(Q37813134)

23 August 2017

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title

Signal transducer and activator of transcription 3 inhibitors: a patent review (English)

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23 August 2017

Brent D G Page

1

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23 August 2017

Daniel P Ball

series ordinal

2

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23 August 2017

Patrick T Gunning

series ordinal

3

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23 August 2017

language of work or name

English

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publication date

29 November 2010

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Expert Opinion on Therapeutic Patents

23 August 2017

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23 August 2017

21

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23 August 2017

1

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23 August 2017

65-83

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Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein

23 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Stat proteins and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

STATs and gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Targeting Stat3 in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Cellular physiology of STAT3: Where's the cytoplasmic monomer?

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2011.539205

STATs dimerize in the absence of phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Transcription factors as targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

A family of cytokine-inducible inhibitors of signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Specific inhibition of Stat3 signal transduction by PIAS3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Inhibition of transcription factors with small organic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Fluacrypyrim, a novel STAT3 activation inhibitor, induces cell cycle arrest and apoptosis in cancer cells harboring constitutively-active STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

TRIM8 modulates STAT3 activity through negative regulation of PIAS3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Chemical probes that competitively and selectively inhibit Stat3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Identification of a high-affinity phosphopeptide inhibitor of Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Design, synthesis, and studies of small molecule STAT3 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Targeting transcription factors for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

A high-throughput fluorescence polarization assay for signal transducer and activator of transcription 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Development and validation of a genetic algorithm for flexible docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Functional importance of Stat3 tetramerization in activation of the alpha 2-macroglobulin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

A Novel Sequence in the Coiled-coil Domain of Stat3 Essential for Its Nuclear Translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Three-dimensional structure of the Stat3beta homodimer bound to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

In situ end labeling of fragmented DNA in induced ovarian atresia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Lack of toxicity of a STAT3 decoy oligonucleotide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

Roles of Protein-tyrosine Phosphatases in Stat1 -mediated Cell Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.539205

10.1517/13543776.2011.539205

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference