(Q37825905)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

review article

1 reference

title

Therapeutic targeting of osteoclast function and pathways (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Peter Choong

series ordinal

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

6

Damian E Myers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

3

Crispin R Dass

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Matthew L Broadhead

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Jonathan C M Clark

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

language of work or name

English

0 references

publication date

5 January 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

19 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

169-181

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

Bone remodeling in post-menopausal osteoporosis

19 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteoclast differentiation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Multilineage potential of adult human mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteoclast formation and resorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteoprotegerin deficiency and juvenile Paget's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Phenotypic characterization of early onset Paget's disease of bone caused by a 27-bp duplication in the TNFRSF11A gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Colony stimulating factor-1 plays a role in osteoclast formation and function in bone resorption induced by parathyroid hormone and parathyroid hormone-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

RANK ligand-induced elevation of cytosolic Ca2+ accelerates nuclear translocation of nuclear factor kappa B in osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

NF-kappaB functions in osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

NFAT and Osterix cooperatively regulate bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Integrins and signaling in osteoclast function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

The molecular mechanism behind bone remodelling: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteoclast lineage and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Functions of cathepsin K in bone resorption. Lessons from cathepsin K deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Trafficking of Matrix Collagens Through Bone-Resorbing Osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

The effect of extracellular calcium elevation on morphology and function of isolated rat osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

The calcium-sensing receptor in bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

RANK ligand and osteoprotegerin: paracrine regulators of bone metabolism and vascular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Giant osteoclast formation and long-term oral bisphosphonate therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Zoledronic acid activates the DNA S-phase checkpoint and induces osteosarcoma cell death characterized by apoptosis-inducing factor and endonuclease-G translocation independently of p53 and retinoblastoma status

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteoclasts are essential for TNF-alpha-mediated joint destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Interleukin-17: A new bone acting cytokine in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Effect of interleukin-17 on nitric oxide production and osteoclastic bone resorption: is there dependency on nuclear factor-kappaB and receptor activator of nuclear factor kappaB (RANK)/RANK ligand signaling?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteoprotegerin and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclast formation by cells in the human rheumatoid arthritic joint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Zoledronic acid protects against local and systemic bone loss in tumor necrosis factor-mediated arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Wnt pathway and IL-17: novel regulators of joint remodeling in rheumatic diseases. Looking beyond the RANK-RANKL-OPG axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Bone metabolism changes during anti-TNF-alpha therapy in patients with active rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Denosumab prevents metacarpal shaft cortical bone loss in patients with erosive rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Transforming Growth Factor-Beta in Osteolytic Breast Cancer Bone Metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteoclast differentiation factor in human osteosarcoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Alendronate blocks TGF-beta1 stimulated collagen 1 degradation by human prostate PC-3 ML cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Alendronate inhibits cell invasion and MMP-2 secretion in human chondrosarcoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Alendronate regulates cell invasion and MMP-2 secretion in human osteosarcoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Optimising treatment of bone metastases by Aredia(TM) and Zometa(TM).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Antibody engineering via genetic engineering of the mouse: XenoMouse strains are a vehicle for the facile generation of therapeutic human monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Clinical development of anti-RANKL therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Phase 1 trial of denosumab safety, pharmacokinetics, and pharmacodynamics in Japanese women with breast cancer-related bone metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Long-term effects of infliximab on bone and cartilage turnover markers in patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Effects of denosumab on bone mineral density and bone turnover in patients with rheumatoid arthritis receiving concurrent glucocorticoids or bisphosphonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

Osteoclasts derived from haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.546351

10.1517/14728222.2011.546351

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21204734%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference