(Q37821750)

23 August 2017

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title

Chemical modulators of autophagy as biological probes and potential therapeutics (English)

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23 August 2017

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2

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Angeleen Fleming

object named as

Angeleen Fleming

series ordinal

1

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Tamotsu Yoshimori

series ordinal

3

object named as

Tamotsu Yoshimori

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23 August 2017

David C Rubinsztein

4

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23 August 2017

publication date

1 January 2011

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23 August 2017

published in

Nature Chemical Biology

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23 August 2017

volume

7

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23 August 2017

issue

1

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23 August 2017

page(s)

9-17

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The role of autophagy during the oocyte-to-embryo transition.

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.500

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.500

Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.500

Intracellular quality control by autophagy: how does autophagy prevent neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.500

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.500

Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.500

The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.500

Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens

21 January 2018

1 reference

12 December 2020

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain

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12 December 2020

Lithium induces autophagy by inhibiting inositol monophosphatase

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12 December 2020

The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice

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12 December 2020

The IKK complex contributes to the induction of autophagy

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12 December 2020

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

1 reference

12 December 2020

The life span-prolonging effect of sirtuin-1 is mediated by autophagy

1 reference

12 December 2020

Induction of autophagy by spermidine promotes longevity

1 reference

12 December 2020

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

1 reference

12 December 2020

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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12 December 2020

Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells

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12 December 2020

How many drug targets are there?

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12 December 2020

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.

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12 December 2020

ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death

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12 December 2020

Crohn disease: a current perspective on genetics, autophagy and immunity

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12 December 2020

Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy

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12 December 2020

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

1 reference

12 December 2020

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

1 reference

12 December 2020

Calorie restriction and aging: review of the literature and implications for studies in humans

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12 December 2020

mTOR Mediated Anti-Cancer Drug Discovery

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12 December 2020

Antipsychotic drugs block IP3-dependent Ca(2+)-release from rat brain microsomes.

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12 December 2020

AMP-activated protein kinase and autophagy

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12 December 2020

Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy

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12 December 2020

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling

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12 December 2020

Dynamics and diversity in autophagy mechanisms: lessons from yeast

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12 December 2020

The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy

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12 December 2020

Regulation of mammalian autophagy in physiology and pathophysiology.

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12 December 2020

Resveratrol-induced autophagocytosis in ovarian cancer cells

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12 December 2020

Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

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12 December 2020

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

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12 December 2020

Trehalose as a "chemical chaperone": fact and fantasy

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12 December 2020

The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers

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12 December 2020

Termination of autophagy and reformation of lysosomes regulated by mTOR

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12 December 2020

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

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12 December 2020

Pharmacological antagonism of calmodulin

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12 December 2020

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

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12 December 2020

Regulation of membrane biogenesis in autophagy via PI3P dynamics

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12 December 2020

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

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12 December 2020

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

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12 December 2020

New insights into the function of Atg9.

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12 December 2020

AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

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12 December 2020

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

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12 December 2020

Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.

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12 December 2020

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

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12 December 2020

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

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12 December 2020

Mitochondria supply membranes for autophagosome biogenesis during starvation

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12 December 2020

Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas

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12 December 2020

The origin of the autophagosomal membrane

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12 December 2020

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

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12 December 2020

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

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12 December 2020

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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12 December 2020

Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells

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12 December 2020

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

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12 December 2020

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

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12 December 2020

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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12 December 2020

The role of the Atg1/ULK1 complex in autophagy regulation

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12 December 2020

The role of autophagy during the early neonatal starvation period

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12 December 2020

The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes

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12 December 2020

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

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12 December 2020

The regulation and function of Class III PI3Ks: novel roles for Vps34.

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12 December 2020

TOR signaling in growth and metabolism

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12 December 2020

Plasma membrane contributes to the formation of pre-autophagosomal structures

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12 December 2020

Autophagy is essential for preimplantation development of mouse embryos

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12 December 2020

Control of basal autophagy by calpain1 mediated cleavage of ATG5

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12 December 2020

GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation.

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12 December 2020

Autophagy genes and ageing

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12 December 2020

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

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12 December 2020

An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure

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12 December 2020

Autophagy, a guardian against neurodegeneration

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12 December 2020

Selective autophagy regulates various cellular functions

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12 December 2020

The effects of p53 on whole organism longevity are mediated by autophagy

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12 December 2020

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

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12 December 2020

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12 December 2020

Autophagy and the integrated stress response

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12 December 2020

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

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12 December 2020

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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12 December 2020

Small molecule regulators of autophagy identified by an image-based high-throughput screen

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12 December 2020

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

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12 December 2020

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

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12 December 2020

Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.

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12 December 2020

The phosphoinositide 3-kinase pathway

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12 December 2020

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.

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12 December 2020

A common mechanism of action for three mood-stabilizing drugs

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12 December 2020

Autophagy: a regulated bulk degradation process inside cells

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12 December 2020

Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies

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12 December 2020

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

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12 December 2020

Valproate decreases inositol biosynthesis

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12 December 2020

Properties of inositol polyphosphate 1-phosphatase

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12 December 2020

Autophagy as a regulated pathway of cellular degradation

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12 December 2020

Role of autophagy in suppression of inflammation and cancer

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12 December 2020

Small molecule enhancers of autophagy for neurodegenerative diseases

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.500

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23 August 2017

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