(Q37778758)

23 August 2017

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title

The potential of cytokines as safety biomarkers for drug-induced liver injury (English)

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23 August 2017

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Hugh G Laverty

1

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23 August 2017

Daniel J Antoine

2

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23 August 2017

Craig Benson

3

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23 August 2017

Masautso Chaponda

4

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23 August 2017

Dominic Williams

5

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23 August 2017

B Kevin Park

6

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23 August 2017

6 August 2010

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European Journal of Clinical Pharmacology

23 August 2017

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23 August 2017

66

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23 August 2017

961-976

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23 August 2017

10

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https://scigraph.springernature.com/pub.10.1007/s00228-010-0862-x

23 August 2017

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cites work

Accuracy of hepatic adverse drug reaction reporting in one English health region

1 reference

https://api.crossref.org/works/10.1007%2FS00228-010-0862-X

Why patients choose paracetamol for self poisoning and their knowledge of its dangers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-010-0862-X

Detailed analysis of intrahepatic CD8 T cells in the normal and hepatitis C-infected liver reveals differences in specific populations of memory cells with distinct homing phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-010-0862-X

Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-010-0862-X

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-010-0862-X

ERK1/2 and Egr-1 contribute to increased TNF-alpha production in rat Kupffer cells after chronic ethanol feeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-010-0862-X

Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-010-0862-X

Effects of acute liver injury on blood coagulation

21 January 2018

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12 December 2020

Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production

1 reference

12 December 2020

Acute alcohol produces hypoxia directly in rat liver tissue in vivo: role of Kupffer cells

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12 December 2020

Neutrophilic infiltration in alcoholic hepatitis

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12 December 2020

Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents

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12 December 2020

Signalling pathways in alcohol-induced liver inflammation.

1 reference

12 December 2020

Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C

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12 December 2020

Implication of Th17 and Th1 cells in patients with chronic active hepatitis B.

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12 December 2020

Cytokines and toxicity in acetaminophen overdose

1 reference

12 December 2020

Cytokine and chemokine expression associated with steatohepatitis and hepatocyte proliferation in rats fed ethanol via total enteral nutrition

1 reference

12 December 2020

Early growth response-1 transcription factor is essential for ethanol-induced fatty liver injury in mice.

1 reference

12 December 2020

Role of osteopontin in regulating hepatic inflammatory responses and toxic liver injury

1 reference

12 December 2020

Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9

1 reference

12 December 2020

Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity

1 reference

12 December 2020

The current state of serum biomarkers of hepatotoxicity.

1 reference

12 December 2020

Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocyte chemoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulation

1 reference

12 December 2020

Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease

1 reference

12 December 2020

IP-10 predicts viral response and therapeutic outcome in difficult-to-treat patients with HCV genotype 1 infection

1 reference

12 December 2020

Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen.

1 reference

12 December 2020

Serum leptin in patients with alcoholic liver disease

1 reference

12 December 2020

Timing of new black box warnings and withdrawals for prescription medications

1 reference

12 December 2020

The interleukin-17 pathway is involved in human alcoholic liver disease

1 reference

12 December 2020

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism

1 reference

12 December 2020

Recent insights into the role of the innate immune system in the development of alcoholic liver disease.

1 reference

12 December 2020

LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor

1 reference

12 December 2020

Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy

1 reference

12 December 2020

Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity

1 reference

12 December 2020

Chronic alcoholism is associated with an imbalanced production of Th-1/Th-2 cytokines by peripheral blood T cells

1 reference

12 December 2020

Mechanism-based bioanalysis and biomarkers for hepatic chemical stress.

1 reference

12 December 2020

Update on autoimmune hepatitis

1 reference

12 December 2020

Strain difference in the induction of T-cell activation-associated, interferon gamma-dependent hepatic injury in mice

1 reference

12 December 2020

Cytokines in the liver

1 reference

12 December 2020

A novel migration pathway for rat dendritic cells from the blood: hepatic sinusoids-lymph translocation

1 reference

12 December 2020

Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.

1 reference

12 December 2020

Recent advances in alcoholic liver disease III. Role of the innate immune response in alcoholic hepatitis.

1 reference

12 December 2020

Phospholipid antibodies in alcoholic liver disease

1 reference

12 December 2020

Neutrophil depletion protects against murine acetaminophen hepatotoxicity

1 reference

12 December 2020

Immune Responses to Ethanol Metabolites and Cytokine Profiles Differentiate Alcoholics with or without Liver Disease

1 reference

12 December 2020

Chronic infections with hepatotropic viruses: mechanisms of impairment of cellular immune responses

1 reference

12 December 2020

Cytokine and autoantibody patterns in acute liver failure

1 reference

12 December 2020

Mechanisms of drug-induced liver injury.

1 reference

12 December 2020

Emergence of the Th17 pathway and its role in host defense.

1 reference

12 December 2020

Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis

1 reference

12 December 2020

Role of neutrophils in hepatotoxicity induced by oral acetaminophen administration in rats

1 reference

12 December 2020

Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity

1 reference

12 December 2020

Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice

1 reference

12 December 2020

Toxicological consequences of altered peroxisome proliferator-activated receptor gamma (PPARgamma) expression in the liver: insights from models of obesity and type 2 diabetes

1 reference

12 December 2020

Concordance of the toxicity of pharmaceuticals in humans and in animals

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12 December 2020

Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity.

1 reference

12 December 2020

Biomarker method validation in anticancer drug development

1 reference

12 December 2020

Innate immune response and hepatic inflammation

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12 December 2020

Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice

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12 December 2020

How relevant are neutrophils for acetaminophen hepatotoxicity?

1 reference

12 December 2020

Using controlled clinical trials to learn more about acute drug-induced liver injury

1 reference

12 December 2020

Interactions of dihydralazine with cytochromes P4501A: a possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies

1 reference

12 December 2020

Leukocyte alterations do not account for hepatitis induced by endotoxin or TNF alpha in galactosamine-sensitized mice.

1 reference

12 December 2020

Blockade of the receptor for advanced glycation end products attenuates acetaminophen-induced hepatotoxicity in mice

1 reference

12 December 2020

Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease

1 reference

12 December 2020

Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines

1 reference

12 December 2020

Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids

1 reference

12 December 2020

Recent advances in viral hepatitis

1 reference

12 December 2020

Adipocytokines: mediators linking adipose tissue, inflammation and immunity

1 reference

12 December 2020

Hepatoprotective role of endogenous interleukin-13 in a murine model of acetaminophen-induced liver disease

1 reference

12 December 2020

Cellular imaging predictions of clinical drug-induced liver injury

1 reference

12 December 2020

A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury.

1 reference

12 December 2020

Macrophage migration inhibitory factor in drug-induced liver injury: a role in susceptibility and stress responsiveness

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12 December 2020

Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity

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12 December 2020

Enhancing the utility of alanine aminotransferase as a reference standard biomarker for drug-induced liver injury

1 reference

12 December 2020

Biomarker qualification pilot process at the US Food and Drug Administration

1 reference

12 December 2020

N-acetylcysteine pretreatment decreases cocaine and endotoxin-induced hepatotoxicity

1 reference

12 December 2020

Cytokines as potential biomarkers of liver toxicity

1 reference

12 December 2020

Involvement of chemokines and type 1 cytokines in the pathogenesis of hepatitis C virus-associated mixed cryoglobulinemia vasculitis neuropathy

1 reference

12 December 2020

Adipokines as emerging mediators of immune response and inflammation.

1 reference

12 December 2020

Neutrophil depletion protects against liver injury from bacterial endotoxin

1 reference

12 December 2020

Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation

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12 December 2020

Histopathology of acetaminophen-induced liver changes: role of interleukin 1 alpha and tumor necrosis factor alpha

1 reference

12 December 2020

Endotoxemia and gut barrier dysfunction in alcoholic liver disease

1 reference

12 December 2020

Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production

1 reference

12 December 2020

Differential role of ethanol and acetaldehyde in the induction of oxidative stress in HEP G2 cells: effect on transcription factors AP-1 and NF-kappaB

1 reference

12 December 2020

Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver

1 reference

12 December 2020

Use of pharmaco-metabonomics for early prediction of acetaminophen-induced hepatotoxicity in humans

1 reference

12 December 2020

Noncytolytic control of viral infections by the innate and adaptive immune response

1 reference

12 December 2020

Incidence of drug-induced hepatic injuries: a French population-based study

1 reference

12 December 2020

Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver

1 reference

12 December 2020

Cytokines and chemokines--their receptors and their genes: an overview.

1 reference

12 December 2020

A metabolite of halothane covalently binds to an endoplasmic reticulum protein that is highly homologous to phosphatidylinositol-specific phospholipase C-alpha but has no activity

1 reference

12 December 2020

High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo

1 reference

12 December 2020

The hepatic inflammatory response after acetaminophen overdose: role of neutrophils

1 reference

12 December 2020

Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1 Potential role of inflammatory mediators

1 reference

12 December 2020

Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches

1 reference

12 December 2020

Chemokines in the immunopathogenesis of hepatitis C infection

1 reference

12 December 2020

Alcohol and the liver

1 reference

12 December 2020

Immunology of hepatitis B virus and hepatitis C virus infection

1 reference

12 December 2020

Clinical immune characterization of hepatitis B virus infection and implications for immune intervention: Progress and challenges

1 reference

12 December 2020

Transcriptional activation of heme oxygenase-1 and its functional significance in acetaminophen-induced hepatitis and hepatocellular injury in the rat.

1 reference

12 December 2020

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.

1 reference

12 December 2020

Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure

1 reference

12 December 2020

Prolonged ethanol treatment enhances lipopolysaccharide/phorbol myristate acetate-induced tumor necrosis factor-alpha production in human monocytic cells

1 reference

12 December 2020

Endotoxin potentiates cocaine-mediated hepatotoxicity by nitric oxide and reactive oxygen species

1 reference

12 December 2020

Drug-related hepatotoxicity

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12 December 2020

Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury

1 reference

12 December 2020

Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10.

1 reference

12 December 2020

Incidence of drug-induced liver injury in medical inpatients.

1 reference

12 December 2020

Immunoallergic drug-induced hepatitis: lessons from halothane

1 reference

12 December 2020

Flying under the radar: the immunobiology of hepatitis C.

1 reference

12 December 2020

CCL3/MIP-1alpha is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4(+) T cells to the liver

1 reference

12 December 2020

The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice

1 reference

12 December 2020

Nonalcoholic fatty liver disease: a review and update

1 reference

12 December 2020

Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection

1 reference

12 December 2020

Inactivation of Kupffer cells prevents early alcohol-induced liver injury

1 reference

12 December 2020

Hapten carrier conjugates associated with halothane hepatitis

1 reference

12 December 2020

Interleukin-17 as a new marker of severity of acute hepatic injury

1 reference

12 December 2020

The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice

1 reference

12 December 2020

Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species

1 reference

12 December 2020

Down-regulation of tumor necrosis factor alpha activity by acute ethanol treatment in human peripheral blood monocytes

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12 December 2020

2. Cytokines and chemokines

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12 December 2020

Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients

1 reference

12 December 2020

Role of proinflammatory cytokines in acetaminophen hepatotoxicity

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12 December 2020

Influence of halothane on the interactions of serotonin1A and adenosine A1 receptors with G proteins in rat brain membranes.

1 reference

12 December 2020

The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes

1 reference

12 December 2020

The role of CCR5/CXCR3 expressing CD8+ cells in liver damage and viral control during persistent hepatitis C virus infection

1 reference

12 December 2020

Drug-induced hepatotoxicity.

1 reference

12 December 2020

Admission levels and early changes in serum interleukin-10 are predictive of poor outcome in acute liver failure and decompensated cirrhosis

1 reference

12 December 2020

Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine

1 reference

12 December 2020

Hyaluronic acid and endothelial damage due to paracetamol-induced hepatotoxicity

1 reference

12 December 2020

Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist.

1 reference

12 December 2020

Role of tumor necrosis factor receptor 1 (p55) in hepatocyte proliferation during acetaminophen-induced toxicity in mice

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12 December 2020

Inhibition of tumour necrosis factor alpha does not prevent experimental paracetamol-induced hepatic necrosis

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12 December 2020

Expansion of hepatitis C-specific CD4+CD25+ regulatory T cells after viral clearance: a mechanism to limit collateral damage?

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12 December 2020

The role of Kupffer cell oxidant production in early ethanol-induced liver disease.

1 reference

12 December 2020

Pentraxins, humoral innate immunity and tissue injury

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12 December 2020

Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide

1 reference

12 December 2020

Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin-alpha gene knockout mice

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12 December 2020

Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection

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12 December 2020

Th17 cells in human disease.

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12 December 2020

Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury

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12 December 2020

Dalteparin sodium prevents liver injury due to lipopolysaccharide in rat through suppression of tumor necrosis factor-alpha production by Kupffer cells

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12 December 2020

Cytokine and chemokine networks: pathways to antiviral defense

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12 December 2020

Idiosyncratic drug hepatotoxicity

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12 December 2020

10.1007/S00228-010-0862-X

Identifiers

DOI

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23 August 2017

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