(Q37831588)

24 August 2017

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title

Mechanisms of epileptogenesis and potential treatment targets (English)

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24 August 2017

1

Asla Pitkänen

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24 August 2017

Katarzyna Lukasiuk

2

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24 August 2017

publication date

1 February 2011

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24 August 2017

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24 August 2017

volume

10

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24 August 2017

issue

2

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24 August 2017

page(s)

173-186

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A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology

24 August 2017

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cDNA profiling of epileptogenesis in the rat brain

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Altered expression of novel genes in the cerebral cortex following experimental brain injury

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7 January 2021

Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy

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7 January 2021

The antiepileptic drug levetiracetam selectively modifies kindling-induced alterations in gene expression in the temporal lobe of rats

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7 January 2021

Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats

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7 January 2021

Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy.

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Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis

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7 January 2021

Complement activation in experimental and human temporal lobe epilepsy.

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7 January 2021

Cloning of expressed sequence tags (ESTs) representing putative epileptogenesis-related genes and the localization of their expression in the normal brain.

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7 January 2021

Expression of Ttyh1, a member of the Tweety family in neurons in vitro and in vivo and its potential role in brain pathology.

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7 January 2021

Cystatin C, a cysteine protease inhibitor, is persistently up-regulated in neurons and glia in a rat model for mesial temporal lobe epilepsy

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7 January 2021

Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis.

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7 January 2021

Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus

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7 January 2021

Induction of sodium channel Nax (SCN7A) expression in rat and human hippocampus in temporal lobe epilepsy

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7 January 2021

Dynamic changes of proteases and protease inhibitors revealed by microarray analysis in CA3 and entorhinal cortex during epileptogenesis in the rat

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7 January 2021

Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse.

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7 January 2021

Characterization of osteopontin expression and function after status epilepticus

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7 January 2021

Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

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7 January 2021

Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy

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7 January 2021

Increased expression of ferritin, an iron-storage protein, in specific regions of the parahippocampal cortex of epileptic rats.

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7 January 2021

Brain-derived neurotrophic factor and epilepsy--a missing link?

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7 January 2021

Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model

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7 January 2021

Therapeutic potential of erythropoietin and its structural or functional variants in the nervous system

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7 January 2021

Erythropoietin reduces epileptogenic processes following status epilepticus

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7 January 2021

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

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7 January 2021

Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice

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7 January 2021

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7 January 2021

The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy

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7 January 2021

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

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7 January 2021

Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus.

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7 January 2021

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

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7 January 2021

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

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7 January 2021

Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER).

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7 January 2021

Early treatment suppresses the development of spike-wave epilepsy in a rat model

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7 January 2021

Atipamezole, an alpha(2)-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats

1 reference

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7 January 2021

Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model

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7 January 2021

The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures.

1 reference

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7 January 2021

Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures

1 reference

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7 January 2021

Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy

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7 January 2021

Calcineurin inhibitors and rapamycin: cancer protection or promotion?

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7 January 2021

Inducible cAMP early repressor acts as a negative regulator for kindling epileptogenesis and long-term fear memory.

1 reference

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7 January 2021

The role of transcription factors cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER) in epileptogenesis

1 reference

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7 January 2021

Traumatic brain injury induces relocalization of DNA-methyltransferase 1.

1 reference

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7 January 2021

Global hypomethylation defines a sub-population of reactive microglia/macrophages in experimental traumatic brain injury

1 reference

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7 January 2021

Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Immunohistochemical analysis of histone H3 acetylation and methylation--evidence for altered epigenetic signaling following traumatic brain injury in immature rats

1 reference

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7 January 2021

HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats

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7 January 2021

Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injury

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7 January 2021

Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury

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7 January 2021

Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats

1 reference

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7 January 2021

Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Histone modifications in kainate-induced status epilepticus.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Loss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone development

1 reference

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7 January 2021

Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons

1 reference

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7 January 2021

Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection

1 reference

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7 January 2021

Epigenetic modulation of seizure-induced neurogenesis and cognitive decline.

1 reference

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7 January 2021

Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Effects of phenobarbital on DNA methylation in GC-rich regions of hepatic DNA from mice that exhibit different levels of susceptibility to liver tumorigenesis

1 reference

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7 January 2021

Rapamycin: brain excitability studied in vitro.

1 reference

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7 January 2021

Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons

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7 January 2021

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

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7 January 2021

Mechanism-based approaches to treating fragile X

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7 January 2021

Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy.

1 reference

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7 January 2021

Different electrophysiological actions of 24- and 72-hour aggregated amyloid-beta oligomers on hippocampal field population spike in both anesthetized and awake rats.

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7 January 2021

Alzheimer's secretases regulate voltage-gated sodium channels

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https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Correction of fragile X syndrome in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Limbic epileptogenesis in a mouse model of fragile X syndrome

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https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Axon initial segment dysfunction in epilepsy

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https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders

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7 January 2021

Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials

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7 January 2021

Antiepileptic drugs in neuroprotection

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7 January 2021

Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat.

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7 January 2021

Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system

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7 January 2021

Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Epileptogenesis in experimental models.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970310-0

7 January 2021

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials

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7 January 2021

Lost in translation: treatment trials in the SOD1 mouse and in human ALS.

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7 January 2021

10.1016/S1474-4422(10)70310-0

Identifiers

DOI

1 reference

24 August 2017

1 reference