(Q37834510)

24 August 2017

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title

Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition (English)

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24 August 2017

Pedro Cano-Soldado

1

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24 August 2017

Marçal Pastor-Anglada

series ordinal

2

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24 August 2017

publication date

1 February 2011

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Medicinal Research Reviews

24 August 2017

published in

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24 August 2017

volume

32

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24 August 2017

issue

2

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24 August 2017

page(s)

428-457

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The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology

24 August 2017

cites work

1 reference

H+-peptide cotransport in the human bile duct epithelium cell line SK-ChA-1.

21 January 2018

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Tubular localization and tissue distribution of peptide transporters in rat kidney

21 January 2018

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Distribution of peptide transporter PEPT2 mRNA in the rat nervous system

21 January 2018

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Peptide transport in the mammary gland: expression and distribution of PEPT2 mRNA and protein

21 January 2018

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Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake

21 January 2018

1 reference

From bacteria to man: archaic proton-dependent peptide transporters at work

21 January 2018

1 reference

Functional analysis of a chimeric mammalian peptide transporter derived from the intestinal and renal isoforms

21 January 2018

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Identification of a potential substrate binding domain in the mammalian peptide transporters PEPT1 and PEPT2 using PEPT1-PEPT2 and PEPT2-PEPT1 chimeras

21 January 2018

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Transmembrane segment 5 of the dipeptide transporter hPepT1 forms a part of the substrate translocation pathway

21 January 2018

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Analysis of Transmembrane Segment 7 of the Dipeptide Transporter hPepT1 by Cysteine-scanning Mutagenesis

21 January 2018

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Cysteine scanning of transmembrane domain three of the human dipeptide transporter: implications for substrate transport

21 January 2018

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Structure, function, and molecular modeling approaches to the study of the intestinal dipeptide transporter PepT1.

21 January 2018

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A charge pair interaction between Arg282 in transmembrane segment 7 and Asp341 in transmembrane segment 8 of hPepT1.

21 January 2018

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Site-directed mutation of arginine 282 to glutamate uncouples the movement of peptides and protons by the rabbit proton-peptide cotransporter PepT1.

21 January 2018

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Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1).

21 January 2018

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Functional roles of histidine and tyrosine residues in the H(+)-peptide transporter PepT1.

21 January 2018

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Identification of the histidyl residue obligatory for the catalytic activity of the human H+/peptide cotransporters PEPT1 and PEPT2.

21 January 2018

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Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function

21 January 2018

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Synthesis and characterization of high affinity inhibitors of the H+/peptide transporter PEPT2.

21 January 2018

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Differential recognition of ACE inhibitors in Xenopus laevis oocytes expressing rat PEPT1 and PEPT2.

21 January 2018

1 reference

A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 1: system characterisation.

21 January 2018

1 reference

Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.

21 January 2018

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Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2.

21 January 2018

1 reference

Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs

21 January 2018

1 reference

Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolism

21 January 2018

1 reference

Amino acid ester prodrugs of the anticancer agent gemcitabine: synthesis, bioconversion, metabolic bioevasion, and hPEPT1-mediated transport

21 January 2018

1 reference

Transport of levovirin prodrugs in the human intestinal Caco-2 cell line

21 January 2018

1 reference

5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter

21 January 2018

1 reference

Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives

21 January 2018

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Effects of glibenclamide on glycylsarcosine transport by the rat peptide transporters PEPT1 and PEPT2.

21 January 2018

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Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2.

21 January 2018

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The molecular pharmacology of organic anion transporters: from DNA to FDA?

21 January 2018

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Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles

21 January 2018

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Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family

21 January 2018

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Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors.

21 January 2018

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Role of human organic anion transporter 4 in the transport of ochratoxin A.

21 January 2018

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Expression of human organic anion transporters in the choroid plexus and their interactions with neurotransmitter metabolites

21 January 2018

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Isolation of a family of organic anion transporters from human liver and kidney

21 January 2018

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Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

21 January 2018

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The SLC22 drug transporter family

21 January 2018

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Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1.

21 January 2018

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Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition

21 January 2018

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A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport

21 January 2018

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The chloride dependence of the human organic anion transporter 1 (hOAT1) is blunted by mutation of a single amino acid

21 January 2018

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Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3.

21 January 2018

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Transport of organic anions across the basolateral membrane of proximal tubule cells

21 January 2018

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Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination

21 January 2018

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Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney

21 January 2018

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Interaction of human organic anion transporters with various cephalosporin antibiotics

21 January 2018

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Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics.

21 January 2018

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Human organic anion transporters mediate the transport of tetracycline

21 January 2018

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Human organic anion transporters and human organic cation transporters mediate renal antiviral transport

21 January 2018

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Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6).

21 January 2018

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Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2).

21 January 2018

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Characterization of methotrexate transport and its drug interactions with human organic anion transporters

21 January 2018

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Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]).

21 January 2018

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Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs

21 January 2018

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Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides

21 January 2018

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Organic cation transporters

21 January 2018

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Molecular and functional characterization of organic cation/carnitine transporter family in mice

21 January 2018

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Cloning and characterization of two human polyspecific organic cation transporters

21 January 2018

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Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium

21 January 2018

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Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).

21 January 2018

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Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27

21 January 2018

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Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter

21 January 2018

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Membrane localization of the electrogenic cation transporter rOCT1 in rat liver

21 January 2018

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Functional analysis of organic cation transporter 3 expressed in human placenta

21 January 2018

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Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus

21 January 2018

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cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney

21 January 2018

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Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease

21 January 2018

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Subtype-specific affinity for corticosterone of rat organic cation transporters rOCT1 and rOCT2 depends on three amino acids within the substrate binding region

21 January 2018

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Cysteine accessibility in the hydrophilic cleft of human organic cation transporter 2.

21 January 2018

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A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2).

21 January 2018

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High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices

21 January 2018

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Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2).

21 January 2018

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Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.

21 January 2018

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

21 January 2018

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Enantioselective binding to the human organic cation transporter-1 (hOCT1) determined using an immobilized hOCT1 liquid chromatographic stationary phase.

21 January 2018

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Pharmacophore modelling of stereoselective binding to the human organic cation transporter (hOCT1).

21 January 2018

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Development and characterization of an immobilized human organic cation transporter based liquid chromatographic stationary phase.

21 January 2018

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Molecular determinants of substrate/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2.

21 January 2018

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Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2).

21 January 2018

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Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.

21 January 2018

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Metformin transport by renal basolateral organic cation transporter hOCT2.

21 January 2018

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Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates

21 January 2018

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Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3

21 January 2018

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Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics

21 January 2018

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Role of organic cation transporters in the renal secretion of nucleosides

21 January 2018

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Organic cation transporters are determinants of oxaliplatin cytotoxicity.

21 January 2018

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Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2

21 January 2018

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Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications

21 January 2018

1 reference

The concentrative nucleoside transporter family, SLC28

21 January 2018

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Electrophysiological characterization of a recombinant human Na+-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes

21 January 2018

1 reference

Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3.

21 January 2018

1 reference

Electrophysiological characterization of the human Na(+)/nucleoside cotransporter 1 (hCNT1) and role of adenosine on hCNT1 function

21 January 2018

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The broadly selective human Na+/nucleoside cotransporter (hCNT3) exhibits novel cation-coupled nucleoside transport characteristics

21 January 2018

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A conformationally mobile cysteine residue (Cys-561) modulates Na+ and H+ activation of human CNT3

21 January 2018

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A proton-mediated conformational shift identifies a mobile pore-lining cysteine residue (Cys-561) in human concentrative nucleoside transporter 3.

21 January 2018

1 reference

Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells

21 January 2018

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Role of CNT3 in the transepithelial flux of nucleosides and nucleoside-derived drugs

21 January 2018

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Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies

21 January 2018

1 reference

Substituted cysteine accessibility method analysis of human concentrative nucleoside transporter hCNT3 reveals a novel discontinuous region of functional importance within the CNT family motif (G/A)XKX3NEFVA(Y/M/F).

21 January 2018

1 reference

Subcellular distribution and membrane topology of the mammalian concentrative Na+-nucleoside cotransporter rCNT1.

21 January 2018

1 reference

A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum.

21 January 2018

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Sorting of rat SPNT in renal epithelium is independent of N-glycosylation

21 January 2018

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Molecular determinants of substrate selectivity in Na+-dependent nucleoside transporters

21 January 2018

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Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2

21 January 2018

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Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling

21 January 2018

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Functional characterization of a nucleoside-derived drug transporter variant (hCNT3C602R) showing altered sodium-binding capacity.

21 January 2018

1 reference

Conserved glutamate residues Glu-343 and Glu-519 provide mechanistic insights into cation/nucleoside cotransport by human concentrative nucleoside transporter hCNT3

21 January 2018

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Conserved glutamate residues are critically involved in Na+/nucleoside cotransport by human concentrative nucleoside transporter 1 (hCNT1).

21 January 2018

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Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line

21 January 2018

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Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae

21 January 2018

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Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1.

21 January 2018

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Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3).

21 January 2018

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Electrogenic uptake of nucleosides and nucleoside-derived drugs by the human nucleoside transporter 1 (hCNT1) expressed in Xenopus laevis oocytes.

21 January 2018

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Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine

21 January 2018

1 reference

Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters

21 January 2018

1 reference

Intestinal absorption of ribavirin is preferentially mediated by the Na+-nucleoside purine (N1) transporter

21 January 2018

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Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines

21 January 2018

1 reference

Hypoxanthine enters human vascular endothelial cells (ECV 304) via the nitrobenzylthioinosine-insensitive equilibrative nucleoside transporter

21 January 2018

1 reference

Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes

21 January 2018

1 reference

The equilibrative nucleoside transporter family, SLC29

21 January 2018

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Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3.

21 January 2018

1 reference

Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs

21 January 2018

1 reference

Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH.

21 January 2018

1 reference

Identification and characterization of a novel monoamine transporter in the human brain

21 January 2018

1 reference

Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta

21 January 2018

1 reference

Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs

21 January 2018

1 reference

Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2

21 January 2018

1 reference

Equilibrative nucleoside transporters: mapping regions of interaction for the substrate analogue nitrobenzylthioinosine (NBMPR) using rat chimeric proteins

21 January 2018

1 reference

Chimeric constructs between human and rat equilibrative nucleoside transporters (hENT1 and rENT1) reveal hENT1 structural domains interacting with coronary vasoactive drugs

21 January 2018

1 reference

Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation

21 January 2018

1 reference

Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes

21 January 2018

1 reference

Residue 33 of human equilibrative nucleoside transporter 2 is a functionally important component of both the dipyridamole and nucleoside binding sites

21 January 2018

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Mutation of residue 33 of human equilibrative nucleoside transporters 1 and 2 alters sensitivity to inhibition of transport by dilazep and dipyridamole

21 January 2018

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Residues Met89 and Ser160 in the human equilibrative nucleoside transporter 1 affect its affinity for adenosine, guanosine, S6-(4-nitrobenzyl)-mercaptopurine riboside, and dipyridamole

21 January 2018

1 reference

A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine

21 January 2018

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Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1

21 January 2018

1 reference

Identification and mutational analysis of amino acid residues involved in dipyridamole interactions with human and Caenorhabditis elegans equilibrative nucleoside transporters

21 January 2018

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Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.

21 January 2018

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Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine

21 January 2018

1 reference

Differential regulation of mouse equilibrative nucleoside transporter 1 (mENT1) splice variants by protein kinase CK2.

21 January 2018

1 reference

Cloning of a novel isoform of the mouse NBMPR-sensitive equilibrative nucleoside transporter (ENT1) lacking a putative phosphorylation site

21 January 2018

1 reference

Characterization of mENT1Delta11, a novel alternative splice variant of the mouse equilibrative nucleoside transporter 1.

21 January 2018

1 reference

Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line

21 January 2018

1 reference

Fine tuning of rabbit equilibrative nucleoside transporter activity by an alternatively spliced variant

21 January 2018

1 reference

Uridine recognition motifs of human equilibrative nucleoside transporters 1 and 2 produced in Saccharomyces cerevisiae

21 January 2018

1 reference

Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. Ent2 exhibits a low affinity for guanosine and cytidine but a high affinity

21 January 2018

1 reference

Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine-sensitive (es)-nucleoside transporters

21 January 2018

1 reference

Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters

21 January 2018

1 reference

Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia

21 January 2018

1 reference

Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5'-DFUR in breast cancer MCF7 cells.

21 January 2018

1 reference

Nucleoside analogues: mechanisms of drug resistance and reversal strategies.

21 January 2018

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In vivo mechanisms of resistance to cytarabine in acute myeloid leukaemia.

21 January 2018

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The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs

21 January 2018

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Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma

21 January 2018

1 reference

Quantitative analysis of nucleoside transporter and metabolism gene expression in chronic lymphocytic leukemia (CLL): identification of fludarabine-sensitive and -insensitive populations

21 January 2018

1 reference

Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer.

21 January 2018

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The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma.

21 January 2018

1 reference

Human equilibrative nucleoside transporter 1 (hENT1) protein is associated with short survival in resected ampullary cancer

21 January 2018

1 reference

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

21 January 2018

1 reference

Structure of a glutamate transporter homologue from Pyrococcus horikoshii

21 January 2018

1 reference

Unlocking the molecular secrets of sodium-coupled transporters.

21 January 2018

1 reference

Biophysical evidence for His57 as a proton-binding site in the mammalian intestinal transporter hPepT1.

21 January 2018

1 reference

Renal transporters for organic anions and organic cations. Structural requirements for substrates

21 January 2018

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Interactions of human organic anion transporters with diuretics.

21 January 2018

1 reference

Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2

21 January 2018

1 reference

Relevance of the organic cation transporters 1 and 2 for antiretroviral drug therapy in human immunodeficiency virus infection

21 January 2018

1 reference

Cysteine-accessibility analysis of transmembrane domains 11-13 of human concentrative nucleoside transporter 3.

21 January 2018

1 reference

Functional production and reconstitution of the human equilibrative nucleoside transporter (hENT1) in Saccharomyces cerevisiae. Interaction of inhibitors of nucleoside transport with recombinant hENT1 and a glycosylation-defective derivative (hENT1/

21 January 2018

1 reference

Analysis of the transport properties of side chain modified dipeptides at the mammalian peptide transporter PEPT1.

21 January 2018

1 reference

A novel inhibitor of the mammalian peptide transporter PEPT1.

21 January 2018

1 reference

Pharmaceutical and pharmacological importance of peptide transporters

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.20221

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24 August 2017

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