(Q37808106)

23 August 2017

title

The epigenome as a therapeutic target in prostate cancer (English)

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23 August 2017

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1

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author name string

R William G Watson

series ordinal

2

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23 August 2017

Mark Lawler

series ordinal

3

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23 August 2017

Donal Hollywood

series ordinal

4

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23 August 2017

language of work or name

English

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publication date

9 November 2010

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23 August 2017

published in

Nature Reviews Urology

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23 August 2017

volume

7

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23 August 2017

issue

12

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23 August 2017

page(s)

668-680

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https://scigraph.springernature.com/pub.10.1038/nrurol.2010.185

23 August 2017

exact match

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Regulation of E2F1 activity by acetylation

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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Stat3 dimerization regulated by reversible acetylation of a single lysine residue

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Duration of nuclear NF-kappaB action regulated by reversible acetylation

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Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

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DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

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Site-specific acetylation of p53 directs selective transcription complex assembly.

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Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

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Cellular differentiation, cytidine analogs and DNA methylation

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Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

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31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Epigenetics in human disease and prospects for epigenetic therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Azacitidine favorably modulates PSA kinetics correlating with plasma DNA LINE-1 hypomethylation in men with chemonaïve castration-resistant prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

A phase II study of 5-aza-2'deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Inhibition of DNA methylation and reactivation of silenced genes by zebularine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

The epigenetic progenitor origin of human cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Preneoplastic prostate lesions: an opportunity for prostate cancer prevention

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Suppression of intestinal neoplasia by DNA hypomethylation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Dietary polyphenols may affect DNA methylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Chemokines and B cells in renal inflammation and allograft rejection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Epigenetic regulation of androgen receptor gene expression in human prostate cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Enhancement of xenograft tumor radiosensitivity by the histone deacetylase inhibitor MS-275 and correlation with histone hyperacetylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Peroxisome proliferator-activated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

SAHA-sensitized prostate cancer cells to TNFalpha-related apoptosis-inducing ligand (TRAIL): mechanisms leading to synergistic apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Histone deacetylase inhibitors enhance Ad5-TRAIL killing of TRAIL-resistant prostate tumor cells through increased caspase-2 activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Depsipeptide (FR901228) enhances the cytotoxic activity of TRAIL by redistributing TRAIL receptor to membrane lipid rafts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Synergy of 5-aza-2'-deoxycytidine (DAC) and paclitaxel in both androgen-dependent and -independent prostate cancer cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

5-aza-2'-deoxycytidine delays androgen-independent disease and improves survival in the transgenic adenocarcinoma of the mouse prostate mouse model of prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

5-Azacitidine restores and amplifies the bicalutamide response on preclinical models of androgen receptor expressing or deficient prostate tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

CpG island hypermethylation profile in the serum of men with clinically localized and hormone refractory metastatic prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Genetic unmasking of an epigenetically silenced microRNA in human cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Small interfering RNA-induced transcriptional gene silencing in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Methylation status of uPA promoter as a molecular mechanism regulating prostate cancer invasion and growth in vitro and in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

DNA methylation in cancer: too much, but also too little

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Conserved metabolic regulatory functions of sirtuins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.185

Regional loss of imprinting of the insulin-like growth factor II gene occurs in human prostate tissues.

31 March 2020

1 reference

12 December 2020

Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer

1 reference

12 December 2020

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo

1 reference

12 December 2020

Low concentrations of the histone deacetylase inhibitor, depsipeptide, enhance the effects of gemcitabine and docetaxel in hormone refractory prostate cancer cells

1 reference

12 December 2020

Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.

1 reference

12 December 2020

Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation

1 reference

12 December 2020

Methylation of the androgen receptor promoter CpG island is associated with loss of androgen receptor expression in prostate cancer cells

1 reference

12 December 2020

Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer

1 reference

12 December 2020

Induction of bicalutamide sensitivity in prostate cancer cells by an epigenetic Puralpha-mediated decrease in androgen receptor levels

1 reference

12 December 2020

Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines

1 reference

12 December 2020

Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide

1 reference

12 December 2020

CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia

1 reference

12 December 2020

Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells.

1 reference

12 December 2020

Enhanced sensitivity of prostate cancer DU145 cells to cisplatinum by 5-aza-2'-deoxycytidine.

1 reference

12 December 2020

Involvement of Bcl-2 family members, phosphatidylinositol 3'-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer

1 reference

12 December 2020

In vitro neoplastic progression of rat tracheal epithelial cells transformed by diverse carcinogens.

1 reference

12 December 2020

Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features

1 reference

12 December 2020

The irreversible binding of azacytosine-containing DNA fragments to bacterial DNA(cytosine-5)methyltransferases

1 reference

12 December 2020

Distribution of kinase and deaminase of 1-beta-D-arabinofuranosylcytosine in tissues of man and mouse

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRUROL.2010.185

1 reference

Dimensions Publication ID

23 August 2017

1005903637

0 references

1 reference