(Q37782076)

23 August 2017

title

Polymer-drug conjugates for novel molecular targets (English)

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23 August 2017

Joaquin Sanchis

1

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ORCID Public Data File 2021

author name string

Fabiana Canal

series ordinal

2

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23 August 2017

Rut Lucas

series ordinal

3

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23 August 2017

María J Vicent

series ordinal

4

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23 August 2017

publication date

1 August 2010

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23 August 2017

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23 August 2017

volume

5

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23 August 2017

issue

6

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23 August 2017

page(s)

915-935

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The dawning era of polymer therapeutics

23 August 2017

cites work

1 reference

Polymer therapeutics: concepts and applications

21 January 2018

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Polymer conjugates as anticancer nanomedicines

21 January 2018

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Polymer-drug conjugates: recent development in clinical oncology

21 January 2018

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Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel

21 January 2018

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XMT-1001, a novel polymeric camptothecin pro-drug in clinical development for patients with advanced cancer

21 January 2018

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Ligand-targeted therapeutics in anticancer therapy

21 January 2018

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Trends in immunoconjugate and ligand-receptor based targeting development for cancer therapy

21 January 2018

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Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin

21 January 2018

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Exploiting the enhanced permeability and retention effect for tumor targeting

21 January 2018

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Polymer conjugates: nanosized medicines for treating cancer

21 January 2018

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Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer-drug conjugate

21 January 2018

1 reference

Phase I clinical and pharmacokinetic trial of dextran conjugated doxorubicin (AD-70, DOX-OXD).

21 January 2018

1 reference

Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple cancer models

21 January 2018

1 reference

Phase I and pharmacokinetic (PK) study of MAG-CPT (PNU 166148): a polymeric derivative of camptothecin (CPT)

21 January 2018

1 reference

Phase I pharmacokinetic, food effect, and pharmacogenetic study of oral irinotecan given as semisolid matrix capsules in patients with solid tumors

21 January 2018

1 reference

Design and development of IT-101, a cyclodextrin-containing polymer conjugate of camptothecin

21 January 2018

1 reference

Paclitaxel poliglumex (XYOTAX; CT-2103): an intracellularly targeted taxane.

21 January 2018

1 reference

ProLindac (AP5346): a review of the development of an HPMA DACH platinum Polymer Therapeutic

21 January 2018

1 reference

Polymer-drug conjugates: current status and future trends

21 January 2018

1 reference

Polymeric carriers: preclinical safety and the regulatory implications for design and development of polymer therapeutics.

21 January 2018

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Improving the efficacy of combined modality anticancer therapy using HPMA copolymer-based nanomedicine formulations.

21 January 2018

1 reference

Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines

21 January 2018

1 reference

HPMA copolymers: 30 years of advances.

21 January 2018

1 reference

21 January 2018

The Hallmarks of Cancer

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Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

21 January 2018

1 reference

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

21 January 2018

1 reference

Water-soluble HPMA copolymer-wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo

21 January 2018

1 reference

Mixed polymeric micelles for combination cancer chemotherapy through the concurrent delivery of multiple chemotherapeutic agents

21 January 2018

1 reference

"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets

21 January 2018

1 reference

Sphingosine-1-phosphate mediates transcriptional regulation of key targets associated with survival, proliferation, and pluripotency in human embryonic stem cells

21 January 2018

1 reference

New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets

21 January 2018

1 reference

N,N-Dimethylsphingosine conjugates of poly-L-glutamic acid: synthesis, characterization, and initial biological evaluation

21 January 2018

1 reference

Hsp90: chaperoning signal transduction

21 January 2018

1 reference

Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

21 January 2018

1 reference

Targetable HPMA copolymer-aminohexylgeldanamycin conjugates for prostate cancer therapy

21 January 2018

1 reference

Intelligent biosynthetic nanobiomaterials for hyperthermic combination chemotherapy and thermal drug targeting of HSP90 inhibitor geldanamycin

21 January 2018

1 reference

Apoptosis: target for novel drugs

21 January 2018

1 reference

Apoptosis-based therapies

21 January 2018

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Apoptotic pathways: ten minutes to dead

21 January 2018

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Polymer-drug conjugates as modulators of cellular apoptosis

21 January 2018

1 reference

Curcumin: the story so far.

21 January 2018

1 reference

Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1.

21 January 2018

1 reference

Shooting at survivors: Bcl-2 family members as drug targets for cancer

21 January 2018

1 reference

HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines

21 January 2018

1 reference

Polymer therapeutics designed for a combination therapy of hormone-dependent cancer

21 January 2018

1 reference

Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells.

21 January 2018

1 reference

Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers

21 January 2018

1 reference

Cardiac safety and antitumoral activity of a new nitric oxide derivative of pegylated epirubicin in mice

21 January 2018

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Tumor angiogenesis: therapeutic implications

21 January 2018

1 reference

Design and development of polymer conjugates as anti-angiogenic agents

21 January 2018

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Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470.

21 January 2018

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Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin

21 January 2018

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Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma

21 January 2018

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An orally delivered small-molecule formulation with antiangiogenic and anticancer activity

21 January 2018

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Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics

21 January 2018

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Targeting bone metastases with a bispecific anticancer and antiangiogenic polymer-alendronate-taxane conjugate

21 January 2018

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Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates

21 January 2018

1 reference

Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy

21 January 2018

1 reference

Synthesis and biological in vitro evaluation of novel PEG-psoralen conjugates

21 January 2018

1 reference

Polymer-phloridzin conjugates as an anti-diabetic drug that inhibits glucose absorption through the Na+/glucose cotransporter (SGLT1) in the small intestine

21 January 2018

1 reference

Stabilization of enzyme-susceptible glucoside bonds of phloridzin through conjugation with poly(gamma-glutamic acid).

21 January 2018

1 reference

SMA-copolymer conjugate of AHPP: a polymeric inhibitor of xanthine oxidase with potential antihypertensive effect.

21 January 2018

1 reference

21 January 2018

HIV-protease inhibitors

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Synthesis of poly(ethylene glycol)-based saquinavir prodrug conjugates and assessment of release and anti-HIV-1 bioactivity using a novel protease inhibition assay

21 January 2018

1 reference

Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects

21 January 2018

1 reference

Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities

21 January 2018

1 reference

A novel anti-HIV dextrin-zidovudine conjugate improving the pharmacokinetics of zidovudine in rats

21 January 2018

1 reference

Studies of macromolecular prodrugs of zidovudine

21 January 2018

1 reference

Synthesis, analysis, in vitro characterization, and in vivo disposition of a lamivudine-dextran conjugate for selective antiviral delivery to the liver

21 January 2018

1 reference

Synthesis and characterisation of a new amphotericin B-methoxypoly(ethylene glycol) conjugate

21 January 2018

1 reference

New targeting system for antimycotic drugs: beta-glucosidase sensitive amphotericin B-star poly(ethylene glycol) conjugate

21 January 2018

1 reference

Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?

21 January 2018

1 reference

Safety and effectiveness of amphotericin B deoxycholate for the treatment of visceral leishmaniasis in Uganda

21 January 2018

1 reference

N-(2-hydroxypropyl)methacrylamide-amphotericin B (HPMA-AmB) copolymer conjugates as antileishmanial agents

21 January 2018

1 reference

Selective delivery of drugs to macrophages through a highly specific receptor. An efficient chemotherapeutic approach against leishmaniasis

21 January 2018

1 reference

Targetable water-soluble polymer-drug conjugates for the treatment of visceral leishmaniasis

21 January 2018

1 reference

Drotrecogin alpha (activated): the treatment for severe sepsis?

21 January 2018

1 reference

Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review

21 January 2018

1 reference

Extracorporeal endotoxin removal for the treatment of sepsis: endotoxin adsorption cartridge (Toraymyxin)

21 January 2018

1 reference

Nanoconjugates as intracorporeal neutralizers of bacterial endotoxins.

21 January 2018

1 reference

PEG conjugates in clinical development or use as anticancer agents: an overview

21 January 2018

1 reference

Colon-specific delivery of budesonide from microencapsulated cellulosic cores: evaluation of the efficacy against colonic inflammation in rats

21 January 2018

1 reference

Synthesis and evaluation of dextran-budesonide conjugates as colon specific prodrugs for treatment of ulcerative colitis

21 January 2018

1 reference

Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers.

21 January 2018

1 reference

21 January 2018

Dampening inflammation

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Beyond oncology--application of HPMA copolymers in non-cancerous diseases.

21 January 2018

1 reference

Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis.

21 January 2018

1 reference

Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery

21 January 2018

1 reference

Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair.

21 January 2018

1 reference

Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine.

21 January 2018

1 reference

Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation.

21 January 2018

1 reference

The ischemic penumbra: identification, evolution and treatment concepts

21 January 2018

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Microvascular oxygenation, oxidative stress, NO suppression and superoxide dismutase during postischemic reperfusion.

21 January 2018

1 reference

Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors

21 January 2018

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Effects of hormone replacement therapy on coagulation and fibrinolysis in postmenopausal women

21 January 2018

1 reference

Oestrogenic repression of human coagulation factor VII expression mediated through an oestrogen response element sequence motif in the promoter region

21 January 2018

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Intraluminal-restricted 17 beta-estradiol exerts the same myocardial protection against ischemia/reperfusion injury in vivo as free 17 beta-estradiol

21 January 2018

1 reference

Polyethylene glycol and a novel developed polyethylene glycol-nitric oxide normalize arteriolar response and oxidative stress in ischemia-reperfusion.

21 January 2018

1 reference

Bone-targeting macromolecular therapeutics.

21 January 2018

1 reference

Hormones and bone health in postmenopausal women

21 January 2018

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Release of prostaglandin E(1) from N-(2-hydroxypropyl)methacrylamide copolymer conjugates by bone cells

21 January 2018

1 reference

Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates.

21 January 2018

1 reference

Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems.

21 January 2018

1 reference

The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review

21 January 2018

1 reference

A phase I and pharmacokinetic study of pegylated camptothecin as a 1-hour infusion every 3 weeks in patients with advanced solid malignancies

21 January 2018

1 reference

Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer

21 January 2018

1 reference

Polymer Therapeutics for Cancer: Current Status and Future Challenges

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/NNM.10.71

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23 August 2017

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