(Q37805517)

23 August 2017

title

Modulation of toll-like receptor function has therapeutic potential in autoimmune disease (English)

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23 August 2017

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2

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author name string

Felix I L Clanchy

series ordinal

1

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23 August 2017

language of work or name

English

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publication date

2 November 2010

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Expert Opinion on Biological Therapy

23 August 2017

published in

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23 August 2017

volume

10

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23 August 2017

issue

12

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23 August 2017

page(s)

1703-1716

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Clustering and commonalities among autoimmune diseases

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Epidemiology and estimated population burden of selected autoimmune diseases in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

How immune mechanisms are affected by pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Effects of tobacco smoke on immunity, inflammation and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

From inflammation to sickness and depression: when the immune system subjugates the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

The roles of TLRs, RLRs and NLRs in pathogen recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

The extra domain A of fibronectin activates Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Chlamydia trachomatis nucleic acids can be found in the synovium of some asymptomatic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Quantitative analysis of hyaluronan in the synovial tissues of patients with joint disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

TBK1-targeted suppression of TRIF-dependent signaling pathway of toll-like receptor 3 by auranofin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Staphylococcal peptidoglycans induce arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

A novel therapy of murine collagen-induced arthritis with soluble T1/ST2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Polymorphism at position +896 of the toll-like receptor 4 gene interferes with rapid response to treatment in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Mode of action of hydroxychloroquine in RA-evidence of an inhibitory effect on toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Suppressive oligonucleotides protect against collagen-induced arthritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Impaired early B cell tolerance in patients with rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Defective B cell tolerance checkpoints in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

LPS augments adoptive transfer of experimental allergic encephalomyelitis in the Lewis rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Broad expression of Toll-like receptors in the human central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

The microtubule regulator stathmin is an endogenous protein agonist for TLR3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Effect of viral infection on experimental allergic encephalomyelitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Multiple sclerosis: infectious hypothesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

The 1982 revised criteria for the classification of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Identification of new SLE-associated genes with a two-step Bayesian study design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Effects of age, gender, and immunosuppressive agents on in vivo toll-like receptor pathway responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

A Tlr7 translocation accelerates systemic autoimmunity in murine lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Pyogenic bacterial infections in humans with MyD88 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

RDP58, a novel immunomodulatory peptide, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

RDP58 is a novel and potentially effective oral therapy for ulcerative colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by 6-shogaol, an active component of ginger

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Zingiber officinale protects HaCaT cells and C57BL/6 mice from ultraviolet B-induced inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Non-enterobacterial endotoxins stimulate human coronary artery but not venous endothelial cell activation via Toll-like receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Single-stranded oligonucleotides can inhibit cytokine production induced by human toll-like receptor 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Ligand-induced conformational changes allosterically activate Toll-like receptor 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Therapy: Hydroxychloroquine in SLE: old drug, new perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

IRF-7 is the master regulator of type-I interferon-dependent immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Herpes simplex virus encephalitis in human UNC-93B deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytoki

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

CD14-independent responses induced by a synthetic lipid A mimetic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Proinflammatory Bacterial Peptidoglycan as a Cofactor for the Development of Central Nervous System Autoimmune Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2010.534080

10.1517/14712598.2010.534080

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference