(Q37779889)

23 August 2017

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title

The role of genetic variants in human longevity (English)

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23 August 2017

Wen-Hung Chung

1

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23 August 2017

Ro-Lan Dao

series ordinal

2

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23 August 2017

Liang-Kung Chen

series ordinal

3

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23 August 2017

Shuen-Iu Hung

series ordinal

4

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23 August 2017

language of work or name

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12 August 2010

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23 August 2017

published in

Ageing Research Reviews

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23 August 2017

volume

9 Suppl 1

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23 August 2017

page(s)

S67-78

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Reduced insulin/IGF-1 signalling and human longevity.

23 August 2017

cites work

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Molecular mechanisms of life- and health-span extension: role of calorie restriction and exercise intervention.

1 reference

12 December 2020

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

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12 December 2020

Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males

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12 December 2020

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

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12 December 2020

Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors

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12 December 2020

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

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12 December 2020

Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study.

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12 December 2020

Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases

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12 December 2020

Apolipoprotein epsilon4 homozygosity and essential hypertension

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12 December 2020

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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12 December 2020

Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration

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12 December 2020

Transglutaminase facilitates the formation of polymers of the beta-amyloid peptide

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12 December 2020

Understanding FOXO, New Views on Old Transcription Factors

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12 December 2020

Sex Differences in the Association of Apolipoprotein E and Angiotensin-Converting Enzyme Gene Polymorphisms With Healthy Aging and Longevity: A Population-Based Study From Southern Italy

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12 December 2020

The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900.

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12 December 2020

p53 in health and disease

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12 December 2020

Role of insulin/insulin-like growth factor 1 signaling pathway in longevity.

1 reference

12 December 2020

Timing requirements for insulin/IGF-1 signaling in C. elegans

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12 December 2020

Cell cycle and death control: long live Forkheads

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12 December 2020

Age-associated accumulation of the apolipoprotein C-III gene T-455C polymorphism C allele in a Russian population

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12 December 2020

Cancer and ageing: rival demons?

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12 December 2020

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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12 December 2020

Apolipoprotein E polymorphism in a healthy Swedish population: variation of allele frequency with age and relation to serum lipid concentrations

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12 December 2020

Galectin-3 expression in human atherosclerotic lesions.

1 reference

12 December 2020

The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene). A relative risk approach.

1 reference

12 December 2020

Codon 72 polymorphism of the TP53 gene

1 reference

12 December 2020

Array-based expression analysis of mouse liver genes: effect of age and of the longevity mutant Prop1df

1 reference

12 December 2020

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

1 reference

12 December 2020

Sex-specific longevity associations defined by Tyrosine Hydroxylase-Insulin-Insulin Growth Factor 2 haplotypes on the 11p15.5 chromosomal region.

1 reference

12 December 2020

No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis

1 reference

12 December 2020

The plasticity of aging: insights from long-lived mutants

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12 December 2020

Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians

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12 December 2020

p53 polymorphic variants at codon 72 exert different effects on cell cycle progression

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12 December 2020

Signals from the reproductive system regulate the lifespan of C. elegans

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12 December 2020

Enhanced gluconeogenesis and increased energy storage as hallmarks of aging in Saccharomyces cerevisiae

1 reference

12 December 2020

Two polymorphic variants of wild-type p53 differ biochemically and biologically

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12 December 2020

p53 and its isoforms in cancer

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12 December 2020

Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

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12 December 2020

Inflammatory networks in ageing, age-related diseases and longevity

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12 December 2020

Association of FOXO3A variation with human longevity confirmed in German centenarians

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12 December 2020

Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity

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12 December 2020

Genetic associations with human longevity at the APOE and ACE loci

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12 December 2020

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

1 reference

12 December 2020

Half of the variation in susceptibility to mortality is genetic: findings from Swedish twin survival data

1 reference

12 December 2020

A maximum likelihood method for analyzing pseudogene evolution: implications for silent site evolution in humans and rodents

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12 December 2020

Midlife risk factors and healthy survival in men

1 reference

12 December 2020

Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort.

1 reference

12 December 2020

Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2).

1 reference

12 December 2020

Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways

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12 December 2020

The neck-region polymorphism of DC-SIGNR in peri-centenarian from Han Chinese population

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12 December 2020

Premature ageing in transgenic mice expressing different growth hormone genes

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12 December 2020

Association between serum paraoxonase (PON1) gene promoter T(-107)C polymorphism, PON1 activity and HDL levels in healthy Sicilian octogenarians

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12 December 2020

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

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12 December 2020

Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm

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12 December 2020

Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation.

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12 December 2020

Stressing the role of FoxO proteins in lifespan and disease

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12 December 2020

FOXO transcription factors at the interface between longevity and tumor suppression

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12 December 2020

Synoviocytes from osteoarthritis and rheumatoid arthritis produce plasminogen activators and plasminogen activator inhibitor-1 and display u-PA receptors on their surface

1 reference

12 December 2020

Apolipoprotein E genetic variation and Alzheimer's disease. a meta-analysis.

1 reference

12 December 2020

Paraoxonase (PON1) polymorphisms in farmers attributing ill health to sheep dip.

1 reference

12 December 2020

Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities

1 reference

12 December 2020

Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population

1 reference

12 December 2020

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

1 reference

12 December 2020

p53 polymorphism and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population.

1 reference

12 December 2020

In search of a biological pattern for human longevity: impact of apo A-IV genetic polymorphisms on lipoproteins and the hyper-Lp(a) in centenarians

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12 December 2020

FOXO3A genotype is strongly associated with human longevity

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12 December 2020

The insulin paradox: aging, proteotoxicity and neurodegeneration

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12 December 2020

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

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12 December 2020

The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

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12 December 2020

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

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12 December 2020

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

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12 December 2020

The quest for genetic determinants of human longevity: challenges and insights

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12 December 2020

DAF-16 target genes that control C. elegans life-span and metabolism.

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12 December 2020

DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus

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12 December 2020

Role of a p53 polymorphism in the development of human papillomavirus-associated cancer

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12 December 2020

Regulation of C. elegans life-span by insulinlike signaling in the nervous system

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12 December 2020

Association of apolipoprotein E polymorphism with myocardial infarction in Greek patients with coronary artery disease

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12 December 2020

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

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12 December 2020

Genetic links between diet and lifespan: shared mechanisms from yeast to humans

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12 December 2020

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

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12 December 2020

PON1 is a longevity gene: results of a meta-analysis

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12 December 2020

Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control

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12 December 2020

Extreme discordant sib pairs for mapping quantitative trait loci in humans

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12 December 2020

Immunity and ageing in man: Annual Review 2006/2007.

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12 December 2020

Apolipoproteins and aging: emerging mechanisms

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12 December 2020

DC-SIGN and DC-SIGNR genetic diversity among different ethnic populations: potential implications for pathogen recognition and disease susceptibility

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12 December 2020

Regulation of serum amyloid A protein expression during the acute-phase response

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12 December 2020

Reactive oxygen species production by mitochondria.

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12 December 2020

A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease

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12 December 2020

A study of French centenarians: are ACE and APOE associated with longevity?

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12 December 2020

Variation in the human TP53 gene affects old age survival and cancer mortality.

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12 December 2020

Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population

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12 December 2020

Positional cloning of the Werner's syndrome gene

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12 December 2020

Endocrine regulation of ageing

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12 December 2020

Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study.

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12 December 2020

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

1 reference

12 December 2020

Apolipoprotein E polymorphism, age and coronary heart disease

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12 December 2020

Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.

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12 December 2020

Evolutionary pressure on mitochondrial cytochrome b is consistent with a role of CytbI7T affecting longevity during caloric restriction

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12 December 2020

Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes

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12 December 2020

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

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12 December 2020

p53 variants predisposing to cancer are present in healthy centenarians

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12 December 2020

Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism

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12 December 2020

Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

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12 December 2020

The common germline Arg72Pro polymorphism of p53 and increased longevity in humans

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12 December 2020

Effect of six candidate genes on early aging in a French population

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12 December 2020

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

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12 December 2020

Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway

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12 December 2020

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

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12 December 2020

Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study

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12 December 2020

Apolipoprotein E Alleles and Risk of Coronary Disease

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12 December 2020

Enrichment of regulatory motifs upstream of predicted DAF-16 targets

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12 December 2020

Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls.

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12 December 2020

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

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12 December 2020

P53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia.

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12 December 2020

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

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12 December 2020

AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR.

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12 December 2020

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

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12 December 2020

A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands

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12 December 2020

Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome

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12 December 2020

Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians

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12 December 2020

Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis

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12 December 2020

10.1016/J.ARR.2010.08.001

Identifiers

DOI

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23 August 2017

0 references

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