(Q37826693)

23 August 2017

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title

Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation (English)

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23 August 2017

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Claire M Williams

4

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author name string

Jonathan A Farrimond

series ordinal

1

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23 August 2017

Marion S Mercier

series ordinal

2

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23 August 2017

Benjamin J Whalley

series ordinal

3

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23 August 2017

publication date

7 January 2011

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23 August 2017

published in

Phytotherapy Research

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23 August 2017

volume

25

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23 August 2017

issue

2

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23 August 2017

page(s)

170-188

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Candidate genes for cannabis use disorders: findings, challenges and directions

23 August 2017

cites work

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Capacitative calcium entry

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A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

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21 January 2018

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Novel cannabinoid receptors

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delta 9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain.

21 January 2018

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The structure of cannabitriol

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Cannabis and endogenous cannabinoid systems.

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The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation

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Brain cannabinoid systems as targets for the therapy of neurological disorders

21 January 2018

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Evaluation of oral cannabinoid-containing medications for the management of interferon and ribavirin-induced anorexia, nausea and weight loss in patients treated for chronic hepatitis C virus

21 January 2018

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The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

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Cannabinoids, opioids and eating behavior: the molecular face of hedonism?

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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

21 January 2018

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The emerging role of cannabinoid neuromodulators in symptom management

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Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase

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21 January 2018

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Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels

21 January 2018

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Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8.

21 January 2018

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Effects of Delta9-tetrahydrocannabivarin on [35S]GTPgammaS binding in mouse brain cerebellum and piriform cortex membranes

21 January 2018

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Isolation and structure of a brain constituent that binds to the cannabinoid receptor

21 January 2018

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Targeting the endocannabinoid system: to enhance or reduce?

21 January 2018

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The endocannabinoid system and its therapeutic exploitation

21 January 2018

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Formation and inactivation of endogenous cannabinoid anandamide in central neurons

21 January 2018

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FAAH and anandamide: is 2-AG really the odd one out?

21 January 2018

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Endocannabinoids and the regulation of their levels in health and disease

21 January 2018

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From lesions to leptin: hypothalamic control of food intake and body weight.

21 January 2018

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Activation of the peripheral endocannabinoid system in human obesity

21 January 2018

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Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats

21 January 2018

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Cannabis constituents modulate δ9-tetrahydrocannabinol-induced hyperphagia in rats

21 January 2018

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A low-Δ9 tetrahydrocannabinol cannabis extract induces hyperphagia in rats

21 January 2018

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Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents

21 January 2018

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Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives

21 January 2018

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Role of endogenous cannabinoids in synaptic signaling

21 January 2018

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The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin

21 January 2018

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Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

21 January 2018

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Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'.

21 January 2018

1 reference

123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors.

21 January 2018

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The role of cannabinoids in neurodegenerative diseases

21 January 2018

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Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain

21 January 2018

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From cannabis to cannabinergics: new therapeutic opportunities

21 January 2018

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Cannabis and endocannabinoid modulators: Therapeutic promises and challenges

21 January 2018

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Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice.

21 January 2018

1 reference

GPR55 ligands promote receptor coupling to multiple signalling pathways

21 January 2018

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The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation

21 January 2018

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Cannabinoid receptor localization in brain

21 January 2018

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Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716.

21 January 2018

1 reference

An endocannabinoid mechanism for stress-induced analgesia.

21 January 2018

1 reference

Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1).

21 January 2018

1 reference

PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats

21 January 2018

1 reference

AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain

21 January 2018

1 reference

The cannabinoid receptors.

21 January 2018

1 reference

The cannabinoid receptor: biochemical, anatomical and behavioral characterization

21 January 2018

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Cannabinoid physiology and pharmacology: 30 years of progress.

21 January 2018

1 reference

Design, Synthesis and Pharmacology of Cannabimimetic Indoles

21 January 2018

1 reference

Emerging therapies for metabolic diseases--the focus is on diabetes and obesity

21 January 2018

1 reference

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

21 January 2018

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Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats

21 January 2018

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Effect of Delta9-tetrahydrocannabinol on sucrose palatability as measured by the taste reactivity test

21 January 2018

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Effect of delta9-tetrahydrocannabinol on quinine palatability and AM251 on sucrose and quinine palatability using the taste reactivity test.

21 January 2018

1 reference

Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners

21 January 2018

1 reference

Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands

21 January 2018

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URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices.

21 January 2018

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Cannabinoid receptor activation in CA1 pyramidal cells in adult rat hippocampus.

21 January 2018

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Endocannabinoids and the neurochemistry of gluttony.

21 January 2018

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Synergistic efects of opioid and cannabinoid antagonists on food intake

21 January 2018

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Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol

21 January 2018

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Delta(9)-THC stimulates food intake in Lewis rats: effects on chow, high-fat and sweet high-fat diets

21 January 2018

1 reference

The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications

21 January 2018

1 reference

SR141716A is an inverse agonist at the human cannabinoid CB1 receptor

21 January 2018

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The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.

21 January 2018

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GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

21 January 2018

1 reference

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma

21 January 2018

1 reference

Multiple pathways involved in the biosynthesis of anandamide

21 January 2018

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Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

21 January 2018

1 reference

The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum

21 January 2018

1 reference

Endocannabinoids: friends and foes of reproduction

21 January 2018

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The endocannabinoid system and its relevance for nutrition.

21 January 2018

1 reference

Mechanisms of CB1 receptor signaling: endocannabinoid modulation of synaptic strength.

21 January 2018

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Therapeutic opportunities through modulation of the endocannabinoid system.

21 January 2018

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Structure of a cannabinoid receptor and functional expression of the cloned cDNA

21 January 2018

1 reference

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

21 January 2018

1 reference

Localization of the CB1 cannabinoid receptor in the rat brain. An immunohistochemical study.

21 January 2018

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Functional CB2 type cannabinoid receptors at CNS synapses

21 January 2018

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Molecular characterization of a peripheral receptor for cannabinoids

21 January 2018

1 reference

Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase

21 January 2018

1 reference

Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells

21 January 2018

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Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals

21 January 2018

1 reference

Molecular characterization of a phospholipase D generating anandamide and its congeners

21 January 2018

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Enzymatic formation of anandamide

21 January 2018

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Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption

21 January 2018

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Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain

21 January 2018

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Endocannabinoids and cannabinoid receptor genetics

21 January 2018

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Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents

21 January 2018

1 reference

GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity

21 January 2018

1 reference

Receptor-independent effects of endocannabinoids on ion channels

21 January 2018

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The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids

21 January 2018

1 reference

GPR55: a new member of the cannabinoid receptor clan?

21 January 2018

1 reference

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin

21 January 2018

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Endocannabinoid chemical biology: a tool for the development of novel therapies

21 January 2018

1 reference

Differential changes in GPR55 during microglial cell activation

21 January 2018

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The molecular logic of endocannabinoid signalling

21 January 2018

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The endocannabinoid system as a target for therapeutic drugs.

21 January 2018

1 reference

Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).

21 January 2018

1 reference

Endocannabinoid signaling in neurotoxicity and neuroprotection

21 January 2018

1 reference

Cannabinoids inhibit neurodegeneration in models of multiple sclerosis

21 January 2018

1 reference

Emerging properties of cannabinoid medicines in management of multiple sclerosis

21 January 2018

1 reference

A model for receptor-regulated calcium entry

21 January 2018

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Cannabinoid-mediated elevation of intracellular calcium: a structure-activity relationship

21 January 2018

1 reference

Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice

21 January 2018

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SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

21 January 2018

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An anorexic lipid mediator regulated by feeding.

21 January 2018

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Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport.

21 January 2018

1 reference

The enigmatic pharmacology of GPR55

21 January 2018

1 reference

Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630

21 January 2018

1 reference

Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels.

21 January 2018

1 reference

The orphan receptor GPR55 is a novel cannabinoid receptor

21 January 2018

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Endocannabinoids and the gastrointestinal tract: what are the key questions?

21 January 2018

1 reference

Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain

21 January 2018

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The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats

21 January 2018

1 reference

Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor

21 January 2018

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Motivational effects of cannabinoids and opioids on food reinforcement depend on simultaneous activation of cannabinoid and opioid systems

21 January 2018

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The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain

21 January 2018

1 reference

Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds

21 January 2018

1 reference

2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain

21 January 2018

1 reference

2-Arachidonoylglycerol and the cannabinoid receptors

21 January 2018

1 reference

Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis

21 January 2018

1 reference

Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist

21 January 2018

1 reference

A comparison of the effects of the CB(1) receptor antagonist SR141716A, pre-feeding and changed palatability on the microstructure of ingestive behaviour.

21 January 2018

1 reference

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review

21 January 2018

1 reference

Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system

21 January 2018

1 reference

Signal transduction of the CB1 cannabinoid receptor

21 January 2018

1 reference

Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

21 January 2018

1 reference

Identification and functional characterization of brainstem cannabinoid CB2 receptors

21 January 2018

1 reference

Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors

21 January 2018

1 reference

Adverse effects of medical cannabinoids: a systematic review

21 January 2018

1 reference

Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats

21 January 2018

1 reference

A novel component of cannabis extract potentiates excitatory synaptic transmission in rat olfactory cortex in vitro.

21 January 2018

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CB1 cannabinoid receptor-mediated modulation of food intake in mice

21 January 2018

1 reference

Medicinal cannabis: is delta9-tetrahydrocannabinol necessary for all its effects?

21 January 2018

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Observational analysis of feeding induced by Delta9-THC and anandamide

21 January 2018

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Reversal of delta 9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine

21 January 2018

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Hyperphagia in pre-fed rats following oral delta9-THC.

21 January 2018

1 reference

Cannabinoids in clinical practice

21 January 2018

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Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

21 January 2018

1 reference

Cannabis use in HIV for pain and other medical symptoms

21 January 2018

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Tetrahydrocannabinolic Acid, a Genuine Substance of Tetrahydrocannabinol

21 January 2018

1 reference

Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity

21 January 2018

1 reference

Inactivation and biotransformation of the endogenous cannabinoids anandamide and 2-arachidonoylglycerol

21 January 2018

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Endocannabinoids selectively enhance sweet taste

21 January 2018

1 reference

Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana

21 January 2018

1 reference

Preliminary Experiments on the Chemistry and Pharmacology of Cannabis

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PTR.3375

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23 August 2017

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