(Q37810949)

23 August 2017

title

Retinoic acid receptor modulators: a perspective on recent advances and promises (English)

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23 August 2017

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2

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Hinrich Gronemeyer

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3

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Angel R de Lera

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4

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author name string

Susana Alvarez

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1

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23 August 2017

language of work or name

English

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publication date

20 November 2010

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Expert Opinion on Therapeutic Patents

23 August 2017

published in

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23 August 2017

volume

21

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23 August 2017

issue

1

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23 August 2017

page(s)

55-63

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International Union of Pharmacology. LX. Retinoic acid receptors

23 August 2017

cites work

1 reference

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Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation

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Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response

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Principles for modulation of the nuclear receptor superfamily

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Inverse agonists and antagonists of retinoid receptors

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RAR and RXR modulation in cancer and metabolic disease

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Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

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Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics

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Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

21 January 2018

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Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

21 January 2018

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Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers

21 January 2018

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Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists

21 January 2018

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A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor

21 January 2018

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Design of selective nuclear receptor modulators: RAR and RXR as a case study

21 January 2018

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Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists

21 January 2018

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C3 halogen and c8'' substituents on stilbene arotinoids modulate retinoic Acid receptor subtype function

21 January 2018

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Pyrazine arotinoids with inverse agonist activities on the retinoid and rexinoid receptors

21 January 2018

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Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists

21 January 2018

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Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells.

21 January 2018

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Identification of novel subtype selective RAR agonists

21 January 2018

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Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist

21 January 2018

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Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands

21 January 2018

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The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo

21 January 2018

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SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis

21 January 2018

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Mechanism of the nuclear receptor molecular switch

21 January 2018

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The prospects of retinoids in the treatment of prostate cancer.

21 January 2018

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A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promoter

21 January 2018

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A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity

21 January 2018

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Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

21 January 2018

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The promise of retinoids to fight against cancer.

21 January 2018

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Retinoids in cancer therapy and chemoprevention: promise meets resistance

21 January 2018

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Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor

21 January 2018

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Anticancer activities of histone deacetylase inhibitors

21 January 2018

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Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro.

21 January 2018

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Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARalpha agonist AM580.

21 January 2018

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ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome

21 January 2018

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NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome

21 January 2018

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Retinoic acid in development: towards an integrated view

21 January 2018

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Cell reprogramming: expectations and challenges for chemistry in stem cell biology and regenerative medicine

21 January 2018

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Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative beta-catenin.

21 January 2018

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Retinoic acid receptor beta2 promotes functional regeneration of sensory axons in the spinal cord

21 January 2018

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All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease

21 January 2018

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Retinoids differentially regulate the progression of autoimmune diabetes in three preclinical models in mice

21 January 2018

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Therapeutic applications for ligands of retinoid receptors

21 January 2018

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10.1517/13543776.2011.536531

21 January 2018

Identifiers

DOI

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23 August 2017

1 reference