(Q37807986)

23 August 2017

The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease (English)

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23 August 2017

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2

Mark T Kearney

1 reference

23 August 2017

Victoria K Gatenby

1

1 reference

PubMed ID

21058922

23 August 2017

language of work or name

English

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publication date

1 December 2010

1 reference

Expert Opinion on Therapeutic Targets

23 August 2017

1 reference

23 August 2017

14

1 reference

23 August 2017

1333-1342

1 reference

23 August 2017

12

1 reference

Obesity and age of first non-ST-segment elevation myocardial infarction.

23 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Hyperglycaemia, in relation to sex, and mortality after acute coronary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Temporal trends in mortality of patients with diabetes mellitus suffering acute myocardial infarction: a comparison of over 3000 patients between 1995 and 2003

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Aspirin and mortality in patients with diabetes sustaining acute coronary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Diabetes mellitus and mortality after acute coronary syndrome as a first or recurrent cardiovascular event

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Effects of intensive glucose lowering in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Glucose control and vascular complications in veterans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Pathophysiological implications of insulin resistance on vascular endothelial function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Insulin resistance and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Unraveling the mechanism of action of thiazolidinediones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Does glucagon-like peptide-1 receptor agonist therapy add value in the treatment of type 2 diabetes? Focus on exenatide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Atherosclerosis — An Inflammatory Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Translating molecular discoveries into new therapies for atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Nitric oxide modulates expression of cell cycle regulatory proteins: a cytostatic strategy for inhibition of human vascular smooth muscle cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Application of the nitric oxide donor SNAP to cardiomyocytes in culture provides protection against oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Rapid regulation of platelet activation in vivo by nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Insulin resistance, lipotoxicity and endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Insulin resistance and endothelial cell dysfunction: studies in mammalian models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Vascular dysfunction and reduced circulating endothelial progenitor cells in young healthy UK South Asian men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Effect of fat distribution on endothelial-dependent and endothelial-independent vasodilatation in healthy humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Endothelial function and weight loss in obese humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

The association between saphenous vein endothelial function, systemic inflammation, and statin therapy in patients undergoing coronary artery bypass surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance. Effects of troglitazone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Effect of endothelium-specific insulin resistance on endothelial function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

SMK-1, an essential regulator of DAF-16-mediated longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Timing requirements for insulin/IGF-1 signaling in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Leukocyte antigen-related deficiency enhances insulin-like growth factor-1 signaling in vascular smooth muscle cells and promotes neointima formation in response to vascular injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

IGF-1 reduces inflammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Insulin-like growth factor I receptors are more abundant than insulin receptors in human micro- and macrovascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Vascular responses to IGF-I and insulin are impaired in aortae of hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Vascular insulin-like growth factor-I resistance and diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Signalling through IGF-I and insulin receptors: where is the specificity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I) or insulin/IGF-I hybrid receptors in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

The vascular endothelial cell mediates insulin transport into skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Insulin signaling stimulates insulin transport by bovine aortic endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Functionally significant insulin-like growth factor I receptor mutations in centenarians

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Structural biology of insulin and IGF1 receptors: implications for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Characterisation of receptors for IGF-I and insulin; evidence for hybrid insulin/IGF-I receptor in human coronary artery endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Insulin-like growth factor-1 receptor expression masks the antiinflammatory and glucose uptake capacity of insulin in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Clinical and functional characteristics of the human Arg59Ter insulin-like growth factor i receptor (IGF1R) mutation: implications for a gene dosage effect of the human IGF1R.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Rh/IGF-I/rhIGFBP-3 administration to patients with type 2 diabetes mellitus reduces insulin requirements while also lowering fasting glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Vascular endothelial function and blood pressure homeostasis in mice overexpressing IGF binding protein-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Targeting insulin and insulin-like growth factor signalling in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Targeting insulin-like growth factor pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

Decreased Expression of Insulin-like Growth Factor-1 and Apoptosis of Vascular Smooth Muscle Cells in Human Atherosclerotic Plaque

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528930

10.1517/14728222.2010.528930

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference

PubMed ID

21058922