsky rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Transient increase in obese gene expression after food intake or insulin administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Effects of the obese gene product on body weight regulation in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Mechanism of glucoregulatory responses to stress and their deficiency in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

21 January 2018

The metabolic syndrome

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Circumventing leptin resistance for weight control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Molecular regulation of adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

From preadipocyte to adipocyte: differentiation-directed signals of insulin from the cell surface to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

The development of gene therapy: from monogenic recessive disorders to complex diseases such as cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Gene therapy: adenovirus vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

In vivo hepatic HB-EGF gene transduction inhibits Fas-induced liver injury and induces liver regeneration in mice: a comparative study to HGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Local overexpression of HB-EGF exacerbates remodeling following myocardial infarction by activating noncardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Diffuse encephaloventriculitis and substantial leukoencephalopathy after intraventricular administration of recombinant adenovirus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Identification and isolation of embryonic stem cell-derived target cells by adenoviral conditional targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Production of adenovirus vector for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Designing adenoviral vectors for tumor-specific targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Survivin-responsive conditionally replicating adenovirus exhibits cancer-specific and efficient viral replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

An efficient construction of conditionally replicating adenoviruses that target tumor cells with multiple factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Recombinant adeno-associated virus transduction and integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Recombinant adeno-associated virus for muscle directed gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Long-term gene transfer in porcine myocardium after coronary infusion of an adeno-associated virus vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Analysis of adeno-associated virus progenitor cell transduction in mouse lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Clinical gene therapy using recombinant adeno-associated virus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Retrovirus-mediated in vivo gene transfer in the replicating liver using recombinant hepatocyte growth factor without liver injury or partial hepatectomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

A definitive role of RhoC in metastasis of orthotopic lung cancer in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Correction of obesity and diabetes in genetically obese mice by leptin gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Stem cell therapy for type 1 diabetes mellitus: a review of recent clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Diet-induced obese mice develop peripheral, but not central, resistance to leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Molecular and anatomical determinants of central leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Suppression of fat deposition for the life time with gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Gene-transfer technology: a preventive neurotherapy to curb obesity, ameliorate metabolic syndrome and extend life expectancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Ten years of gene therapy for primary immune deficiencies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

A death in the laboratory: the politics of the Gelsinger aftermath

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Investigation of the cause of death in a gene-therapy trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Acute stimulation of glucose metabolism in mice by leptin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.512286

Obesity and metabolic syndrome: long-term benefits of central leptin gene therapy.

21 January 2018

14

1 reference

https://api.crossref.org/works/10.1517/14712598.2010.512286

Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans

17 June 2024

25

1 reference

https://api.crossref.org/works/10.1517/14712598.2010.512286

The adipoinsular axis: effects of leptin on pancreatic beta-cells

17 June 2024

46

1 reference

https://api.crossref.org/works/10.1517/14712598.2010.512286

Hepatocyte growth factor gene therapy slows down the progression of diabetic nephropathy in db/db mice

17 June 2024

54

1 reference

https://api.crossref.org/works/10.1517/14712598.2010.512286

Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector

17 June 2024

72

1 reference

https://api.crossref.org/works/10.1517/14712598.2010.512286

The endocrine function of adipose tissue: an update

17 June 2024

82

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https://api.crossref.org/works/10.1517/14712598.2010.512286

Clinical trials. Gene transfer an unlikely contributor to patient's death

17 June 2024

97

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https://api.crossref.org/works/10.1517/14712598.2010.512286

17 June 2024

Identifiers

1 reference

23 August 2017

1 reference