(Q37812670)

23 August 2017

title

Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters (English)

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23 August 2017

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23 August 2017

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author name string

Tadashi Yokosuka

series ordinal

2

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23 August 2017

language of work or name

English

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publication date

24 November 2010

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23 August 2017

number of pages

7

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based on heuristic

inferred from page(s)

published in

FEBS Letters

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23 August 2017

volume

584

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23 August 2017

issue

24

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23 August 2017

page(s)

4865-4871

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Three-dimensional segregation of supramolecular activation clusters in T cells

23 August 2017

cites work

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Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

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TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

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Persistence of cooperatively stabilized signaling clusters drives T-cell activation

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The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality

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Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

21 January 2018

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21 January 2018

Identifiers

DOI

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23 August 2017

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