(Q37806068)

23 August 2017

Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes (English)

1 reference

23 August 2017

0 references

1 reference

Gerald Wirnsberger

1

1 reference

PubMed ID

21042335

23 August 2017

Maria Hinterberger

series ordinal

2

1 reference

PubMed ID

21042335

23 August 2017

Ludger Klein

series ordinal

3

1 reference

23 August 2017

2 November 2010

1 reference

Immunology & Cell Biology

23 August 2017

1 reference

23 August 2017

89

1 reference

23 August 2017

1

1 reference

23 August 2017

45-53

1 reference

T cell tolerance by clonal elimination in the thymus

23 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

A central role for central tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Transcriptional regulation by AIRE: molecular mechanisms of central tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Positional cloning of the APECED gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Control of regulatory T cell lineage commitment and maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

The Le Douarin phenomenon: a shift in the paradigm of developmental self-tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

CD4+ CD25+ regulatory T cell repertoire formation in response to varying expression of a neo-self-antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Thymocyte deletion can bias Treg formation toward low-abundance self-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Agonist ligands expressed by thymic epithelium enhance positive selection of regulatory T lymphocytes from precursors with a normally diverse TCR repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

T cells compete for access to antigen-bearing antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Visualizing T cell competition for peptide/MHC complexes: a specific mechanism to minimize the effect of precursor frequency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Thymocyte development is normal in CTLA-4-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

In vivo overexpression of CTLA-4 suppresses lymphoproliferative diseases and thymic negative selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

CTLA-4 ligation blocks CD28-dependent T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

A function for interleukin 2 in Foxp3-expressing regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Nonredundant roles for Stat5a/b in directly regulating Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

A two-step process for thymic regulatory T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

TGF-beta: a master of all T cell trades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Positive and negative selection of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Spontaneous expression of interleukin-2 in vivo in specific tissues of young mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Developmental regulation of Foxp3 expression during ontogeny.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Differentiation of regulatory Foxp3+ T cells in the thymic cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Negative selection in the thymus includes semimature T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Generating intrathymic microenvironments to establish T-cell tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Antigen presentation in the thymus for positive selection and central tolerance induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Aire regulates negative selection of organ-specific T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Quantitative impact of thymic clonal deletion on the T cell repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Dendritic cells in the thymus contribute to T-regulatory cell induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Heterogeneity of thymic dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Affinity-based selection of regulatory T cells occurs independent of agonist-mediated induction of Foxp3 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

How specificity for self-peptides shapes the development and function of regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Adaptable TCR avidity thresholds for negative selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Preferential recognition of self antigens despite normal thymic deletion of CD4(+)CD25(+) regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Functional flexibility in T cells: independent regulation of CD4+ T cell proliferation and effector function in vivo

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Role of B7 in T cell tolerance

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Lymphocyte activation: T-cell regulation by CTLA-4

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Tracing the action of IL-2 in tolerance to islet-specific antigen

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Selective availability of IL-2 is a major determinant controlling the production of CD4+CD25+Foxp3+ T regulatory cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.123

7 January 2021

Identifiers

DOI

10.1038/ICB.2010.123

1 reference

23 August 2017

1 reference

PubMed ID

21042335